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    COATED MEDICAL IMPLANTS AND LENSES
    3.
    发明申请
    COATED MEDICAL IMPLANTS AND LENSES 审中-公开
    涂层医用植绒和镜片

    公开(公告)号：US20080208334A1

    公开(公告)日：2008-08-28

    申请号：US12038030

    申请日：2008-02-27

    申请人： David L. Jinkerson ,  Mutlu Karakelle

    发明人： David L. Jinkerson ,  Mutlu Karakelle

    IPC分类号： A61F2/16 ,  A61F2/02

    CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10

    摘要： Coated medical implants have an implant body configured for securing in or adjacent to body tissue of a patient. The implant body has an implant surface and a coating is formed on at least a portion of the implant surface. The coating includes a coating outer surface of a first chemical component that is chemically bonded to a carboxylate functionality of a second chemical component. The second chemical component is immobilized by amide linkage to an underlying third chemical component that is plasma coated directly onto implant body surfaces. The coating either inhibits or prevents the adhesion of protein and/or cellular proliferation or may be a non-fouling coating.

    摘要翻译： 涂覆的医疗植入物具有构造成用于固定在患者身体组织中或邻近患者身体组织的植入体。 植入体具有植入物表面，并且在植入物表面的至少一部分上形成涂层。 涂层包括化学键合到第二化学组分的羧酸官能团的第一化学组分的涂层外表面。 第二种化学成分通过酰胺键固定在下面的第三种化学成分上，其等离子体涂覆在植入体表面上。 该涂层可抑制或防止蛋白质和/或细胞增殖的粘附，或者可以是非结垢的涂层。

    High refractive index ophthalmic lens materials
    4.
    发明授权
    High refractive index ophthalmic lens materials 失效
    高折射率眼科镜片材料

    公开(公告)号：US5693095A

    公开(公告)日：1997-12-02

    申请号：US739245

    申请日：1996-10-29

    申请人： Charles Freeman ,  David L. Jinkerson ,  Mutlu Karakelle ,  Albert R. LeBoeuf

    发明人： Charles Freeman ,  David L. Jinkerson ,  Mutlu Karakelle ,  Albert R. LeBoeuf

    IPC分类号： A61L27/00 ,  A61L27/16 ,  C08F2/44 ,  C08F220/10 ,  C08F220/16 ,  C08F220/18 ,  C08F220/30 ,  C08F220/34 ,  C08F220/38 ,  G02B1/04 ,  A61F2/16 ,  C08F26/06 ,  G02C7/04

    CPC分类号： A61F2/16 ,  A61L27/16 ,  C08F220/18 ,  C08F220/30 ,  G02B1/043 ,  A61L2430/16

    摘要： Improved soft, foldable acrylic lens materials which are particularly suited for use as IOLs, but which are also useful as other ophthalmic devices, such as contact lenses, keratoprostheses, and corneal rings or inlays, are disclosed. These materials contain only two principal components: one aryl acrylic hydrophobic monomer and one hydrophilic monomer. The materials of the present invention are copolymers comprising at least about 90% by weight of the two principal monomeric components; provided that the amount of the hydrophilic component is not greater than that of the aryl acrylic hydrophobic component. The remainder of the material comprises up to 10% by weight of one or more additional components, such as cross-linking, UV-light absorbing, and blue-light absorbing components. The aryl acrylic hydrophobic monomers suitable for use in the materials of the present invention have the formula ##STR1## wherein: X is H or CH.sub.3 ; m is 0-6; Y is nothing, O, S, or NR, wherein R is H, CH.sub.3, C.sub.n H.sub.2n+1 (n=1-10), iso-OC.sub.3 H.sub.7, C.sub.6 H.sub.5, or CH.sub.2 C.sub.6 H.sub.5 ; and Ar is any aromatic ring which can be unsubstituted or substituted with H, CH.sub.3, C.sub.2 H.sub.5, n-C.sub.3 H.sub.7, iso-C.sub.3 H.sub.7, OCH.sub.3, C.sub.6 H.sub.11, Cl, Br, C.sub.6 H.sub.5, or CH.sub.2 C.sub.6 H.sub.5.

