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    SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE
    1.
    发明申请
    SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
    用于在眼睛中进行交叉连接的系统和方法

    公开(公告)号：US20110288466A1

    公开(公告)日：2011-11-24

    申请号：US13086019

    申请日：2011-04-13

    申请人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    发明人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    IPC分类号： A61M37/00

    CPC分类号： A61K31/525 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61N5/062

    摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.

    摘要翻译： 激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。 通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。 本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。 方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

    CONTROLLED APPLICATION OF CROSS-LINKING AGENT
    2.
    发明申请
    CONTROLLED APPLICATION OF CROSS-LINKING AGENT 审中-公开
    交联剂的控制应用

    公开(公告)号：US20120289886A1

    公开(公告)日：2012-11-15

    申请号：US13475175

    申请日：2012-05-18

    申请人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    发明人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    IPC分类号： A61M37/00

    CPC分类号： A61K31/525 ,  A61F9/0079 ,  A61F9/008 ,  A61F9/00804 ,  A61F2009/00844 ,  A61F2009/00851 ,  A61F2009/00853 ,  A61F2009/00857 ,  A61F2009/00872

    摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.

    摘要翻译： 激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。 通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。 本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。 方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

    SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY
    3.
    发明申请
    SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 审中-公开
    用于应用和监测眼睛治疗的系统和方法

    公开(公告)号：US20110237999A1

    公开(公告)日：2011-09-29

    申请号：US13051699

    申请日：2011-03-18

    申请人： David Muller ,  John Marshall ,  Marc D. Friedman ,  Stephen Blinn ,  Ronald Scharf ,  Pavel Kamaev ,  Radha Pertaub

    发明人： David Muller ,  John Marshall ,  Marc D. Friedman ,  Stephen Blinn ,  Ronald Scharf ,  Pavel Kamaev ,  Radha Pertaub

    IPC分类号： A61F9/007 ,  A61B3/10

    摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

    摘要翻译： 用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。 提供反馈系统以获取测量并将反馈信息传递给控制器​​。 反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。 该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。 还提供反馈系统的方面来监测和诊断眼睛的特征1.还提供了根据由反馈系统提供的信息激活交联以提高交联疗法的准确性和安全性的方法。

    System and method for stabilizing corneal tissue after treatment
    7.
    发明授权
    System and method for stabilizing corneal tissue after treatment 失效
    治疗后稳定角膜组织的系统和方法

    公开(公告)号：US08177778B2

    公开(公告)日：2012-05-15

    申请号：US12915646

    申请日：2010-10-29

    申请人： David Muller ,  John Marshall

    发明人： David Muller ,  John Marshall

    IPC分类号： A61B18/02

    CPC分类号： A61F9/007 ,  A61B18/1815 ,  A61B2018/00029 ,  A61F9/0079 ,  A61F9/013 ,  A61F2009/00872 ,  A61K38/1841 ,  A61M35/00 ,  A61M2210/0612

    摘要： Systems and methods stabilize corneal tissue after treatment of the corneal tissue. For example, thermokeratoplasty may be applied to the corneal tissue to address disorders associated with abnormal shaping of the cornea. To stabilize the desired structural changes caused by the treatment, embodiments apply ophthalmic formulations that help to inhibit wound healing. Wound healing may occur in response to the application of the treatment and may produce further structural changes that mitigate or alter the desired effects of the treatment.

    摘要翻译： 系统和方法在角膜组织治疗后稳定角膜组织。 例如，热角膜成形术可以应用于角膜组织以解决与角膜异常成形相关的疾病。 为了稳定由治疗引起的期望的结构变化，实施方案应用有助于抑制伤口愈合的眼用制剂。 伤口愈合可能会因应用治疗而发生，并可能产生进一步的结构变化，从而减轻或改变预期的治疗效果。

    Multimodal Ocular Biometric System
    8.
    发明申请
    Multimodal Ocular Biometric System 有权
    多模眼睛生物识别系统

    公开(公告)号：US20110285836A1

    公开(公告)日：2011-11-24

    申请号：US13196617

    申请日：2011-08-02

    申请人： Marc D. Friedman ,  Pablo Casaverde ,  Don Yansen ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  Nicholas A. Accomando ,  David Muller ,  Greg Heacock ,  John Marshall

    发明人： Marc D. Friedman ,  Pablo Casaverde ,  Don Yansen ,  Tim McNerney ,  Yasunari Tosa ,  David Usher ,  Nicholas A. Accomando ,  David Muller ,  Greg Heacock ,  John Marshall

    IPC分类号： H04N7/18

    CPC分类号： H04N7/18 ,  A61B3/1216 ,  A61B3/14 ,  G06K9/00597

    摘要： A multimodal biometric identification system captures and processes images of both the iris and the retina for biometric identification. Another multimodal ocular system captures and processes images of the iris and/or the from both eyes of a subject. Biometrics based on data provided by these systems are more accurate and robust than using biometrics that include data from only the iris or only the retina from a single eye. An exemplary embodiment emits photons to the iris and the retina of both eyes, an iris image sensor that captures an image of the iris when the iris reflects the emitted light, a retina image sensor that captures an image of the retina when the retina reflects the emitted light, and a controller that controls the iris and the retina illumination sources, where the captured image of the iris and the captured image of the retina contain biometric data.

