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公开(公告)号：US07241879B2
公开(公告)日：2007-07-10
申请号：US10899715
申请日：2004-07-26
申请人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
发明人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC分类号： C07H21/04
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
摘要： HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
摘要翻译： 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。
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2.发明授权公开(公告)号：US06797809B2
公开(公告)日：2004-09-28
申请号：US10637323
申请日：2003-08-08
申请人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
发明人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC分类号： C07K1700
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
摘要： HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
摘要翻译： 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。
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公开(公告)号：US06632601B2
公开(公告)日：2003-10-14
申请号：US09881654
申请日：2001-06-14
申请人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
发明人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC分类号： C12Q170
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
摘要： HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
摘要翻译： 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。
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公开(公告)号：US06630298B2
公开(公告)日：2003-10-07
申请号：US09881239
申请日：2001-06-14
申请人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
发明人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC分类号： C12Q170
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
摘要： An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.
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公开(公告)号：US06261764B1
公开(公告)日：2001-07-17
申请号：US09158815
申请日：1998-09-22
IPC分类号： C12Q170
CPC分类号： G01N33/5767 , G01N33/5306 , G01N33/54306 , G01N33/6854 , G01N2469/20 , Y10T436/108331 , Y10T436/2525
摘要： The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.
摘要翻译： 本发明涉及用于抗原的抗原稀释剂或缓冲剂，特别是包含还原剂的HCV重组抗原。 抗原稀释液或缓冲液用作抗原的稳定缓冲液。 本发明还涉及用于自动化免疫测定中的抗原稀释剂或缓冲液。
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6.发明授权Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay 有权编码用于HCV抗原/抗体组合测定中的多表位融合抗原的多核苷酸公开(公告)号：US07319144B2
公开(公告)日：2008-01-15
申请号：US10643853
申请日：2003-08-19
申请人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
发明人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC分类号： C07H21/00 , C12N15/00 , C12N15/09 , C12N15/33 , C12N15/51 , C12P21/00 , A61K39/00 , A61K39/29
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
摘要： The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope fusion antigen, that can detect both HCV antigens and antibodies present in a sample. The invention also includes polynucleotides encoding multiple epitope fusion antigens for use in the assay, recombinant vectors and host cells comprising such polynucleotides, and methods of producing the multiple epitope fusion antigens.
摘要翻译： 本发明涉及检测生物样品中HCV感染的方法，所述方法包括提供包含HCV抗核心抗体，包含HCV NS3 / 4a表位的抗原和HCV多表位融合抗原的免疫测定固体支持物， 其可以检测样品中存在的HCV抗原和抗体。 本发明还包括编码用于测定的多种表位融合抗原的多核苷酸，包含此类多核苷酸的重组载体和宿主细胞，以及产生多表位融合抗原的方法。
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公开(公告)号：US06537745B2
公开(公告)日：2003-03-25
申请号：US09775962
申请日：2001-02-02
IPC分类号： C12Q170
CPC分类号： G01N33/5767 , G01N33/5306 , G01N33/54306 , G01N33/6854 , G01N2469/20 , Y10T436/108331 , Y10T436/2525
摘要： The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.
摘要翻译： 本发明涉及用于抗原的抗原稀释剂或缓冲剂，特别是包含还原剂的HCV重组抗原。 抗原稀释液或缓冲液用作抗原的稳定缓冲液。 本发明还涉及用于自动化免疫测定中的抗原稀释剂或缓冲液。
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公开(公告)号：US06815160B1
公开(公告)日：2004-11-09
申请号：US10048191
申请日：2002-01-25
申请人： David Y. Chien , Phillip Arcangel
发明人： David Y. Chien , Phillip Arcangel
IPC分类号： C12Q170
CPC分类号： G01N33/5767 , C07K16/109 , G01N2333/18
摘要： Imnunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided.
摘要翻译： 提供检测丙型肝炎病毒蛋白和丙型肝炎病毒蛋白与生物样品抗体之间的免疫复合物的免疫测定方法，筛选丙型肝炎病毒血液制品的方法及其使用的试剂盒。
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公开(公告)号：US06391540B1
公开(公告)日：2002-05-21
申请号：US09158301
申请日：1998-09-22
IPC分类号： C12Q170
CPC分类号： G01N33/5767 , G01N33/5306 , G01N33/54306 , G01N33/6854 , G01N2469/20 , Y10S436/82
摘要： The present invention is directed to assays for detecting antibodies in a sample in a single incubation step. The assays employ universal solid phases and/or universal detectable markers, and facilitate the detection and differentiation of antigens from the same source or from different sources in a single test sample. The present invention includes test kits for performing the methods according to the invention.
摘要翻译： 本发明涉及用于在单个孵育步骤中检测样品中的抗体的测定法。 测定采用通用固相和/或通用可检测标记，并促进在单个测试样品中来自相同来源或不同来源的抗原的检测和分化。 本发明包括用于执行根据本发明的方法的测试试剂盒。
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公开(公告)号：US07166426B2
公开(公告)日：2007-01-23
申请号：US10658782
申请日：2003-09-08
申请人： Phillip Arcangel , David Chien
发明人： Phillip Arcangel , David Chien
CPC分类号： G01N33/5767
摘要： An HCV antigen/antibody/antigen assay is provided. The assay employs an isolated first antigen from a region of the HCV polyprotein, and an HCV multiple epitope fusion antigen that includes an epitope from the same region of the polyprotein as the first antigen. Both the first antigen and the multiple epitope fusion antigen bind antibodies present in an HCV-infected sample.
摘要翻译： 提供HCV抗原/抗体/抗原测定。 该测定采用来自HCV多蛋白的区域的分离的第一抗原和包含与第一抗原的多蛋白相同区域的表位的HCV多表位融合抗原。 第一抗原和多表位融合抗原都结合HCV感染样品中存在的抗体。
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