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公开(公告)号：US06454193B1
公开(公告)日：2002-09-24
申请号：US09553541
申请日：2000-04-20
IPC分类号： B05B500
CPC分类号： A61L9/14 , A61M1/265 , A61M15/02 , B05B5/0255
摘要： A electrohydrodynamic aerosol sprayer wherein a gas flow deflector is used for creating a gas flow past the spray nozzle to stabilize the Taylor cone and to transport at least a portion of the aerosol away from the region downstream of the spray nozzle. This stabilization of the cone and transport of aerosol improves the droplet size and distribution and may also reduce the deposit of droplets on the internal components of the device.
摘要翻译： 一种电动液体喷雾器，其中气体导流器用于产生通过喷嘴的气流，以稳定泰勒锥并将至少一部分气溶胶运送到远离喷雾喷嘴下游的区域。 锥体的稳定化和气溶胶的输送改善了液滴的尺寸和分布，并且还可以减少液滴在装置的内部部件上的沉积。
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公开(公告)号：US07849850B2
公开(公告)日：2010-12-14
申请号：US10375957
申请日：2003-02-28
申请人： William G. Atterbury , Chad E. Bouton , David R. Busick , James E. Dvorsky , Peter A. Gaydos , David A. Holley , Daniel D. Meek , Gregory A. Trees
发明人： William G. Atterbury , Chad E. Bouton , David R. Busick , James E. Dvorsky , Peter A. Gaydos , David A. Holley , Daniel D. Meek , Gregory A. Trees
CPC分类号： A61M15/02 , A61M11/001 , B05B1/18 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/1691
摘要： An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.
摘要翻译： 特别适用于手持式肺气溶胶吸入器的改进的电动力学（EHD）喷嘴通过减少或消除通过屏蔽放电电极的润湿来增加治疗液体的一致和有效的分配。 一些版本进一步消除了润湿，同时通过环绕环绕气溶胶的离子的电晕放电来增强气溶胶的中和。 将具有一致的压降的改进的液体分布结合到每个EHD喷嘴尖端允许水平分配，并且通过使用具有低表面能的介电喷嘴尖端，从而避免分配之间的芯吸，并且有利地减少分配时可实现的粒度。 某些版本具有增强的卡扣配合和其他可制造性优势。 EHD喷嘴的独特特征之一是实现高剂量率（微升/分钟），具有低润湿和小粒径（1.0-5微米），尽管这些性质倾向于相互排斥。 此外，这些属性被并入到便利的小型手持设备中。
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公开(公告)号：US06796303B2
公开(公告)日：2004-09-28
申请号：US10161545
申请日：2002-06-03
IPC分类号： A61M1100
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.
摘要翻译： 一种用于将具有治疗性质的雾化液体输送到使用者的肺的装置和方法。 紧凑且方便的装置包括这样的尺寸的壳体，使得其可以在使用者的一只手中保持在壳体中的出口，用于将气溶胶引导到使用者的嘴部。 壳体包围用于容纳要雾化的液体并将其输送到电动力学装置的分配系统和用于使液体雾化并将气溶胶输送到出口的电动液压装置。 电动力学装置产生具有单分散的可呼吸液滴尺寸和接近零速度的雾化液滴云。 雾化装置包括多个喷射部位，每个喷射部分具有尖端，喷射部位与电荷源配合，以产生从至少一个末端到下游的多个放电电极的雾化喷雾，以及多个 的多个放电电极下游的参考电极。
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公开(公告)号：US06397838B1
公开(公告)日：2002-06-04
申请号：US09469042
申请日：1999-12-21
IPC分类号： A61M1100
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.
