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公开(公告)号：US08207344B2
公开(公告)日：2012-06-26
申请号：US12834054
申请日：2010-07-12
申请人： David Gene Barrett , Ana Belen Bueno Melendo , Jeffry Bernard Franciskovich , Bin Liu , Kumiko Takeuchi
发明人： David Gene Barrett , Ana Belen Bueno Melendo , Jeffry Bernard Franciskovich , Bin Liu , Kumiko Takeuchi
IPC分类号： C07D401/00 , C07D211/08 , A61K31/445
CPC分类号： C07D401/12 , C07D401/14
摘要： GPR119 agonist compounds of the formula: and pharmaceutical compositions for the treatment of diabetes and obesity.
摘要翻译： GPR119激动剂化合物，以及用于治疗糖尿病和肥胖症的药物组合物。
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公开(公告)号：US20110015199A1
公开(公告)日：2011-01-20
申请号：US12834054
申请日：2010-07-12
申请人： David Gene Barrett , Ana Belen Bueno Melendo , Jeffry Bernard Franciskovich , Bin Liu , Kumiko Takeuchi
发明人： David Gene Barrett , Ana Belen Bueno Melendo , Jeffry Bernard Franciskovich , Bin Liu , Kumiko Takeuchi
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , A61K31/4985 , A61P3/04 , A61P3/10
CPC分类号： C07D401/12 , C07D401/14
摘要： GPR119 agonist compounds of the formula: and pharmaceutical compositions for the treatment of diabetes and obesity.
摘要翻译： GPR119激动剂化合物，以及用于治疗糖尿病和肥胖症的药物组合物。
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公开(公告)号：US08063079B2
公开(公告)日：2011-11-22
申请号：US12635758
申请日：2009-12-11
IPC分类号： A61K31/427 , C07D417/12 , A61P3/10
CPC分类号： C07D277/46
摘要： A compound of the formula: and pharmaceutical compositions for the treatment of diabetes.
摘要翻译： 一种下式的化合物：用于治疗糖尿病的药物组合物。
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公开(公告)号：US20100160395A1
公开(公告)日：2010-06-24
申请号：US12635758
申请日：2009-12-11
IPC分类号： A61K31/427 , C07D417/12 , A61P3/10
CPC分类号： C07D277/46
摘要： A compound of the formula: and pharmaceutical compositions for the treatment of diabetes.
摘要翻译： 一种下式的化合物：用于治疗糖尿病的药物组合物。
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公开(公告)号：US08153624B2
公开(公告)日：2012-04-10
申请号：US12600879
申请日：2008-07-11
申请人： Michael James Genin , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Alan M. Warshawsky
发明人： Michael James Genin , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Alan M. Warshawsky
IPC分类号： A61K31/55 , C07D405/00
CPC分类号： C07D261/08 , C07D413/12
摘要： Compounds of formula (I): formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and diseases related to dyslipidemia.
摘要翻译： 公开了式（I）化合物：其中变量如本文所定义的式（I）及其药物组合物和使用方法用于治疗血脂异常和与血脂异常有关的疾病。
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公开(公告)号：US20080306125A1
公开(公告)日：2008-12-11
申请号：US12159224
申请日：2007-02-02
申请人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
发明人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
IPC分类号： A61K31/4245 , C07D261/06 , A61K31/422 , C07D275/04 , A61K31/428 , A61P3/10 , A61P9/10 , C07D277/20 , A61K31/426 , C07D271/10
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 式的化合物。 其中变量如本文所定义，并且其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。
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公开(公告)号：US07038077B2
公开(公告)日：2006-05-02
申请号：US10465972
申请日：2002-01-09
申请人： Anne Hollins Dantzig , James Allen Monn , Stephanie Ann Sweetana , Ana Belen Bueno Melendo , Alfonso De Dios , Carmen Dominguez-Fernandez , Marc Francis Herin , Luisa Maria Martin-Cabrejas , Jose Alfredo Martin , Maria Angeles Martinez-Grau , Carlos Montero Salgado , Concepcion Pedregal-Tercero
发明人： Anne Hollins Dantzig , James Allen Monn , Stephanie Ann Sweetana , Ana Belen Bueno Melendo , Alfonso De Dios , Carmen Dominguez-Fernandez , Marc Francis Herin , Luisa Maria Martin-Cabrejas , Jose Alfredo Martin , Maria Angeles Martinez-Grau , Carlos Montero Salgado , Concepcion Pedregal-Tercero
IPC分类号： C07C61/12
CPC分类号： C07C237/22 , A61K31/195 , A61K38/00 , A61K39/00 , C07C237/14 , C07C237/20 , C07C271/22 , C07C2602/18 , C07D207/16 , C07D209/18 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06113 , C07K5/06191 , C07K5/0806 , C07K5/0808 , C07K5/1008
摘要： This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.
