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19 条记录 (耗时 0.023 秒)

    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
    4.
    发明授权
    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof 失效
    能够进行糖基化，生产和使用的单链抗原结合蛋白

    公开(公告)号：US06323322B1

    公开(公告)日：2001-11-27

    申请号：US09069821

    申请日：1998-04-30

    申请人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    发明人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    IPC分类号： C07K1600

    CPC分类号： G01N33/6857 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/30 ,  C07K19/00 ,  C07K2317/41 ,  C07K2317/622 ,  C07K2319/00

    摘要： The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Composition of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.

    摘要翻译： 本发明涉及能够进行糖基化的单链抗原结合分子。 描述和要求保护编码的组成，以及产生能够糖基化的单价和多价单链抗原结合分子的方法。 描述和要求保护编码的遗传结构的组成，以及能够产生聚环氧烷共轭的糖基化单价和多价单链抗原结合分子的方法。 本发明还涉及生产具有增加的糖基化的多肽的方法和通过所述方法产生的多肽。 还描述和要求保护由糖基化/聚环氧烷结合的抗原结合蛋白的多功能性产生的用途。

    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
    6.
    发明授权
    Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof 有权
    能够进行糖基化，生产和使用的单链抗原结合蛋白

    公开(公告)号：US06743908B2

    公开(公告)日：2004-06-01

    申请号：US09956087

    申请日：2001-09-20

    申请人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    发明人： David Filpula ,  Maoliang Wang ,  Robert Shorr ,  Marc Whitlow ,  Lihsyng S. Lee

    IPC分类号： C07H2104

    CPC分类号： G01N33/6857 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/30 ,  C07K19/00 ,  C07K2317/41 ,  C07K2317/622 ,  C07K2319/00

    摘要： The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Composition of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.

    摘要翻译： 本发明涉及能够进行糖基化的单链抗原结合分子。 描述和要求保护编码的组成，以及产生能够糖基化的单价和多价单链抗原结合分子的方法。 描述和要求保护编码的遗传结构的组成，以及能够产生聚环氧烷共轭的糖基化单价和多价单链抗原结合分子的方法。 本发明还涉及生产具有增加的糖基化的多肽的方法和通过所述方法产生的多肽。 还描述和要求保护由糖基化/聚环氧烷结合的抗原结合蛋白的多功能性产生的用途。

    Methods for producing multivalent antigen-binding proteins
    9.
    发明授权
    Methods for producing multivalent antigen-binding proteins 失效
    产生多价抗原结合蛋白的方法

    公开(公告)号：US6025165A

    公开(公告)日：2000-02-15

    申请号：US166750

    申请日：1998-10-05

    申请人： Marc D. Whitlow ,  James F. Wood ,  Karl D. Hardman ,  Robert E. Bird ,  David Filpula ,  Michele Rollence

    发明人： Marc D. Whitlow ,  James F. Wood ,  Karl D. Hardman ,  Robert E. Bird ,  David Filpula ,  Michele Rollence

    IPC分类号： A61P37/04 ,  C07K1/22 ,  C07K16/30 ,  C07K16/44 ,  C07K16/46 ,  C12P21/08 ,  A61K39/395 ,  C07H21/04 ,  C07K16/00

    CPC分类号： C07K1/22 ,  C07K16/30 ,  C07K16/44 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2319/00

    摘要： Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single-chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.

    摘要翻译： 描述和要求保护编码的遗传结构的组合物和用于产生多价抗原结合蛋白的方法。 所述方法包括纯化含有单一和多价形式的单一多肽链分子的组合物，以及从纯化单体产生多价蛋白质。 多价蛋白质的产生可以通过单体蛋白质的浓度依赖性缔合，或通过重新排列涉及解离的区域，然后重新结合不同的区域来进行。 在本发明中制备了包含同型和异二价蛋白质的二价蛋白质。 公开了编码二价单链抗原结合蛋白的遗传序列。 用途包括适用于单克隆和多克隆抗体及其片段的所有应用，包括用作双特异性抗原结合分子。