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25 条记录 (耗时 0.029 秒)

    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
    1.
    发明授权
    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof 失效
    能够进行糖基化，生产和使用的单链抗原结合蛋白

    公开(公告)号：US06323322B1

    公开(公告)日：2001-11-27

    申请号：US09069821

    申请日：1998-04-30

    申请人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    发明人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    IPC分类号： C07K1600

    CPC分类号： G01N33/6857 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/30 ,  C07K19/00 ,  C07K2317/41 ,  C07K2317/622 ,  C07K2319/00

    摘要： The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Composition of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.

    摘要翻译： 本发明涉及能够进行糖基化的单链抗原结合分子。 描述和要求保护编码的组成，以及产生能够糖基化的单价和多价单链抗原结合分子的方法。 描述和要求保护编码的遗传结构的组成，以及能够产生聚环氧烷共轭的糖基化单价和多价单链抗原结合分子的方法。 本发明还涉及生产具有增加的糖基化的多肽的方法和通过所述方法产生的多肽。 还描述和要求保护由糖基化/聚环氧烷结合的抗原结合蛋白的多功能性产生的用途。

    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
    3.
    发明授权
    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof 有权
    能够进行糖基化，生产和使用的单链抗原结合蛋白

    公开(公告)号：US06743908B2

    公开(公告)日：2004-06-01

    申请号：US09956087

    申请日：2001-09-20

    申请人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    发明人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    IPC分类号： C07H2104

    CPC分类号： G01N33/6857 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/30 ,  C07K19/00 ,  C07K2317/41 ,  C07K2317/622 ,  C07K2319/00

    摘要： The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Composition of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.

    摘要翻译： 本发明涉及能够进行糖基化的单链抗原结合分子。 描述和要求保护编码的组成，以及产生能够糖基化的单价和多价单链抗原结合分子的方法。 描述和要求保护编码的遗传结构的组成，以及能够产生聚环氧烷共轭的糖基化单价和多价单链抗原结合分子的方法。 本发明还涉及生产具有增加的糖基化的多肽的方法和通过所述方法产生的多肽。 还描述和要求保护由糖基化/聚环氧烷结合的抗原结合蛋白的多功能性产生的用途。

    Electrophoretic media
    10.
    发明授权
    Electrophoretic media 失效
    电泳媒体

    公开(公告)号：US5219923A

    公开(公告)日：1993-06-15

    申请号：US568237

    申请日：1990-08-15

    申请人： Robert Shorr

    发明人： Robert Shorr

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44747 ,  Y10S524/916

    摘要： Electrophoretic media based on polymers with novel structures are disclosed. The polymers are formed by polymerization of acrylamide monomers, such as N-methylolacrylamide, with cross-linking agents or comonomer agents such as tetraethylene diacrylate and bisacrylamide methylether.

    摘要翻译： 公开了基于具有新颖结构的聚合物的电泳介质。 聚合物通过丙烯酰胺单体如N-羟甲基丙烯酰胺与交联剂或共聚单体剂例如四亚乙基二丙烯酸酯和双丙烯酰胺甲基醚的聚合形成。