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1.发明授权公开(公告)号：US06803205B2
公开(公告)日：2004-10-12
申请号：US10206534
申请日：2002-07-29
IPC分类号： C12Q148
CPC分类号： G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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2.发明授权Methods for processing biological materials using peelable and resealable devices 失效使用可剥离和可重新密封的装置处理生物材料的方法公开(公告)号：US07351575B2
公开(公告)日：2008-04-01
申请号：US10206590
申请日：2002-07-29
CPC分类号： G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12M23/34 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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3.发明授权Methods of arraying biological materials using peelable and resealable devices 失效使用可剥离和可再密封装置排列生物材料的方法公开(公告)号：US07001740B2
公开(公告)日：2006-02-21
申请号：US10206075
申请日：2002-07-29
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G06T7/0012 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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公开(公告)号：US06967074B2
公开(公告)日：2005-11-22
申请号：US10206081
申请日：2002-07-29
CPC分类号： G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates thc performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦的表面，其有利于在和/或 检测固定化材料。
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5.发明申请METHODS OF ARRAYING BIOLOGICAL MATERIALS USING PEELABLE AND RESEALABLE DEVICES 失效使用可剥离和可擦除装置对生物材料进行排列的方法公开(公告)号：US20050250097A1
公开(公告)日：2005-11-10
申请号：US10206075
申请日：2002-07-29
IPC分类号： B01L3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/543 , G01Q60/00 , G06T7/00 , C12Q1/68 , C12M1/34 , C12Q1/48
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/54366 , G06T7/0012 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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公开(公告)号：US20050100974A1
公开(公告)日：2005-05-12
申请号：US10206081
申请日：2002-07-29
IPC分类号： B01L3/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/543 , G01Q60/00 , G06T7/00 , G01N33/53 , C12Q1/37 , G01N33/537
CPC分类号： G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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公开(公告)号：US07439056B2
公开(公告)日：2008-10-21
申请号：US10206080
申请日：2002-07-29
申请人： David Duffy , Gregory Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto , Enoch Kim
发明人： David Duffy , Gregory Kirk , Stewart Campbell , Olivier Schueller , Melina Agosto , Enoch Kim
CPC分类号： G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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公开(公告)号：US07371563B2
公开(公告)日：2008-05-13
申请号：US10206074
申请日：2002-07-29
申请人： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Amber Agosto , Enoch Kim
发明人： David Duffy , Gregory L. Kirk , Stewart Campbell , Olivier Schueller , Melina Amber Agosto , Enoch Kim
CPC分类号： G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/30072 , Y10T428/24281 , Y10T428/24289 , Y10T428/24306
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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9.发明申请公开(公告)号：US20090325262A1
公开(公告)日：2009-12-31
申请号：US12081650
申请日：2008-04-18
CPC分类号： B82Y30/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00686 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00727 , B82Y40/00 , C07B2200/11 , C07K1/1077 , C12N9/18 , C12N11/14 , C40B40/00 , G01N33/54353
摘要： The present invention provides an article for immobilizing functional organic biomolecules through a covalent bond to a thiolate monolayer on a coinage metal surface. Also provided are methods for making the article and method for the immobilization of functional organic biomolecules on the article. The thiolate monolayer contains two moieties, one having an inert group that is resistant to reacting with biomolecules and one having a covalent bond forming group that reacts with the functional organic biomolecule to covalently immobilize it on the monolayer.
摘要翻译： 本发明提供了通过共价键将功能性有机生物分子固定在造币金属表面上的硫醇盐单层的制品。 还提供了制备用于将功能性有机生物分子固定在制品上的制品和方法的方法。 硫醇盐单层包含两个部分，一个具有与生物分子反应的惰性基团，一个具有共价键形成基团的官能团与功能性有机生物分子反应以将其共价固定在单层上。
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10.发明申请Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds 审中-公开制备包含功能性残基或组的药代动力学改进的化合物的方法以及包含所述化合物的药物组合物公开(公告)号：US20110172422A1
公开(公告)日：2011-07-14
申请号：US11884811
申请日：2006-02-21
申请人： Stewart Campbell , David Duffy , Michael Grogan , Steven Kates , Emanuele Ostuni , Olivier Schueller , Paul Sweetnam
发明人： Stewart Campbell , David Duffy , Michael Grogan , Steven Kates , Emanuele Ostuni , Olivier Schueller , Paul Sweetnam
IPC分类号： C07D487/04
CPC分类号： A61K31/53
摘要： The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds.
摘要翻译： 本发明涉及通过将至少一个功能单元或基团连接到化合物上来调节化合物的药代动力学和/或药效学性质的方法，从而改善其非特异性结合特征和/或药代动力学性质。 提供包含至少一个功能性残基的化合物，以及包含所述化合物的药物组合物。
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