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1.发明申请Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders 审中-公开使用免疫调节化合物治疗横纹肌肉炎，多发性硬化症和其他疾病公开(公告)号：US20090155207A1
公开(公告)日：2009-06-18
申请号：US12324728
申请日：2008-11-26
IPC分类号： A61K38/21 , A61K31/56 , A61K31/445 , A61K39/395
CPC分类号： A61K31/00 , A61K31/454 , A61K31/573 , A61K38/212 , A61K38/215 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing or managing transverse myelitis, multiple sclerosis, and/or other disorders are disclosed. The methods encompass the administration of an immunomodulatory compound provided herein, such as 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl-piperidine-2,6-dione or 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline. Further described are methods of treatment using the immunomodulatory compounds in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
摘要翻译： 公开了治疗，预防或治疗横贯性脊髓炎，多发性硬化症和/或其它病症的方法。 所述方法包括给予本文提供的免疫调节化合物，例如3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基 - 哌啶-2,6-二酮或1,3-二氧代 -2-（2,6-二氧代哌啶-3-基）-4-氨基异吲哚啉进一步描述了使用免疫调节化合物与第二活性剂组合的治疗方法。适用于该方法的药物组合物和单一单位剂型 还公开了本文。
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公开(公告)号：US08460650B2
公开(公告)日：2013-06-11
申请号：US12030161
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
IPC分类号： A01N65/00
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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3.发明申请TREATMENT OF RHEUMATOID ARTHRITIS USING PLACENTAL STEM CELLS 审中-公开使用PLACENTAL STEM细胞治疗RHEUMATOID ARTHRITIS公开(公告)号：US20110280845A1
公开(公告)日：2011-11-17
申请号：US13107727
申请日：2011-05-13
申请人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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公开(公告)号：US08753883B2
公开(公告)日：2014-06-17
申请号：US13107778
申请日：2011-05-13
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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公开(公告)号：US20110280843A1
公开(公告)日：2011-11-17
申请号：US13107778
申请日：2011-05-13
申请人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. EDINGER , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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6.发明申请TREATMENT OF DISEASES, DISORDERS OR CONDITIONS OF THE LUNG USING PLACENTAL CELLS 审中-公开治疗使用PLACENTAL细胞的肺部疾病，病症或病症公开(公告)号：US20100143312A1
公开(公告)日：2010-06-10
申请号：US12624359
申请日：2009-11-23
申请人： Robert J. HARIRI , Herbert Faleck , Andrew Zeitlin
发明人： Robert J. HARIRI , Herbert Faleck , Andrew Zeitlin
CPC分类号： C12N5/0605 , A61K35/50 , C12N5/0668
摘要： Provided herein are compositions and methods of treatment of individuals having a disease, disorder or condition of the lung, comprising administering a therapeutically-effective amount of placental cells, e.g., placental stem cells.
摘要翻译： 本文提供了治疗患有肺疾病，病症或状况的个体的组合物和方法，包括施用治疗有效量的胎盘细胞，例如胎盘干细胞。
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公开(公告)号：US20080226595A1
公开(公告)日：2008-09-18
申请号：US12030161
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Herbert Faleck
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译： 本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。
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公开(公告)号：US20130158073A1
公开(公告)日：2013-06-20
申请号：US13765994
申请日：2013-02-13
申请人： Vikram Khetani , Herbert Faleck
发明人： Vikram Khetani , Herbert Faleck
IPC分类号： A61K31/4458
CPC分类号： A61K31/4458
摘要： Methods of diminishing or eliminating the co-abuse of a methylphenidate drug comprising identifying a patient or patient group suspected or likely to abuse said methylphenidate drug in combination with a substance known or suspected to give rise to l-ethylphenidate or psychotropic effect when ingested in the combination and making available to said patent or patient group said methylphenidate drug substantially free of l-threo methylphenidate.
摘要翻译： 减少或消除哌甲酯药物的共同滥用的方法包括鉴定怀疑或可能滥用所述哌甲酯类药物的患者或患者组合与已知或怀疑产生1-乙酯或精神药效作用的物质组合， 组合并提供给所述专利或患者组，所述哌甲酯药物基本上不含1-苏式哌甲酯。
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9.发明申请Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain 审中-公开使用方法和包含选择性细胞因子抑制药物用于治疗，改变和治疗疼痛的组合物公开(公告)号：US20070161696A1
公开(公告)日：2007-07-12
申请号：US10576139
申请日：2004-04-23
申请人： Jerome Zeldis , Herbert Faleck , Donald Manning
发明人： Jerome Zeldis , Herbert Faleck , Donald Manning
IPC分类号： A61K31/4035 , A61K31/7048 , A61K31/60 , A61K31/573 , A61K31/55 , A61K31/445 , A61K31/485 , A61K31/192 , A61K31/4166 , A61K31/405 , A61K31/198
CPC分类号： A61K31/192 , A61K31/198 , A61K31/4035 , A61K31/405 , A61K31/4166 , A61K31/445 , A61K31/485 , A61K31/55 , A61K31/573 , A61K31/60 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译： 公开了治疗，预防，改变和管理各种疼痛的方法。 具体方法包括单独或与第二活性剂和/或手术，心理或物理疗法组合施用选择性细胞因子抑制药物或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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10.发明申请Methods of using and compositions comprising thalidomide for treatment, modification and management of fibromyalgia 审中-公开使用方法和包含沙利度胺的组合物用于治疗，改变和管理纤维肌痛公开(公告)号：US20050119194A1
公开(公告)日：2005-06-02
申请号：US10972311
申请日：2004-10-22
申请人： Jerome Zeldis , Herbert Faleck
发明人： Jerome Zeldis , Herbert Faleck
IPC分类号： A61K20060101 , A61K31/19 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/485 , A61K31/497 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/56 , A61K31/60 , A61K31/70 , A61K31/7048
CPC分类号： A61K31/70 , A61K31/19 , A61K31/415 , A61K31/445 , A61K31/454 , A61K31/497 , A61K31/551 , A61K31/553 , A61K31/56 , A61K31/60 , A61K2300/00
摘要： Methods of treating, preventing, modifying and/or managing fibromyalgia and related conditions are disclosed. Specific embodiments encompass the administration of thalidomide, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or physical or psychological therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in the methods of the invention are also disclosed.
摘要翻译： 公开了治疗，预防，改善和/或治疗纤维肌痛和相关病症的方法。 具体实施方案包括单独或与第二活性剂和/或物理或心理治疗组合施用沙利度胺或其药学上可接受的盐，溶剂合物，水合物，立体异构体，包合物或前药。 还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。
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