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1.发明授权Arylmethylenyl derivatives of imidazolidinones useful as antiinflammatory agents 失效可用作抗炎剂的咪唑啉酮的芳基甲基衍生物
公开(公告)号：US5464856A
公开(公告)日：1995-11-07
申请号：US185748
申请日：1994-01-24
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明涉及选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性。
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2.发明授权N-substituted-2-hydroxy-.alpha.-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade 失效N-取代-2-羟基-α-氧代苯乙酰胺和具有作为花生四烯酸级联的调节剂的活性的药物组合物
公开(公告)号：US4939133A
公开(公告)日：1990-07-03
申请号：US782763
申请日：1985-10-01
申请人： David T. Connor , Daniel L. Flynn , Wiaczeslaw A. Cetenko , Jagadish C. Sircar , Charles F. Schwender , Elizabeth A. Johnson , Roderick J. Sorenson , Paul C. Unangst
发明人： David T. Connor , Daniel L. Flynn , Wiaczeslaw A. Cetenko , Jagadish C. Sircar , Charles F. Schwender , Elizabeth A. Johnson , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： C12N9/99 , A61K31/165 , A61K31/215 , A61K31/24 , A61K31/27 , A61P9/00 , A61P11/00 , A61P25/04 , A61P29/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C67/00 , C07C225/22 , C07C227/00 , C07C229/42 , C07C229/44 , C07C231/02 , C07C233/12 , C07C235/64 , C07C235/72 , C07C301/00 , C07C303/40 , C07C311/00 , C07C313/00 , C07C315/04 , C07C317/46 , C07C317/48 , C07C323/12
CPC分类号： A61K31/165 , C07C233/12
摘要： The present invention relates to novel N-substituted 2-hydroxybenzamide and N-substituted 2-hydroxy-.alpha.-oxo-benezene acetamide compounds pharmaceutical compositions, and methods of use for therefore for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.
摘要翻译： 本发明涉及新型N-取代的2-羟基苯甲酰胺和N-取代的2-羟基-α-氧代 - 乙烯乙酰胺化合物药物组合物，以及用于治疗其中具有脂氧合酶活性的产物有助于 病理状况。 选择的新型中间体也是本发明。
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3.发明授权Enolamides, pharmaceutical compositions and methods of use thereof for treating inflammation 失效烯酰胺，药物组合物及其用于治疗炎症的方法
公开(公告)号：US4921871A
公开(公告)日：1990-05-01
申请号：US121264
申请日：1987-11-16
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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4.发明授权Benzofurans and benzothiophenes having antiallergic activity and method of use thereof 失效具有抗过敏活性的苯并呋喃和苯并噻吩及其使用方法
公开(公告)号：US4910317A
公开(公告)日：1990-03-20
申请号：US210206
申请日：1988-06-27
IPC分类号： C07D307/85 , C07D333/70 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , C07D307/85 , C07D333/70 , C07D409/12
摘要： Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome. The benzothiophenes of the present invention are particularly 2-tetrazolylcarboxamides of the benzothiophenes.
摘要翻译： 具有抗过敏活性的新型苯并噻吩和具有治疗急性呼吸窘迫综合征的活性的新型和其它选择的苯并噻吩类。 本发明的苯并噻吩特别是苯并噻吩的2-四唑基甲酰胺。
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5.发明授权Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade 失效新颖的烯醇酰胺，药物组合物及其用于花生四烯酸级联调节剂的活性的方法
公开(公告)号：US4874758A
公开(公告)日：1989-10-17
申请号：US164355
申请日：1988-03-04
申请人： Mary E. Carethers , Wiaczeslaw A. Centenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Centenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and method of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗脂氧合酶活性产物或白三烯的作用对病理状况的作用。
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公开(公告)号：US4332947A
公开(公告)日：1982-06-01
申请号：US230167
申请日：1981-01-30
申请人： Francis J. Tinney , David T. Connor , Wiaczeslaw A. Cetenko , Joseph J. Kerbleski , Roderick J. Sorenson
发明人： Francis J. Tinney , David T. Connor , Wiaczeslaw A. Cetenko , Joseph J. Kerbleski , Roderick J. Sorenson
IPC分类号： C07D333/38 , C07D495/14 , C07D409/02 , C07D409/14
CPC分类号： C07D495/14 , C07D333/38
摘要： Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.
摘要翻译： 公开了氧 - 吡啶并[1,2-a]噻吩并嘧啶化合物，其盐，生产方法，其制备中间体，含有所述化合物的药物组合物和使用所述组合物治疗过敏症的方法。
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7.发明授权Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents 失效已知和选择的可用作抗过敏剂和抗炎剂的噻唑烷酮，咪唑烷酮和恶唑烷酮的新型芳基亚甲基衍生物
公开(公告)号：US5208250A
公开(公告)日：1993-05-04
申请号：US702132
申请日：1991-05-13
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明涉及选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性。
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公开(公告)号：US4868205A
公开(公告)日：1989-09-19
申请号：US167272
申请日：1988-03-11
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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公开(公告)号：US4868199A
公开(公告)日：1989-09-19
申请号：US167264
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04 , C07D491/048
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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10.发明授权
公开(公告)号：US4761424A
公开(公告)日：1988-08-02
申请号：US782623
申请日：1985-10-01
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D491/048 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/54 , A61P9/00 , A61P11/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/12 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/68 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/60 , C07D333/64 , C07D333/68 , C07D333/70 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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