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    SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE
    1.
    发明申请
    SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
    用于在眼睛中进行交叉连接的系统和方法

    公开(公告)号：US20110288466A1

    公开(公告)日：2011-11-24

    申请号：US13086019

    申请日：2011-04-13

    申请人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    发明人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    IPC分类号： A61M37/00

    CPC分类号： A61K31/525 ,  A61F9/008 ,  A61F2009/00844 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61N5/062

    摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.

    摘要翻译： 激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。 通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。 本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。 方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

    CONTROLLED APPLICATION OF CROSS-LINKING AGENT
    2.
    发明申请
    CONTROLLED APPLICATION OF CROSS-LINKING AGENT 审中-公开
    交联剂的控制应用

    公开(公告)号：US20120289886A1

    公开(公告)日：2012-11-15

    申请号：US13475175

    申请日：2012-05-18

    申请人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    发明人： David Muller ,  John Marshall ,  Stephen L. Trokel ,  Peter Hersh ,  Pavel Kamaev

    IPC分类号： A61M37/00

    CPC分类号： A61K31/525 ,  A61F9/0079 ,  A61F9/008 ,  A61F9/00804 ,  A61F2009/00844 ,  A61F2009/00851 ,  A61F2009/00853 ,  A61F2009/00857 ,  A61F2009/00872

    摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.

    摘要翻译： 激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。 通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。 本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。 方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

    SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY
    3.
    发明申请
    SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 审中-公开
    用于应用和监测眼睛治疗的系统和方法

    公开(公告)号：US20110237999A1

    公开(公告)日：2011-09-29

    申请号：US13051699

    申请日：2011-03-18

    申请人： David Muller ,  John Marshall ,  Marc D. Friedman ,  Stephen Blinn ,  Ronald Scharf ,  Pavel Kamaev ,  Radha Pertaub

    发明人： David Muller ,  John Marshall ,  Marc D. Friedman ,  Stephen Blinn ,  Ronald Scharf ,  Pavel Kamaev ,  Radha Pertaub

    IPC分类号： A61F9/007 ,  A61B3/10

    摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

    摘要翻译： 用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。 提供反馈系统以获取测量并将反馈信息传递给控制器​​。 反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。 该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。 还提供反馈系统的方面来监测和诊断眼睛的特征1.还提供了根据由反馈系统提供的信息激活交联以提高交联疗法的准确性和安全性的方法。

    SYSTEM AND METHOD OF TREATING TISSUE WITH ULTRASOUND ENERGY
    8.
    发明申请
    SYSTEM AND METHOD OF TREATING TISSUE WITH ULTRASOUND ENERGY 审中-公开
    用超声能量治疗组织的系统和方法

    公开(公告)号：US20100298744A1

    公开(公告)日：2010-11-25

    申请号：US12771558

    申请日：2010-04-30

    申请人： Gregory B. Altshuler ,  Christopher Gaal ,  Pavel Kamaev ,  Oldrich M. Laznicka, JR. ,  Ilya Yaroslavsky

    发明人： Gregory B. Altshuler ,  Christopher Gaal ,  Pavel Kamaev ,  Oldrich M. Laznicka, JR. ,  Ilya Yaroslavsky

    IPC分类号： A61N7/02

    CPC分类号： A61N7/02 ,  A61N2007/0039 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0082

    摘要： Disclosed herein are method(s) and device(s) capable of generating a small lesion as deep as a few millimeters beneath the skin's surface and several cubic millimeters in volume in orders of magnitude less time, namely, tens of milliseconds. More specifically, in one exemplary embodiment, a method of treating tissue (e.g., skin) is provided which includes generating one or more ultrasound pulses with each pulse having a pulse width shorter than a thermal relaxation time of a tissue treatment volume, and applying one or more of said ultrasound pulses to at least one portion of the tissue treatment volume to generate one or more treatment areas in a region. Methods of treating tissue can include effecting a therapeutic treatment in said region of the tissue, and/or effecting a cosmetic treatment in said target region.

    摘要翻译： 本文公开了能够产生皮肤表面下方几毫米深的几个立方毫米体积的小损伤的方法和装置，其数量级更小的时间，即几十毫秒。 更具体地，在一个示例性实施例中，提供了一种治疗组织（例如皮肤）的方法，其包括产生一个或多个超声脉冲，其中每个脉冲的脉冲宽度短于组织处理体积的热松弛时间，并且应用一个 或更多的所述超声波脉冲施加到组织处理体积的至少一部分以在区域中产生一个或多个治疗区域。 治疗组织的方法可以包括在组织的所述区域进行治疗性治疗，和/或在所述靶区域进行美容治疗。