    摘要翻译： 多模式生物识别系统捕获并处理虹膜和视网膜的图像以进行生物识别。 另一个多模态眼系统捕获并处理虹膜和/或从受试者的双眼的图像。 基于这些系统提供的数据的生物识别技术比使用仅包括虹膜的数据或仅来自单个眼睛的视网膜的生物识别技术更准确和鲁棒。 示例性实施例将光子发射到虹膜和双眼视网膜，虹膜图像传感器，当虹膜反射发射的光时捕获虹膜的图像;视网膜图像传感器，其在视网膜反射时捕获视网膜的图像 以及控制虹膜和视网膜照明源的控制器，其中虹膜的捕获图像和视网膜的捕获图像包含生物特征数据。

    EYE THERAPY SYSTEM
    9.
    发明申请
    EYE THERAPY SYSTEM 失效
    眼睛治疗系统

    公开(公告)号：US20100094197A1

    公开(公告)日：2010-04-15

    申请号：US12570959

    申请日：2009-09-30

    申请人： John Marshall ,  Ali Hussein ,  David Muller

    发明人： John Marshall ,  Ali Hussein ,  David Muller

    IPC分类号： A61F9/013

    CPC分类号： A61F9/008 ,  A61F9/0079 ,  A61F9/009 ,  A61F2009/00853 ,  A61F2009/00872

    摘要： In a system for stabilizing a pattern of structural changes in corneal fibrils, an eye treatment system causes corneal fibrils of a cornea of an eye to transition from a first structure to a second structure. An application device applies a cross-linking element to the corneal fibrils. An activating device applies an initiating element to the corneal fibrils and activates the cross-linking element. The cross-linking element causes cross-linking in the corneal fibrils to preserve the second structure of the corneal fibrils. Another application device may apply a cross-linking breaker to the corneal fibrils. The cross-linking breaker halts or reverses at least partially the cross-linking in the corneal fibrils. Another activating device applies an initiating element to the corneal fibrils and activates the cross-linking breaker. Advantageously, the cross-linking breaker provides greater control over the amount and progress of cross-linking that occurs in the corneal fibrils.

    摘要翻译： 在用于稳定角膜原纤维结构变化的模式的系统中，眼睛治疗系统使眼睛角膜的角膜原纤维从第一结构转变到第二结构。 应用装置将交联元件应用于角膜原纤维。 激活装置将起始元件施加到角膜原纤维并激活交联元件。 交联元件引起角膜原纤维中的交联以保留角膜原纤维的第二结构。 另一应用装置可以将交联断路器应用于角膜原纤维。 交联断路器至少部分地停止或逆转角膜原纤维中的交联。 另一激活装置将起始元件施加到角膜原纤维并激活交联断路器。 有利地，交联断路器对角膜原纤维中发生的交联的量和进展提供更大的控制。

    Eye therapy
    10.
    发明授权
    Eye therapy 有权
    眼科治疗

    公开(公告)号：US08574277B2

    公开(公告)日：2013-11-05

    申请号：US12909228

    申请日：2010-10-21

    申请人： David Muller ,  John Marshall ,  Marc D. Friedman

    发明人： David Muller ,  John Marshall ,  Marc D. Friedman

    IPC分类号： A61N5/06 ,  A61F9/00

    CPC分类号： A61N5/062 ,  A61F9/0008 ,  A61F9/013 ,  A61K31/14

    摘要： Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O2 into singlet oxygen which causes cross-linking within the corneal tissue. The rate of cross-linking in the cornea is related to the concentration of O2 present when the cross-linking agent is irradiated with photoactivating light. Accordingly, the embodiments control the concentration of O2 during irradiation to increase or decrease the rate of cross-linking and achieve a desired amount of cross-linking.

    摘要翻译： 实施例将交联剂应用于角膜组织的区域。 交联剂改善了角膜组织抵抗不良结构变化的能力。 例如，交联剂可以是核黄素或玫瑰红，并且起始元件可以是光活化的光，例如紫外（UV）光。 在这些实施方案中，光活化光通过照射施加的交联剂以释放角膜组织中的活性氧自由基引发交联活性。 交联剂作为敏化剂将O 2转化成单线态氧，导致角膜组织内的交联。 角膜中的交联速率与交联剂用光活化光照射时存在的O 2浓度有关。 因此，实施例控制照射期间的O 2浓度以增加或降低交联速率并达到所需量的交联。