摘要翻译： 一种用于将具有治疗性质的雾化液体输送到使用者的肺的装置和方法。 紧凑且方便的装置包括这样的尺寸的壳体，使得其可以在使用者的一只手中保持在壳体中的出口，用于将气溶胶引导到使用者的嘴部。 壳体包围用于容纳要雾化的液体并将其输送到电动力学装置的分配系统和用于使液体雾化并将气溶胶输送到出口的电动液压装置。 电动力学装置产生具有单分散的可呼吸液滴尺寸和接近零速度的雾化液滴云。 雾化装置包括多个喷射部位，每个喷射部分具有尖端，喷射部位与电荷源配合，以产生从至少一个末端到下游的多个放电电极的雾化喷雾，以及多个 的多个放电电极下游的参考电极。
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公开(公告)号：US09289550B1
公开(公告)日：2016-03-22
申请号：US11385448
申请日：2006-03-20
CPC分类号： A61M5/16836 , A61B5/03 , A61B5/0507 , A61B5/4878 , A61B2562/04 , A61M5/007 , A61M2205/3313 , A61M2205/3375 , G01N22/00 , Y10S128/13
摘要： An apparatus for the detection of extravasation of an injection fluid infused into a tissue during an imaging procedure is disclosed. The apparatus includes at least a first source of energy to supply an X-ray or gamma ray imaging energy to tissue in the vicinity of a site and at least a first sensor to measure an energy signal resulting from the energy supplied to the tissue by the first imaging energy source, and circuitry configured to compare the energy signal detected by the first sensor to a baseline measurement and provide an alert that extravasation is occurring.
摘要翻译： 公开了一种用于在成像过程期间检测注入到组织中的注射液的外渗的装置。 该装置包括至少第一能量源，以将X射线或γ射线成像能量提供给场所附近的组织和至少第一传感器，以测量由所述组织供应的能量而产生的能量信号 第一成像能量源和被配置为将由第一传感器检测到的能量信号与基线测量进行比较并且提供正在发生外渗的警报的电路。
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公开(公告)号：US07798420B2
公开(公告)日：2010-09-21
申请号：US11351832
申请日：2006-02-10
CPC分类号： A61M15/02 , A61M11/001 , B05B5/0255 , B05B5/0533 , B05B5/1691
摘要： A method for delivering an aerosol, especially an aromatic aerosol, comprising the steps of contacting a capillary wick, comprising an EHD comminution site, with a liquid source, whereby at least a portion of the liquid transports to the EHD comminution site; applying a voltage to the liquid within the capillary wick at a location spaced apart from the liquid source and proximate the EHD comminution site; and applying a ground reference at a location external to the EHD comminution site, wherein at least a portion of the liquid EHD comminutes to form a spray having a generally-consistent flowrate and a device therefor.
摘要翻译： 一种用于递送气溶胶，特别是芳族气溶胶的方法，包括以下步骤：使包含EHD粉碎部位的毛细管芯与液体源接触，由此至少一部分液体输送到EHD粉碎部位; 在与液体源间隔开并且靠近EHD粉碎部位的位置向毛细管芯内的液体施加电压; 以及在所述EHD粉碎部位外部的位置处施加接地参考，其中所述液体EHD的至少一部分粉碎以形成具有大致一致的流量的喷雾器及其装置。
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公开(公告)号：USD390485S
公开(公告)日：1998-02-10
申请号：US60781
申请日：1996-10-07
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公开(公告)号：US4634917A
公开(公告)日：1987-01-06
申请号：US686124
申请日：1984-12-26
CPC分类号： G06F3/0414 , G01B7/004 , G01L1/16 , G01L5/228 , H01L41/1132 , A61F2002/7635 , Y10S310/80
摘要： A tactile sensing apparatus having a piezoelectric energizing layer with a plurality of conductors disposed on one surface of a piezoelectric material and a plurality of conductors disposed on the opposite surface of the piezoelectric material, the plurality of conductors having electrical connections connected to electrical energizing means. An electrical insulating layer disposed adjacent the piezoelectric energizing layer. A second piezoelectric sensing layer is disposed adjacent the insulating layer, and has conducting surfaces disposed on opposite surfaces thereof. The conductors in the piezoelectric energizing layer provide N.times.M energizing areas with N+M electrical connections to the energizing layer. Further apparatus may include an oscillator, an optional amplifier and a switching means or multiplexer for the input signal.The apparatus may optionally have more than one piezoelectric energizing layer as well as more than one piezoelectric sensing layer. PVF.sub.2 is the preferred piezoelectric material. An optional base material and protective layer may be used.A method of operating the tactile sensor includes providing a variable frequency electrical signal at a frequency and amplitude adapted to energize the energizing areas. The signal is switched to the conductors to energize selected energizing areas of the energizing layer in a predetermined sequence. The signal generated in the sensing layer that varies in frequency and amplitude in response to an object in contact with the tactile sensor is processed for frequency and amplitude information to determine the characteristics of the object such as shape, force or weight.
