公开(公告)号：US20070060858A1

公开(公告)日：2007-03-15

申请号：US11207249

申请日：2005-08-19

申请人： David Sogard ,  Leonard Richardson ,  Kent Harrison ,  Diane Sheahen

发明人： David Sogard ,  Leonard Richardson ,  Kent Harrison ,  Diane Sheahen

IPC分类号： A61M5/00

CPC分类号： A61B17/0057 ,  A61B17/00234 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/00004 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00867 ,  A61B2017/0404 ,  A61B2017/0443 ,  A61B2017/06171 ,  A61B2017/0647 ,  A61B2017/3488

摘要： Methods, apparatus, and systems for occluding a multiplicity of parallel membranes, such as found in a patent foramen ovale (PFO). Methods, apparatus, and systems include the use of a positioning device that can be seated on the limbus of the septum secundum (SS). The positioning device includes a piercing member that can pierce the SS and septum primum (SP). The positioning device also includes a fastening member that can engage the SS and SP to fasten the tissues and thereby occlude a PFO.

摘要翻译： 闭塞多个平行膜的方法，装置和系统，例如在卵孔专利（PFO）中发现的。 方法，装置和系统包括使用可以坐在隔膜（SS）的角膜缘上的定位装置。 定位装置包括能够穿透SS和隔膜（SP）的穿刺构件。 定位装置还包括紧固构件，其可以接合SS和SP以紧固组织，从而封闭PFO。

公开(公告)号：US20070043318A1

公开(公告)日：2007-02-22

申请号：US11207317

申请日：2005-08-19

申请人： David Sogard ,  Leonard Richardson ,  Kent Harrison ,  Diane Sheahen

发明人： David Sogard ,  Leonard Richardson ,  Kent Harrison ,  Diane Sheahen

IPC分类号： A61B17/20

CPC分类号： A61B17/0057 ,  A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/3488

摘要： Methods, apparatus, and systems for locating a patent foramen ovale (PFO) with a positioning device that can be configured to occlude the PFO. Methods, apparatus, and systems include the use of a positioning device that can be seated on the limbus of a septum secundum (SS). The positioning device includes a piercing member that can pierce the SS and a septum primum.

摘要翻译： 用于定位具有定位装置的专利孔卵孔（PFO）的方法，装置和系统，所述定位装置可被配置为闭塞PFO。 方法，装置和系统包括使用可以坐在隔膜（SS）的角膜缘上的定位装置。 该定位装置包括能刺穿SS和穿孔的刺穿构件。

公开(公告)号：US20070173930A1

公开(公告)日：2007-07-26

申请号：US11337162

申请日：2006-01-20

申请人： David Sogard ,  Kent Harrison ,  Leonard Richardson

发明人： David Sogard ,  Kent Harrison ,  Leonard Richardson

IPC分类号： A61F2/24

CPC分类号： A61B17/00234 ,  A61B17/0469 ,  A61B17/0482 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0472 ,  A61B2017/06057 ,  A61F2/2445 ,  A61F2/2457

摘要： Methods, apparatus, and systems for altering the configuration of a heart valve. Methods, apparatus, and systems include the use of a cord delivered into the heart by a delivery catheter that can be manipulated by a receiving catheter so as to improve the heart valve function.

摘要翻译： 用于改变心脏瓣膜构造的方法，装置和系统。 方法，装置和系统包括通过可由接收导管操纵的输送导管输送到心脏中的绳索的用途，以便改善心脏瓣膜功能。

公开(公告)号：US20100269838A1

公开(公告)日：2010-10-28

申请号：US12765369

申请日：2010-04-22

申请人： Aiden Flanagan ,  Kent Harrison ,  Liliana Atanasoska ,  David Sogard ,  Liza Davis

发明人： Aiden Flanagan ,  Kent Harrison ,  Liliana Atanasoska ,  David Sogard ,  Liza Davis

IPC分类号： A61B19/00

CPC分类号： A61K9/0009 ,  A61K9/1676 ,  A61K9/501 ,  A61K9/5094 ,  A61K9/5115

摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.

摘要翻译： 提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。 磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。 根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置 ，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。 治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

公开(公告)号：US20100132718A1

公开(公告)日：2010-06-03

申请号：US12555891

申请日：2009-09-09

申请人： Aaron Khieu ,  Daniel James Horn ,  Anthony C. Vrba ,  John Blix ,  Kent Harrison ,  Timothy J. Ley

发明人： Aaron Khieu ,  Daniel James Horn ,  Anthony C. Vrba ,  John Blix ,  Kent Harrison ,  Timothy J. Ley

IPC分类号： A61F6/06 ,  A61F2/04

CPC分类号： A61B17/12022 ,  A61B17/12 ,  A61B17/12109 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00867 ,  A61F6/00 ,  A61F6/20 ,  A61F6/22 ,  A61F6/225

摘要： A device for occluding a target body lumen, comprises a wire structure defining a wire structure lumen extending therethrough and movable between a reduced diameter insertion configuration and an expanded diameter deployed configuration and a basket structure extending across the wire structure lumen and including therein a cell growth promoting agent to promote cell growth across the wire structure lumen to occlude the target body lumen.

