公开(公告)号：US07265260B2

公开(公告)日：2007-09-04

申请号：US10378393

申请日：2003-03-03

申请人： David K. Bol ,  Joan M. Carboni ,  Ronald B. Rowley ,  Tai W. Wong ,  Francis Y. Lee

发明人： David K. Bol ,  Joan M. Carboni ,  Ronald B. Rowley ,  Tai W. Wong ,  Francis Y. Lee

IPC分类号： A01K67/027 ,  A01K67/00 ,  C07H21/04

CPC分类号： C07K14/72 ,  A01K67/0271 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K2319/70 ,  C12N15/8509 ,  C12N2517/02

摘要： A transgenic non-human mammal whose germ cells and somatic cells contain a constructively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-independent in vivo models for the identification and development of selective tyrosine kinase modulators for the treatment of cancer.

摘要翻译： 一种转基因非人哺乳动物，其生殖细胞和体细胞在胚胎期含有引入哺乳动物或哺乳动物祖先的结构活化的酪氨酸激酶受体。 转基因非人哺乳动物可以用作体内独立体内模型，用于鉴定和开发用于治疗癌症的选择性酪氨酸激酶调节剂。

公开(公告)号：US08124729B2

公开(公告)日：2012-02-28

申请号：US11891240

申请日：2007-08-09

申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David K. Bol ,  Donald R. Hawken

发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David K. Bol ,  Donald R. Hawken

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C12P21/06 ,  C12N1/20 ,  C12N15/74

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US06534531B2

公开(公告)日：2003-03-18

申请号：US09842595

申请日：2001-04-26

申请人： S. David Kimball ,  Kevin R. Webster ,  David K. Bol

发明人： S. David Kimball ,  Kevin R. Webster ,  David K. Bol

IPC分类号： A61K31425

CPC分类号： C07D417/12 ,  A61K31/427 ,  A61K31/454 ,  C07D417/14

摘要： The invention provides a method for preventing or treating alopecia induced by chemotherapy or radiotherapy by administering to a mammalian specie in need thereof a therapeutically effective amount of a compound of formula I or II or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了一种预防或治疗由化学疗法或放射治疗引起的脱发的方法，其通过向有需要的哺乳动物物种施用治疗有效量的式I或II化合物或其药学上可接受的盐。

公开(公告)号：US07635758B2

公开(公告)日：2009-12-22

申请号：US11890963

申请日：2007-08-08

申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David K. Bol

发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David K. Bol

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20080318257A1

公开(公告)日：2008-12-25

申请号：US12220155

申请日：2008-07-22

申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Michael A. Blanar ,  David K. Bol ,  Paul C. Levesque ,  Lucy Sun

发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Michael A. Blanar ,  David K. Bol ,  Paul C. Levesque ,  Lucy Sun

IPC分类号： G01N33/53 ,  C07K16/18 ,  C12N5/06 ,  G01N33/566

CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622

摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

公开(公告)号：US07049088B2

公开(公告)日：2006-05-23

申请号：US10164278

申请日：2002-06-05

申请人： Lori Friedman ,  Gregory D. Plowman ,  Marcia Belvin ,  Helen Francis-Lang ,  Danxi Li ,  Roel P. Funke ,  Rolf Peter Ryseck ,  Lata Jayaraman ,  David K. Bol ,  Matthew Lorenzi

发明人： Lori Friedman ,  Gregory D. Plowman ,  Marcia Belvin ,  Helen Francis-Lang ,  Danxi Li ,  Roel P. Funke ,  Rolf Peter Ryseck ,  Lata Jayaraman ,  David K. Bol ,  Matthew Lorenzi

IPC分类号： C12Q1/48 ,  C12N9/10

CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2333/4739 ,  G01N2500/10

摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.