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1.发明授权Methods of identifying modulators of a cold-and-menthol-sensitive receptor (CMR1) and recombinant cells for use thereof 有权识别冷和薄荷醇敏感受体（CMR1）的调节剂和用于其的重组细胞的方法公开(公告)号：US08361733B2
公开(公告)日：2013-01-29
申请号：US12905001
申请日：2010-10-14
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US20080241872A1
公开(公告)日：2008-10-02
申请号：US12032485
申请日：2008-02-15
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
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3.发明授权Methods of modulating cold sensory perception via a cold- and menthol-sensitive receptor (CMR1) 有权通过冷和薄荷醇敏感受体（CMR1）调节感冒感觉的方法公开(公告)号：US08470545B2
公开(公告)日：2013-06-25
申请号：US13340443
申请日：2011-12-29
IPC分类号： G01N33/53 , G01N33/567 , C12Q1/02 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US07834150B2
公开(公告)日：2010-11-16
申请号：US12032287
申请日：2008-02-15
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US20120100076A1
公开(公告)日：2012-04-26
申请号：US13340443
申请日：2011-12-29
IPC分类号： A61K49/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US20080242841A1
公开(公告)日：2008-10-02
申请号：US12032287
申请日：2008-02-15
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US20110053137A1
公开(公告)日：2011-03-03
申请号：US12905001
申请日：2010-10-14
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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8.发明授权Methods of modulating cold sensory perception via a cold- and menthol-sensitive receptor (CMR1) 有权通过冷和薄荷醇敏感受体（CMR1）调节感冒感觉的方法公开(公告)号：US07838253B2
公开(公告)日：2010-11-23
申请号：US12032485
申请日：2008-02-15
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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公开(公告)号：US07371841B2
公开(公告)日：2008-05-13
申请号：US10352724
申请日：2003-01-27
IPC分类号： C07K14/435 , C07K14/705 , C07H21/04 , C12N15/09 , C12N15/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12N15/00 , C12N15/09 , G01N33/5041 , G01N33/58 , G01N2333/705
摘要： The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods for identifying and using agents that modulate cold responses and pain responses stimulated by cold via modulation of CMR1 and CMR1-related signal transduction.
摘要翻译： 本发明涉及冷感和疼痛的调节。 更具体地，本发明涉及编码瞬时调节蛋白家族CMR1的成员的核酸，其涉及冷感觉和疼痛的感知的调节。 本发明还涉及用于鉴定和使用调节由CMR1和CMR1相关信号转导的冷经过调节而产生的冷反应和疼痛反应的药剂的方法。
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