摘要翻译： 一种具有压电激励层的触觉感测装置，其具有设置在压电材料的一个表面上的多个导体和设置在压电材料的相对表面上的多个导体，所述多个导体具有连接到电激励装置的电连接。 设置在压电激励层附近的电绝缘层。 第二压电感测层设置在绝缘层附近，并且具有设置在其相对表面上的导电表面。 压电激励层中的导体提供具有N + M电连接到激励层的N×M激励区域。 另外的装置可以包括振荡器，可选放大器以及用于输入信号的开关装置或多路复用器。 该装置可以可选地具有多于一个的压电激励层以及多于一个的压电感测层。 PVF2是优选的压电材料。 可以使用可选的基材和保护层。 操作触觉传感器的方法包括提供适于激励通电区域的频率和幅度的可变频率电信号。 信号切换到导体，以预定的顺序激励激励层的选定的激励区域。 对感测层中产生的响应于与触觉传感器接触的物体的频率和幅度变化的信号被处理以用于频率和幅度信息以确定物体的特征，例如形状，力或重量。
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公开(公告)号：US20130124103A1
公开(公告)日：2013-05-16
申请号：US13639623
申请日：2011-04-11
IPC分类号： G01T1/167
摘要： The system for measuring the radioactive concentration of a radiopharmaceutical includes a container, an interrogation region, a radiation detector, a signal capture device and microprocessor system. The interrogation region associated with the container. The radiation detector to focus detecting radiation emitted from the interrogation region. The signal capture device capable of obtaining a radiation measurement of the interrogation region. The microprocessor system in data communication with the signal capture device. The microprocessor system is capable of calculating a radioactive concentration of a radiopharmaceutical emitting radiation contained in the interrogation region from the signal capture device.
摘要翻译： 用于测量放射性药物的放射性浓度的系统包括容器，询问区域，辐射检测器，信号捕获装置和微处理器系统。 与容器关联的询问区域。 用于对来自询问区域的辐射进行聚焦的放射线检测器。 能够获得询问区域的辐射测量的信号捕获装置。 微处理器系统与信号捕获设备进行数据通信。 微处理器系统能够计算从信号捕捉装置发出的询问区域中包含的辐射放射性药物的放射性浓度。
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公开(公告)号：US08141795B2
公开(公告)日：2012-03-27
申请号：US12859867
申请日：2010-08-20
申请人： James E. Dvorsky , Beverly A. Piatt
发明人： James E. Dvorsky , Beverly A. Piatt
CPC分类号： A61M15/02 , A61M11/001 , B05B5/0255 , B05B5/0533 , B05B5/1691
摘要： A method for delivering an aerosol, especially an aromatic aerosol, comprising the steps of contacting a capillary wick, comprising an EHD comminution site, with a liquid source, whereby at least a portion of the liquid transports to the EHD comminution site; applying a voltage to the liquid within the capillary wick at a location spaced apart from the liquid source and proximate the EHD comminution site; and applying a ground reference at a location external to the EHD comminution site, wherein at least a portion of the liquid EHD comminutes to form a spray having a generally-consistent flowrate and a device therefor.
摘要翻译： 一种用于递送气溶胶，特别是芳族气溶胶的方法，包括以下步骤：使包含EHD粉碎部位的毛细管芯与液体源接触，由此至少一部分液体输送到EHD粉碎部位; 在与液体源间隔开并且靠近EHD粉碎部位的位置向毛细管芯内的液体施加电压; 以及在所述EHD粉碎部位外部的位置处施加接地参考，其中所述液体EHD的至少一部分粉碎以形成具有大致一致的流量的喷雾器及其装置。
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