摘要翻译： 本发明涉及合成兴奋性氨基酸前药及其制备方法。 本发明进一步涉及使用和药物组合物的方法，其包含用于治疗神经障碍和精神障碍的化合物。
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公开(公告)号：US06498180B1
公开(公告)日：2002-12-24
申请号：US09979322
申请日：2001-11-16
申请人： Ivan Collado Cano , Concepcion Pedregal Tercero , Alicia Marcos Llorente , Beatriz Lopez de Uralde Garmendia , Maria Rosario Gonzalez Garcia , Ana Belen Bueno Melendo
发明人： Ivan Collado Cano , Concepcion Pedregal Tercero , Alicia Marcos Llorente , Beatriz Lopez de Uralde Garmendia , Maria Rosario Gonzalez Garcia , Ana Belen Bueno Melendo
IPC分类号： C01D31190
CPC分类号： C07C229/28 , C07B2200/07 , C07C2601/02
摘要： Compounds of formula (I) in which R1 is halo-C1-10 alkyl; halo-C2-10 alkenyl; or (CH2)nY in which n is 1 or 2 and Y is OH, CN, N3, OR3, SH, S(O)pR4, S(O)3H, NH2, NHR5, NR6R7, NHCOR8, NO2, CO2H, CONHR9, 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO3H2; R3, R5, R6, R7, R8 and R9 are each selected independently from C1-4 alkyl, aryl and aryl-C1-4 alkyl; R4 is selected from C1-4 alkyl, aryl, aryl-C1-4 alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C1-4 alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R1 is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.
摘要翻译： 其中R 1为卤代C 1-10烷基的式（I）化合物; 卤代-C2-10烯基; 或其中n为1或2且Y为OH，CN，N 3，OR 3，SH，S（O）p R 4，S（O）3 H，NH 2，NHR 5，NR 6 R 7，NHCOR 8，NO 2，CO 2 H，CONHR 9的（CH 2）n Y ，1H-四唑-5-基，5-苯基四唑-2-基或PO 3 H 2; R 3，R 5，R 6，R 7，R 8和R 9各自独立地选自C 1-4烷基，芳基和芳基-C 1-4烷基; R 4选自C 1-4烷基，芳基，芳基-C 1-4烷基和1H-四唑-5-基，羧基 - （1-4C）烷基和1H-四唑-5-基-C 1-4烷基; p为0,1,2或3; 或其盐或酯，条件是R1不是甲氧基甲基，调节代谢型谷氨酸受体功能，并且可用于治疗中枢神经系统的病症。
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公开(公告)号：US07863302B2
公开(公告)日：2011-01-04
申请号：US12159224
申请日：2007-02-02
申请人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
发明人： Michael Gregory Bell , Michael James Genin , Peter Ambrose Lander , Lindsay Scott Stelzer , Robert Anthony Doti , Francisco Javier Agejas-Chicharro , Ana Belen Bueno Melendo , Peter Rudolph Manninen , Jason Matthew Ochoada , Quanrong Shen , Alan M. Warshawsky , Tianwei Ma , Ryan Edward Stites
IPC分类号： A61K31/4245 , A61K31/422 , A61K31/428 , A61P3/10 , C07D261/06 , C07D275/04 , C07D277/20
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of formula and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.
摘要翻译： 公开的化合物及其药物组合物和使用方法可用于治疗血脂异常和相关疾病。
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10.发明授权3-(2-acylamino-1-hydroxyethyl)-morpholine derivatives and their use as bace inhibitors 有权3-（2-酰基氨基-1-羟乙基） - 吗啉衍生物及其作为抑制剂的用途公开(公告)号：US07745438B2
公开(公告)日：2010-06-29
申请号：US11574989
申请日：2005-09-20
申请人： Howard Barff Broughton , Robert Dean Dally , Timothy Barrett Durham , Maria Rosario Gonzalez-Garcia , Patric James Hahn , Kenneth James Henry, Jr. , Todd Jonathan Kohn , James Ray McCarthy , Timothy Alan Shepherd , Jon Andre Erickson , Ana Belen Bueno Melendo
发明人： Howard Barff Broughton , Robert Dean Dally , Timothy Barrett Durham , Maria Rosario Gonzalez-Garcia , Patric James Hahn , Kenneth James Henry, Jr. , Todd Jonathan Kohn , James Ray McCarthy , Timothy Alan Shepherd , Jon Andre Erickson , Ana Belen Bueno Melendo
IPC分类号： C07D265/32 , A61K31/5377
CPC分类号： C07C271/20 , C07C233/36 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D265/30 , C07D265/32 , C07D413/12 , C07F7/1804
摘要： The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.
摘要翻译： 本发明提供式（I）的BACE抑制剂; 使用和制备方法，以及可用于制备的中间体。
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