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1.发明申请Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders 审中-公开使用免疫调节化合物治疗横纹肌肉炎，多发性硬化症和其他疾病公开(公告)号：US20090155207A1
公开(公告)日：2009-06-18
申请号：US12324728
申请日：2008-11-26
IPC分类号： A61K38/21 , A61K31/56 , A61K31/445 , A61K39/395
CPC分类号： A61K31/00 , A61K31/454 , A61K31/573 , A61K38/212 , A61K38/215 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing or managing transverse myelitis, multiple sclerosis, and/or other disorders are disclosed. The methods encompass the administration of an immunomodulatory compound provided herein, such as 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl-piperidine-2,6-dione or 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline. Further described are methods of treatment using the immunomodulatory compounds in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
摘要翻译： 公开了治疗，预防或治疗横贯性脊髓炎，多发性硬化症和/或其它病症的方法。 所述方法包括给予本文提供的免疫调节化合物，例如3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基 - 哌啶-2,6-二酮或1,3-二氧代 -2-（2,6-二氧代哌啶-3-基）-4-氨基异吲哚啉进一步描述了使用免疫调节化合物与第二活性剂组合的治疗方法。适用于该方法的药物组合物和单一单位剂型 还公开了本文。
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2.发明授权Modulation of stem and progenitor cell differentiation, assays, and uses thereof 有权茎和祖细胞分化的调节，测定及其用途公开(公告)号：US08889411B2
公开(公告)日：2014-11-18
申请号：US12396397
申请日：2009-03-02
IPC分类号： C12N5/00 , C12N5/0789 , C12N5/0784 , C12N5/0787 , A61K35/12
CPC分类号： A61K31/454 , A61K2035/124 , C12N5/0639 , C12N5/0642 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/385 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
摘要翻译： 本发明涉及调节哺乳动物干细胞和祖细胞分化的方法。 本发明的方法可用于调节和控制特定细胞和组织谱系中哺乳动物，特别是人干细胞的分化和成熟。 本发明的方法涉及某些小有机分子在特定细胞和组织谱系中调节干细胞或祖细胞群的分化的用途，特别是涉及来源于产后胎盘的胚胎样干细胞的分化或 用于将早期祖细胞分化成粒细胞谱系。 最后，本发明涉及这种分化的干细胞或祖细胞在移植和其他医学治疗中的用途。
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3.发明申请MODULATION OF STEM AND PROGENITOR CELL DIFFERENTIATION, ASSAYS, AND USES THEREOF 有权干扰素和前体细胞分化的调节，其测定及其用途公开(公告)号：US20090226406A1
公开(公告)日：2009-09-10
申请号：US12396397
申请日：2009-03-02
CPC分类号： A61K31/454 , A61K2035/124 , C12N5/0639 , C12N5/0642 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/385 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
摘要翻译： 本发明涉及调节哺乳动物干细胞和祖细胞分化的方法。 本发明的方法可用于调节和控制特定细胞和组织谱系中哺乳动物，特别是人干细胞的分化和成熟。 本发明的方法涉及某些小有机分子在特定细胞和组织谱系中调节干细胞或祖细胞群的分化的用途，特别是涉及来源于产后胎盘的胚胎样干细胞的分化或 用于将早期祖细胞分化成粒细胞谱系。 最后，本发明涉及这种分化的干细胞或祖细胞在移植和其他医学治疗中的用途。
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4.发明授权Modulation of stem and progenitor cell differentiation, assays, and uses thereof 有权茎和祖细胞分化的调节，测定及其用途公开(公告)号：US07498171B2
公开(公告)日：2009-03-03
申请号：US10411655
申请日：2003-04-11
IPC分类号： C12N5/00
CPC分类号： A61K31/454 , A61K2035/124 , C12N5/0639 , C12N5/0642 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/385 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
摘要翻译： 本发明涉及调节哺乳动物干细胞和祖细胞分化的方法。 本发明的方法可用于调节和控制特定细胞和组织谱系中哺乳动物，特别是人干细胞的分化和成熟。 本发明的方法涉及某些小有机分子在特定细胞和组织谱系中调节干细胞或祖细胞群的分化的用途，特别是涉及来源于产后胎盘的胚胎样干细胞的分化或 用于将早期祖细胞分化成粒细胞谱系。 最后，本发明涉及这种分化的干细胞或祖细胞在移植和其他医学治疗中的用途。
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5.发明申请METHODS FOR TREATMENT OF COGNITIVE AND MENOPAUSAL DISORDERS WITH D-THREO METHYLPHENIDATE 审中-公开用甲基苯甲酸D-THREO治疗认知障碍和男性疾病的方法公开(公告)号：US20130053414A1
公开(公告)日：2013-02-28
申请号：US13661472
申请日：2012-10-26
申请人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
发明人： Jerome B. Zeldis , Herbert J. Faleck , Vikram Khetani , Andrew L. Zeitlin , Maghsoud M. Dariani , David I. Stirling
IPC分类号： A61K31/4458 , A61P25/00 , A61P25/24 , A61P3/00
CPC分类号： C07D211/34 , A61K31/4458 , A61K45/06 , C12P17/12 , C12P41/006 , A61K2300/00
摘要： In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the present invention is directed to methods for treating disorders related to menopause, including executive function defects. The methods involve the administration of a composition comprising D-threo methylphenidate that is substantially free of L-threo methylphenidate and of erythro forms of methylphenidate.
