公开(公告)号：US20050280185A1

公开(公告)日：2005-12-22

申请号：US11097987

申请日：2005-04-01

申请人： David Russell ,  Andres Hernandez ,  Joshua Kinsley ,  Andrew Berlin

发明人： David Russell ,  Andres Hernandez ,  Joshua Kinsley ,  Andrew Berlin

IPC分类号： B28B7/46 ,  B29C41/02 ,  B29C67/00

CPC分类号： B28B7/465 ,  B28B1/001 ,  B29C64/165 ,  B33Y10/00 ,  B33Y30/00

摘要： The invention relates to methods and apparatus for fabricating a three-dimensional object from a representation of the object stored in memory. The apparatus includes a stationary build table for receiving successive layers of a build material and at least one movable printhead disposed above the build table. The printhead deposits a binding material in a predetermined pattern on each successive layer of the build material to form the three-dimensional object.

摘要翻译： 本发明涉及从存储在存储器中的对象的表示来制造三维物体的方法和装置。 该装置包括用于接收构建材料的连续层的静止构建工作台和布置在构建工作台上方的至少一个可移动打印头。 打印头在构建材料的每个连续层上以预定图案沉积粘合材料以形成三维物体。

公开(公告)号：US07291002B2

公开(公告)日：2007-11-06

申请号：US10817159

申请日：2004-04-02

申请人： David Russell ,  Andres Hernandez ,  Joshua Kinsley ,  Andrew Berlin

发明人： David Russell ,  Andres Hernandez ,  Joshua Kinsley ,  Andrew Berlin

IPC分类号： B28B13/02

CPC分类号： B41J29/17 ,  B29C64/112 ,  B29C64/165 ,  B33Y30/00 ,  B33Y40/00 ,  B41J2/16532 ,  B41J2/16535 ,  B41J2/16552 ,  B41J2/16579 ,  B41J3/4073

摘要： The invention relates to apparatus and methods for producing three-dimensional objects and auxiliary systems used in conjunction with the aforementioned apparatus and methods. The apparatus and methods involve continuously printing radially about a circular and/or rotating build table using multiple printheads. The apparatus and methods also include optionally using multiple build tables. The auxiliary systems relate to build material supply printhead cleaning diagnostics, and monitoring operation of the apparatus.

摘要翻译： 本发明涉及与上述装置和方法结合使用的用于制造三维物体和辅助系统的装置和方法。 该设备和方法涉及使用多个打印头连续地围绕圆形和/或旋转的构建台径向地打印。 该装置和方法还包括可选地使用多个构建表。 辅助系统涉及建立材料供应打印头清洁诊断和设备的监控操作。

公开(公告)号：US20060061618A1

公开(公告)日：2006-03-23

申请号：US10999847

申请日：2004-11-30

申请人： Andres Hernandez ,  Andrew Berlin ,  Benjamin Sweet-Block ,  Joshua Kinsley ,  Dmitriy Katalichenko ,  Chris Korda ,  Walter Zengerle ,  David Russell

发明人： Andres Hernandez ,  Andrew Berlin ,  Benjamin Sweet-Block ,  Joshua Kinsley ,  Dmitriy Katalichenko ,  Chris Korda ,  Walter Zengerle ,  David Russell

IPC分类号： B41J2/165

CPC分类号： B41J2/16552 ,  B29C64/112 ,  B33Y40/00 ,  B41J2/16532 ,  B41J2/16538

摘要： The invention relates to apparatus and methods for producing three-dimensional objects and auxiliary systems used in conjunction with the aforementioned apparatus and methods. The apparatus and methods involve 3D printing and servicing of the equipment used in the associated 3D printer.

摘要翻译： 本发明涉及与上述装置和方法结合使用的用于制造三维物体和辅助系统的装置和方法。 该设备和方法涉及3D相关3D打印机中使用的设备的3D打印和维修。

公开(公告)号：US20060061613A1

公开(公告)日：2006-03-23

申请号：US11000100

申请日：2004-11-30

申请人： William Fienup ,  Andrew Berlin ,  Andres Hernandez ,  Joshua Kinsley ,  Walter Zengerle

发明人： William Fienup ,  Andrew Berlin ,  Andres Hernandez ,  Joshua Kinsley ,  Walter Zengerle

IPC分类号： B41J29/393

CPC分类号： B41J29/393 ,  B29C64/112 ,  B33Y40/00 ,  B41J2/16532 ,  B41J2/16538 ,  B41J2/16552 ,  B41J2/1752 ,  B41J3/4073 ,  H04N1/6033

摘要： The invention relates to apparatus and methods for producing three-dimensional objects and auxiliary systems used in conjunction with the aforementioned apparatus and methods. The apparatus and methods involve 3D printing and servicing of the equipment used in the associated 3D printer.

