-
1.发明授权Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase 失效使用D-苏氨酸醛缩酶的2-氨基-3-羟基-3-苯基丙酸的立体异构富集
公开(公告)号：US5346828A
公开(公告)日：1994-09-13
申请号：US844724
申请日：1992-03-02
IPC分类号： C07C227/04 , C07C315/06 , C07C317/48 , C07C319/28 , C07C323/63 , C12P7/24 , C12P11/00 , C12P13/04 , C12P41/00
CPC分类号： C07C315/06 , C07C319/28 , C12P11/00 , C12P13/04 , C12P41/00 , C12P7/24 , C07B2200/07 , Y02P20/55 , Y10S435/829
摘要： Mixtures of enantiomeric D,L-threo 2-amino-3-hydroxy-3-phenylpropionic acids can be stereoisomerically enriched by contacting the mixture with a D-threonine aldolase. In a typical embodiment, D- and L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid is treated with D-threonine aldolase to produce L-threo 2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid with a high ee. The benzaldehyde and amino acid formed from the D-threo isomer can be recycled.
摘要翻译： 对映异构体D，L-苏氨酸2-氨基-3-羟基-3-苯基丙酸的混合物可以通过将该混合物与D-苏氨酸醛缩酶接触来进行立体异构富集。 在典型的实施方案中，用D-苏氨酸醛缩酶处理D-和L-苏氨酸2-氨基-3-羟基-3-（4-甲基磺酰基苯基）丙酸以产生L-苏氨酸2-氨基-3-羟基-3- （4-甲基磺酰基苯基）丙酸，高ee。 可以回收由D-苏糖异构体形成的苯甲醛和氨基酸。
-
2.发明申请METHODS FOR TREATMENT OF COGNITIVE AND MENOPAUSAL DISORDERS WITH D-THREO METHYLPHENIDATE 审中-公开用甲基苯甲酸D-THREO治疗认知障碍和男性疾病的方法公开(公告)号：US20130053414A1
公开(公告)日：2013-02-28
申请号：US13661472
申请日：2012-10-26
申请人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
发明人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
IPC分类号： A61K31/4458 , A61P25/00 , A61P25/24 , A61P3/00
CPC分类号： C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。
-
公开(公告)号：US5300437A
公开(公告)日：1994-04-05
申请号：US959147
申请日：1992-10-09
CPC分类号： C12N9/1096 , C12P41/006 , C12P7/26
摘要： Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
摘要翻译： 其中氨基在手性取代的仲碳原子上的胺可通过ω-氨基酸转氨酶的作用而被对映体富集，该氨基酸转氨酶具有优先将两种手性形式之一转化为酮的性质。 该方法还可以用于立体选择性地从酮中合成一种手性形式，基本上排除另一种。
-
4.发明申请Method Of Treating Attention Deficit Disorders With D-Threo Methylphenidate 审中-公开用D-Threo哌甲酯治疗注意力缺陷障碍的方法公开(公告)号：US20110201645A1
公开(公告)日：2011-08-18
申请号：US13093917
申请日：2011-04-26
IPC分类号： A61K31/4458 , A61P25/00
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
摘要翻译： 治疗注意力缺陷障碍，注意力缺陷多动障碍，艾滋病痴呆综合征和艾滋病毒/艾滋病认知衰退的方法，同时通过施用二硫代哌甲酯或药学上可接受的方式尽量减少药物过敏反应，毒性，副作用，欣欣乐效和药物滥用潜力 的盐。
-
公开(公告)号：US5169780A
公开(公告)日：1992-12-08
申请号：US549830
申请日：1990-07-09
CPC分类号： C12N9/1096 , C12P41/006 , C12P7/26
摘要： Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.
摘要翻译： 其中氨基在手性取代的仲碳原子上的胺可通过ω-氨基酸转氨酶的作用而被对映体富集，该氨基酸转氨酶具有优先将两种手性形式之一转化为酮的性质。 该方法可用于立体选择性地将酮的一种手性形式基本上与另一种不同。 与ω-氨基酸转氨酶和氨基受体接触后手性胺的水溶液用水不混溶的有机溶剂处理，水相和有机相被分离，水相可再循环以进一步接触 与转氨酶。
-
6.发明申请Methods For Treatment Of Cognitive And Menopausal Disorders With D-Threo Methylphenidate 审中-公开用D-Threo哌甲酯治疗认知障碍和绝经期疾病的方法公开(公告)号：US20100093797A1
公开(公告)日：2010-04-15
申请号：US12640734
申请日：2009-12-17
申请人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
发明人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
IPC分类号： A61K31/445 , A61P15/00 , A61P35/04
CPC分类号： C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。
-
7.发明授权Lactams and processes for stereoselective enrichment of lactams, amides, and esters 失效内酰胺和立体选择性富集内酰胺，酰胺和酯的方法
公开(公告)号：US5733756A
公开(公告)日：1998-03-31
申请号：US583317
申请日：1996-01-05
IPC分类号： C07D211/34 , C12P17/12 , C12P41/00 , C07D211/26
CPC分类号： C07D211/34 , C12P17/12 , C12P41/006
摘要： Novel lactams and processes for the preparation of chiral compounds having utility as intermediates in the synthesis of compounds with Central Nervous System stimulant activity.
摘要翻译： 新型内酰胺和制备手性化合物的方法，其具有在具有中枢神经系统兴奋剂活性的化合物的合成中作为中间体的作用。
-
公开(公告)号：US5908850A
公开(公告)日：1999-06-01
申请号：US827230
申请日：1997-04-02
IPC分类号： A61K31/4458 , A61K31/445
CPC分类号： A61K31/4458
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
-
公开(公告)号：US4950606A
公开(公告)日：1990-08-21
申请号：US369723
申请日：1989-06-22
IPC分类号： C07C209/00 , C12N9/10 , C12P7/26 , C12P41/00
CPC分类号： C12N9/1096 , C12P41/006 , C12P7/26
摘要： Amines in which the amino group is on a secondary carbon atom which is chrially substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
-
10.发明申请Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders 审中-公开使用免疫调节化合物治疗横纹肌肉炎，多发性硬化症和其他疾病公开(公告)号：US20090155207A1
公开(公告)日：2009-06-18
申请号：US12324728
申请日：2008-11-26
IPC分类号： A61K38/21 , A61K31/56 , A61K31/445 , A61K39/395
CPC分类号： A61K31/00 , A61K31/454 , A61K31/573 , A61K38/212 , A61K38/215 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing or managing transverse myelitis, multiple sclerosis, and/or other disorders are disclosed. The methods encompass the administration of an immunomodulatory compound provided herein, such as 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl-piperidine-2,6-dione or 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline. Further described are methods of treatment using the immunomodulatory compounds in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
摘要翻译： 公开了治疗，预防或治疗横贯性脊髓炎，多发性硬化症和/或其它病症的方法。 所述方法包括给予本文提供的免疫调节化合物，例如3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基 - 哌啶-2,6-二酮或1,3-二氧代 -2-（2,6-二氧代哌啶-3-基）-4-氨基异吲哚啉进一步描述了使用免疫调节化合物与第二活性剂组合的治疗方法。适用于该方法的药物组合物和单一单位剂型 还公开了本文。
-
-
-
-
-
-
-
-
-
搜索结果
49 条记录 (耗时 0.022 秒)