摘要翻译： 一方面，本发明涉及用于治疗疲劳，神经行为减缓以及由于与癌症相关的癌症和治疗以及类似病症引起的其他认知障碍和缺陷的方法。 在另一方面，本发明涉及治疗与绝经相关的疾病的方法，包括执行功能缺陷。 所述方法包括施用包含基本上不含L-苏雷哌甲酯的D-苏雷哌甲酯和红皮质哌甲酯的组合物。
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公开(公告)号：US07005438B2
公开(公告)日：2006-02-28
申请号：US10732858
申请日：2003-12-09
申请人： George Muller , Hon-Wah Man , David I. Stirling
发明人： George Muller , Hon-Wah Man , David I. Stirling
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , C07D405/14
摘要： Isoindolin-1-one and Isoindoline-1,3-dione substituted in the 2-position with a 2,6-dioxo-3-hydroxypiperidin-5-yl group, which may be further substituted in the 5-position with alkyl or halogeno, and in the 4-position with alkyl or a nitrogen-containing group are inhibitors of, and thus useful in the treatment of disease states mediated by, TNFα. A typical embodiment is 2-(2,6-dioxo-3-hydroxy-5-fluoropiperidin-5-yl)-4-aminoisoindolin-1-one.
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公开(公告)号：US06316471B1
公开(公告)日：2001-11-13
申请号：US09634061
申请日：2000-10-17
IPC分类号： A61K31454
CPC分类号： A61K31/445 , C07D401/04 , Y10S514/825 , Y10S514/886 , Y10S514/908
摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF&agr; in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
摘要翻译： 取代的2-（2,6-二氧代哌啶-3-基）苯二酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉降低哺乳动物TNFalpha的水平。 典型的实例是1-氧代-2-（2,6-二氧代-3-甲基哌啶-3-基）-4,5,6,7-四氟异二氢吲哚和1,3-二氧代-2-（2,6-二氧代 - 3-甲基哌啶-3-基）-4-氨基异二氢吲哚。
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公开(公告)号：US5300437A
公开(公告)日：1994-04-05
申请号：US959147
申请日：1992-10-09
CPC分类号： C12N9/1096 , C12P41/006 , C12P7/26
摘要： Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
摘要翻译： 其中氨基在手性取代的仲碳原子上的胺可通过ω-氨基酸转氨酶的作用而被对映体富集，该氨基酸转氨酶具有优先将两种手性形式之一转化为酮的性质。 该方法还可以用于立体选择性地从酮中合成一种手性形式，基本上排除另一种。
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9.发明申请Method Of Treating Attention Deficit Disorders With D-Threo Methylphenidate 审中-公开用D-Threo哌甲酯治疗注意力缺陷障碍的方法公开(公告)号：US20110201645A1
公开(公告)日：2011-08-18
申请号：US13093917
申请日：2011-04-26
IPC分类号： A61K31/4458 , A61P25/00
CPC分类号： A61K31/445 , A61K9/1676 , A61K9/2886 , A61K9/5078 , A61K9/5084 , A61K31/4458 , C07D211/34 , C12P17/12 , C12P41/006
摘要： Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while minimizing drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential by administration of d-threo-methylphenidate or pharmaceutically acceptable salts thereof.
摘要翻译： 治疗注意力缺陷障碍，注意力缺陷多动障碍，艾滋病痴呆综合征和艾滋病毒/艾滋病认知衰退的方法，同时通过施用二硫代哌甲酯或药学上可接受的方式尽量减少药物过敏反应，毒性，副作用，欣欣乐效和药物滥用潜力 的盐。
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公开(公告)号：US07629360B2
公开(公告)日：2009-12-08
申请号：US11280333
申请日：2005-11-17
IPC分类号： A61K31/445
CPC分类号： C07D401/04 , A61K31/454
摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.
摘要翻译： 公开了取代的2-（2,6-二氧代哌啶-3-基）邻苯二酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉。 所述化合物可用于例如降低哺乳动物中TNFα的水平。
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