公开(公告)号：US20060141145A1

公开(公告)日：2006-06-29

申请号：US11335282

申请日：2006-01-19

申请人： Thomas Davidson ,  Robert Phillips ,  Andres Hernandes ,  David Russell ,  Kevin Roche ,  Walter Zengerle ,  Andrew Berlin ,  Joshua Kinsley ,  Benjamin Sweet-Block ,  Darul Kisai

发明人： Thomas Davidson ,  Robert Phillips ,  Andres Hernandes ,  David Russell ,  Kevin Roche ,  Walter Zengerle ,  Andrew Berlin ,  Joshua Kinsley ,  Benjamin Sweet-Block ,  Darul Kisai

IPC分类号： B05D1/36

CPC分类号： B41J2/16552 ,  B29C41/12 ,  B29C64/165 ,  B29C64/35 ,  B29K2995/0021 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  B41J2/01 ,  B41J2/16523 ,  B41J2/16535 ,  B41J2/16541

摘要： A three-dimensional printer uses inkjet-type printheads to rapidly prototype, or print, a three-dimensional model. A powder feeder includes a conveyor system and a metering system to deliver powder to a build area in measured quantities. The powder feeder also includes a vacuum system for loading powder into a feed reservoir or chamber. The vacuum system can also be used to cleanup excess powder. Other powder control features include powder gutters and magnetic powder plows. During printing, a cleaning system operates to remove powder from the printheads. In the event of a printhead or jet failure, the failure can be detected and corrective measures taken automatically. After printing, the model can be depowdered and infiltrated in an enclosure.

公开(公告)号：US20080042321A1

公开(公告)日：2008-02-21

申请号：US11860087

申请日：2007-09-24

申请人： David Russell ,  Andres Hernandez ,  Joshua Kingsley ,  Andrew Berlin

发明人： David Russell ,  Andres Hernandez ,  Joshua Kingsley ,  Andrew Berlin

IPC分类号： B28B1/14 ,  B08B5/00

CPC分类号： B41J29/17 ,  B29C64/112 ,  B29C64/165 ,  B33Y30/00 ,  B33Y40/00 ,  B41J2/16532 ,  B41J2/16535 ,  B41J2/16552 ,  B41J2/16579 ,  B41J3/4073

摘要： The invention relates to apparatus and methods for producing three-dimensional objects and auxiliary systems used in conjunction with the aforementioned apparatus and methods. The apparatus and methods involve continuously printing radially about a circular and/or rotating build table using multiple printheads. The apparatus and methods also include optionally using multiple build tables. The auxiliary systems relate to build material supply, printhead cleaning, diagnostics, and monitoring operation of the apparatus.

摘要翻译： 本发明涉及与上述装置和方法结合使用的用于制造三维物体和辅助系统的装置和方法。 该设备和方法涉及使用多个打印头连续地围绕圆形和/或旋转的构建台径向地打印。 该装置和方法还包括可选地使用多个构建表。 辅助系统涉及建立材料供应，打印头清洁，诊断和设备的监控操作。

公开(公告)号：US07776547B2

公开(公告)日：2010-08-17

申请号：US11027470

申请日：2004-12-30

申请人： Mark Roth ,  Andrew Berlin ,  Selena Chan ,  Tae-Woong Koo ,  Xing Su ,  Lei Sun

发明人： Mark Roth ,  Andrew Berlin ,  Selena Chan ,  Tae-Woong Koo ,  Xing Su ,  Lei Sun

IPC分类号： G01N33/53

CPC分类号： G01N33/54366 ,  G01N33/54373 ,  G01N33/58 ,  Y10T436/10

摘要： Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.

摘要翻译： 提供了用于使用用复合有机 - 无机纳米颗粒（COIN）标记的探针和嵌入探针部分所连接的聚合物基质内的COIN的微球来测定可能为活细胞的细胞样品的方法和装置。 COIN在激光照射下固有地产生SERS信号，使得COIN标记的探针特别适用于多种测定细胞的方法，包括可能包含在细胞内或细胞内的生物分子，其中大部分不是固有的拉曼活性的。 本发明提供使用特异性和简并结合的夹心免疫测定的变体，组织样品和细胞微结构的反相测定方法，溶液置换和竞争测定等。 还提供了用于实施本发明测定的系统和芯片。

公开(公告)号：US20100151136A1

公开(公告)日：2010-06-17

申请号：US12710594

申请日：2010-02-23

申请人： Thomas Davidson ,  Robert A. Philips ,  Andres T. Hernandes ,  David B. Russell ,  Kevin Roche ,  Walter H. Zengerle, III ,  Andrew Berlin ,  Joshua P. Kinsley ,  Benjamin Daniel Sweet-Block ,  Darul Kisai

发明人： Thomas Davidson ,  Robert A. Philips ,  Andres T. Hernandes ,  David B. Russell ,  Kevin Roche ,  Walter H. Zengerle, III ,  Andrew Berlin ,  Joshua P. Kinsley ,  Benjamin Daniel Sweet-Block ,  Darul Kisai