摘要翻译： 用于闭塞目标体腔的装置包括线结构，其限定延伸穿过其中的线结构内腔，并且可以在直径较小的插入构型和扩展直径展开构型之间移动，并且可延伸穿过线结构腔并且在其中包括细胞生长 促进剂以促进穿过线结构腔的细胞生长以封闭目标体腔。

公开(公告)号：US20050256450A1

公开(公告)日：2005-11-17

申请号：US11185801

申请日：2005-07-21

申请人： Maria Palasis ,  James Barry ,  Louis Ellis ,  Gary Hendrickson ,  Kent Harrison ,  Lixiao Wang

发明人： Maria Palasis ,  James Barry ,  Louis Ellis ,  Gary Hendrickson ,  Kent Harrison ,  Lixiao Wang

IPC分类号： A61B17/00 ,  A61B17/32 ,  A61B17/34 ,  A61B19/00 ,  A61F2/02 ,  A61L29/16 ,  A61M25/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61B17/3468 ,  A61B17/3478 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/320084 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61F2/2493 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/64 ,  A61M25/0084 ,  A61M37/0069 ,  A61M2025/0004 ,  A61M2025/0089

摘要： A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.

摘要翻译： 提供了用于放置原位植入物的导管。 该导管可以包括具有近端和远端的第一细长轴，具有近端和远端的第二细长轴，设置在第一轴的远端处的第一尖锐的远侧末端和第二尖锐远端 设置在第二轴的远端。 根据本发明，第一轴和第二轴也可以在第一轴的远端处彼此固定。 此外，根据其他教导，第一锐化的远侧末端可以在实践本发明的导管中延伸超过第二锋利的远侧末端。

公开(公告)号：US07485109B2

公开(公告)日：2009-02-03

申请号：US11357558

申请日：2006-02-17

申请人： Martin Willard ,  Kent Harrison

发明人： Martin Willard ,  Kent Harrison

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

摘要： Devices and methods to cool a target tissue region inside the body are described. Fluid cooled below normal body temperature and blood at a normal body temperature are provided to the tissue region in proportions to cool the tissue region. A system for controlling the temperature of the target tissue region is disclosed. The system includes a catheter and a control system that controls the amount of cool fluid and blood provided to the tissue region. A catheter for providing cool fluid to the tissue region is also provided. The catheter includes a temperature sensor that extends to a location distal to the distal end of the catheter to sense the temperature of the tissue region.

摘要翻译： 描述了用于冷却身体内的目标组织区域的装置和方法。 在正常体温下冷却的流体和在正常体温下的血液按比例提供给组织区域以冷却组织区域。 公开了一种用于控制目标组织区域的温度的系统。 该系统包括导管和控制系统，其控制提供给组织区域的冷流体和血液的量。 还提供了用于向组织区域提供冷流体的导管。 导管包括温度传感器，其延伸到远离导管远端的位置以感测组织区域的温度。

公开(公告)号：US20060142827A1

公开(公告)日：2006-06-29

申请号：US11357558

申请日：2006-02-17

申请人： Martin Willard ,  Kent Harrison

发明人： Martin Willard ,  Kent Harrison

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

摘要： Devices and methods to cool a target tissue region inside the body are described. Fluid cooled below normal body temperature and blood at a normal body temperature are provided to the tissue region in proportions to cool the tissue region. A system for controlling the temperature of the target tissue region is disclosed. The system includes a catheter and a control system that controls the amount of cool fluid and blood provided to the tissue region. A catheter for providing cool fluid to the tissue region is also provided. The catheter includes a temperature sensor that extends to a location distal to the distal end of the catheter to sense the temperature of the tissue region.

公开(公告)号：US09320525B2

公开(公告)日：2016-04-26

申请号：US12555891

申请日：2009-09-09

申请人： Aaron Khieu ,  Daniel James Horn ,  Anthony C. Vrba ,  John Blix ,  Kent Harrison ,  Timothy J. Ley

发明人： Aaron Khieu ,  Daniel James Horn ,  Anthony C. Vrba ,  John Blix ,  Kent Harrison ,  Timothy J. Ley

IPC分类号： A61F6/20 ,  A61B17/12 ,  A61F6/22 ,  A61F6/00 ,  A61B17/00

CPC分类号： A61B17/12022 ,  A61B17/12 ,  A61B17/12109 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00867 ,  A61F6/00 ,  A61F6/20 ,  A61F6/22 ,  A61F6/225

摘要： A device for occluding a target body lumen, comprises a wire structure defining a wire structure lumen extending therethrough and movable between a reduced diameter insertion configuration and an expanded diameter deployed configuration and a basket structure extending across the wire structure lumen and including therein a cell growth promoting agent to promote cell growth across the wire structure lumen to occlude the target body lumen.

摘要翻译： 用于闭塞目标体腔的装置包括线结构，其限定延伸穿过其中的线结构内腔，并且可以在直径较小的插入构型和扩展直径展开构型之间移动，并且可延伸穿过线结构腔并且在其中包括细胞生长 促进剂以促进穿过线结构腔的细胞生长以封闭目标体腔。

公开(公告)号：US20060142826A1

公开(公告)日：2006-06-29

申请号：US11356481

申请日：2006-02-17

申请人： Martin Willard ,  Kent Harrison

发明人： Martin Willard ,  Kent Harrison

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

摘要： Devices and methods to cool a target tissue region inside the body are described. Fluid cooled below normal body temperature and blood at a normal body temperature are provided to the tissue region in proportions to cool the tissue region. A system for controlling the temperature of the target tissue region is disclosed. The system includes a catheter and a control system that controls the amount of cool fluid and blood provided to the tissue region. A catheter for providing cool fluid to the tissue region is also provided. The catheter includes a temperature sensor that extends to a location distal to the distal end of the catheter to sense the temperature of the tissue region.