    摘要翻译： 公开了改进的柔软的，可折叠的丙烯酸类镜片材料，其特别适合用作IOL，但也可用作其它眼科装置，例如隐形眼镜，角膜假体和角膜环或嵌体。 这些材料仅含有两种主要成分：一种芳基丙烯酸疏水单体和一种亲水单体。 本发明的材料是包含至少约90重量％的两种主要单体组分的共聚物; 只要亲水组分的量不大于芳基丙烯酸疏水组分的量。 剩余的材料包含至多10重量％的一种或多种另外的组分，例如交联，UV光吸收和蓝光吸收组分。 适用于本发明材料的芳基丙烯酸类疏水性单体具有下式：其中：X为H或CH 3; m为0-6; Y不为O，S或NR，其中R为H，CH 3，C n H 2n + 1（n = 1-10），异OC 3 H 7，C 6 H 5或CH 2 C 6 H 5; Ar可以是未被取代或被H，CH 3，C 2 H 5，n-C 3 H 7，异-C 3 H 7，OCH 3，C 6 H 11，Cl，Br，C 6 H 5或CH 2 C 6 H 5取代的任何芳香环。

    High refractive index ophthalmic device materials
    5.
    发明授权
    High refractive index ophthalmic device materials 有权
    高折射率眼科装置材料

    公开(公告)号：US06353069B1

    公开(公告)日：2002-03-05

    申请号：US09536083

    申请日：2000-03-24

    申请人： Charles Freeman ,  David L. Jinkerson ,  Mutlu Karakelle ,  Albert R. Leboeuf

    发明人： Charles Freeman ,  David L. Jinkerson ,  Mutlu Karakelle ,  Albert R. Leboeuf

    IPC分类号： A61F216

    CPC分类号： G02B1/043 ,  C08L33/06 ,  C08L33/14

    摘要： High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise a) two or more monomers of the structure: wherein: X is H or CH3; m is 0-10; Y is nothing, O, S, or NR wherein R is H, CH3, CnH2n+1(n=1-10), iso-OC3H7, C6H5, or CH2C6H5; Ar is any aromatic ring which can be unsubstituted or substituted with H, CH3, C2H5, n-C3H7, iso-C3H7, OCH3, C6H11, Cl, Br, C6H5, or CH2C6H5; a crosslinking monomer having a plurality of polymerizable ethylenically unsaturated groups, and b) a total of about 5 mole % or less of one or more monomers of the structure: wherein: X is H or CH3; W is —CH3 or (CH2═C(—X)—C(═O)—); and n is such that the weight average molecular weight is approximately 600-1000 if W is —CH3 and approximately 400-1000 if W is (CH2═C(—X)—C(═O)—).

    摘要翻译： 公开了适用于眼科装置的高折射率共聚物。 共聚物包含a）两种或更多种结构单体：其中：X是H或CH3; m是0-10; Y不是O，S或NR，其中R是H，CH 3，C n H 2n + 1（n = 1-10），异OC 3 H 7，C 6 H 5或CH 2 C 6 H 5; Ar是可以是未取代的或被H，CH 3，C 2 H 5，n-C 3 H 7，异-C 3 H 7，OCH 3，C 6 H 11，Cl，Br，C 6 H 5， 或CH 2 C 6 H 5;具有多个可聚合烯属不饱和基团的交联单体，和b）总共约5摩尔％以下的一种或多种结构单体：其中：X为H或CH 3; W为-CH 3或（CH 2 = C（-X）-C（= O） - ）; 并且如果W是（CH 2 = C（-X）-C（= O） - ），则W是-CH 3，重均分子量约为600-1000，如果W是（CH 2 = C（-X）-C（= O） - ）），则重均分子量约为600-1000。