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    Compositions and methods for treating joints
    1.
    发明授权
    Compositions and methods for treating joints 有权

    公开(公告)号：US11090328B2

    公开(公告)日：2021-08-17

    申请号：US16030955

    申请日：2018-07-10

    申请人： DePuy Mitek, LLC

    发明人： Julia Hwang ,  Dongling Su ,  Julius Lopez

    IPC分类号： A61K31/728 ,  A61K31/737 ,  A61M5/19 ,  A61M5/20 ,  A61K9/00 ,  A61K31/7008

    摘要： Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluronic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”).

    COMPOSITIONS AND METHODS FOR STABILIZED POLYSACCHARIDE FORMULATIONS
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR STABILIZED POLYSACCHARIDE FORMULATIONS 审中-公开
    稳定多糖制剂的组合物和方法

    公开(公告)号：US20140088038A1

    公开(公告)日：2014-03-27

    申请号：US14090599

    申请日：2013-11-26

    申请人： DePuy Mitek, LLC

    发明人： Dongling Su ,  Julia Hwang ,  Brooks J. Story

    IPC分类号： A61K47/26 ,  A61K47/02 ,  A61K47/10 ,  A61K31/728 ,  A61K31/737

    CPC分类号： A61K47/26 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/726 ,  A61K31/728 ,  A61K31/737 ,  A61K47/02 ,  A61K47/10 ,  A61L27/20 ,  A61L27/505 ,  A61K2300/00 ,  C08L5/08

    摘要： Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluronic acid (“HA”), in combination with at least one stabilizer. The composition can include a stabilizer that increases the stability and shelf-life of the HA. In another embodiment, the compositions and methods can also include an additional component, such as one or more glycosaminoglycans (“GAG”) or GAG precursors. Examples of GAGs or GAG precursors can include chondroitin sulfate (“CS”), dermatan sulfate, heparin, heparan sulfate, keratan sulfate, and glucosamine (“GlcN”).

    摘要翻译： 提供组合物和方法用于治疗关节病，例如骨关节炎和/或与之相关的疼痛。 组合物和方法利用第一组分，即透明质酸（“HA”）与至少一种稳定剂的组合。 组合物可以包括增加HA的稳定性和保质期的稳定剂。 在另一个实施方案中，组合物和方法还可以包括另外的组分，例如一种或多种糖胺聚糖（“GAG”）或GAG前体。 GAG或GAG前体的实例可以包括硫酸软骨素（“CS”），硫酸皮肤素，肝素，硫酸乙酰肝素，硫酸角质素和葡糖胺（“GlcN”）。

    COMPOSITIONS AND METHODS FOR TREATING JOINTS
    5.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING JOINTS 有权
    组合物和处理接头的方法

    公开(公告)号：US20130172255A1

    公开(公告)日：2013-07-04

    申请号：US13788838

    申请日：2013-03-07

    申请人： DePuy Mitek, LLC

    发明人： Ben Byers ,  Dongling Su ,  Julia Hwang

    IPC分类号： A61K38/18 ,  A61K9/00 ,  A61M5/19 ,  A61K31/728

    CPC分类号： A61K38/1875 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/728 ,  A61K38/18 ,  A61M5/19 ,  A61M5/284 ,  A61M5/31 ,  A61M39/223 ,  A61K2300/00

    摘要： Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.

    摘要翻译： 公开了用于治疗骨关节炎的关节内注射的方法和组合物。 包括透明质酸和骨形态发生蛋白（如rhGDF-5）的组合的方法和组合物可用于任何滑膜关节，包括膝盖，肩部，髋，踝，踝关节，手，脊柱小面或颞下颌关节， 缓解疼痛和减缓疾病进展。

    COMPOSITIONS AND METHODS FOR TREATING JOINTS
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING JOINTS 审中-公开
    组合物和处理接头的方法

    公开(公告)号：US20130178827A1

    公开(公告)日：2013-07-11

    申请号：US13750148

    申请日：2013-01-25

    申请人： DEPUY MITEK, LLC

    发明人： Julia Hwang ,  Dongling Su ,  Julius Lopez

    IPC分类号： A61M5/19

    CPC分类号： A61K31/728 ,  A61K9/0019 ,  A61K31/7008 ,  A61K31/737 ,  A61M5/19 ,  A61M5/2066 ,  A61K2300/00

    摘要： Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”)

    摘要翻译： 提供组合物和方法用于治疗关节病，例如骨关节炎和/或与之相关的疼痛。 组合物和方法利用第一组分，即透明质酸（“HA”）与冻干的第二组分组合，其有效地至少暂时降低HA的粘度。 在一个示例性实施方案中，第二组分是一种或多种糖胺聚糖（“GAG”），例如硫酸软骨素（“CS”），包括CS4和/或CS6，硫酸皮肤素，肝素，硫酸乙酰肝素和硫酸角质素。 组合物可任选地包括其它联合补充剂，例如葡糖胺（“GlcN”）