IPC分类号： B05D3/12

CPC分类号： B29C41/36 ,  B22F3/008 ,  B29C41/12 ,  B29C64/165 ,  B29K2995/0021 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  B41J2/155 ,  B41J2/16541 ,  B41J2/16552 ,  B41J2/17513 ,  B41J2/17556 ,  B41J2/17596 ,  B41J2002/14475 ,  B41J2202/20

摘要： A three-dimensional printer uses inkjet-type printheads to rapidly prototype, or print, a three-dimensional model. A powder feeder includes a conveyor system and a metering system to deliver powder to a build area in measured quantities. The powder feeder also includes a vacuum system for loading powder into a feed reservoir or chamber. The vacuum system can also be used to cleanup excess powder. Other powder control features include powder gutters and magnetic powder plows. During printing, a cleaning system operates to remove powder from the printheads. In the event of a printhead or jet failure, the failure can be detected and corrective measures taken automatically. After printing, the model can be depowdered and infiltrated in an enclosure.

摘要翻译： 三维打印机使用喷墨式打印头来快速原型化或打印三维模型。 粉末进料器包括输送机系统和计量系统，以测量的量将粉末输送到建筑面积。 粉末进料器还包括用于将粉末装载到进料储存器或室中的真空系统。 真空系统也可用于清理多余的粉末。 其他粉末控制功能包括粉末槽和磁粉犁。 在打印期间，清洁系统操作以从打印头中去除粉末。 在打印头或喷射器故障的情况下，可以检测到故障并自动采取纠正措施。 打印后，模型可以被去除并渗透到外壳中。

公开(公告)号：US07709247B2

公开(公告)日：2010-05-04

申请号：US10911441

申请日：2004-08-04

申请人： Tae-Woong Koo ,  Andrew Berlin ,  Ken Salsman ,  Brian Ostrovsky

发明人： Tae-Woong Koo ,  Andrew Berlin ,  Ken Salsman ,  Brian Ostrovsky

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： G01N21/65 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00639 ,  B01J2219/00722 ,  B01L3/5027 ,  C12Q1/6825 ,  G01N21/3581 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2021/651 ,  C12Q2545/114 ,  C12Q2523/313

摘要： Provided herein are methods and systems for detecting biomolecular binding events using gigahertz or terahertz radiation. The methods and systems use low-energy spectroscopy to detect biomolecular binding events between molecules in an aqueous solution. The detected biomolecular binding events include, for example, nucleic acid hybridizations, antibody/antigen binding, and receptor/ligand binding.

摘要翻译： 本文提供了使用千兆兹或太赫兹辐射检测生物分子结合事件的方法和系统。 该方法和系统使用低能谱来检测水溶液中分子之间的生物分子结合事件。 检测到的生物分子结合事件包括例如核酸杂交，抗体/抗原结合和受体/配体结合。

公开(公告)号：US20090011066A1

公开(公告)日：2009-01-08

申请号：US12192412

申请日：2008-08-15

申请人： Thomas Davidson ,  Robert A. Phillips ,  Andres T. Hernandez ,  David B. Russell ,  Kevin Roche ,  Walter H. Zengerle, III ,  Andrew Berlin ,  Joshua P. Kinsley ,  Benjamin Daniel Sweet-Block ,  Darul Kisai

发明人： Thomas Davidson ,  Robert A. Phillips ,  Andres T. Hernandez ,  David B. Russell ,  Kevin Roche ,  Walter H. Zengerle, III ,  Andrew Berlin ,  Joshua P. Kinsley ,  Benjamin Daniel Sweet-Block ,  Darul Kisai

IPC分类号： B29C67/00

CPC分类号： B29C41/36 ,  B22F3/008 ,  B29C41/12 ,  B29C64/165 ,  B29K2995/0021 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  B41J2/155 ,  B41J2/16541 ,  B41J2/16552 ,  B41J2/17513 ,  B41J2/17556 ,  B41J2/17596 ,  B41J2002/14475 ,  B41J2202/20

摘要： A three-dimensional printer uses inkjet-type printheads to rapidly prototype, or print, a three-dimensional model. A powder feeder includes a conveyor system and a metering system to deliver powder to a build area in measured quantities. The powder feeder also includes a vacuum system for loading powder into a feed reservoir or chamber. The vacuum system can also be used to cleanup excess powder. Other powder control features include powder gutters and magnetic powder plows. During printing, a cleaning system operates to remove powder from the printheads. In the event of a printhead or jet failure, the failure can be detected and corrective measures taken automatically. After printing, the model can be depowdered and infiltrated in an enclosure.

摘要翻译： 三维打印机使用喷墨式打印头来快速原型化或打印三维模型。 粉末进料器包括输送机系统和计量系统，以测量的量将粉末输送到建筑面积。 粉末进料器还包括用于将粉末装载到进料储存器或室中的真空系统。 真空系统也可用于清理多余的粉末。 其他粉末控制功能包括粉末槽和磁粉犁。 在打印期间，清洁系统操作以从打印头中去除粉末。 在打印头或喷射器故障的情况下，可以检测到故障并自动采取纠正措施。 打印后，模型可以被去除并渗透到外壳中。