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    Method for preparing porous shells or gels from glass particles
    1.
    发明授权
    Method for preparing porous shells or gels from glass particles 有权
    从玻璃颗粒制备多孔壳或凝胶的方法

    公开(公告)号：US06358531B1

    公开(公告)日：2002-03-19

    申请号：US09241492

    申请日：1999-02-01

    申请人： Delbert E. Day ,  Samuel D. Conzone

    发明人： Delbert E. Day ,  Samuel D. Conzone

    IPC分类号： A61K914

    CPC分类号： A61K9/501 ,  A61K9/1611 ,  C03C1/006 ,  C03C11/002 ,  C03C12/00 ,  Y10S977/775 ,  Y10S977/906

    摘要： A method is provided for preparing shells, concentric shells or porous, homogenous gels from alkali borate glass particles at low temperatures (i.e. room temperature or less than above 100° C.). The alkali borate glass particles contain one or more cations such as aluminum which react with an aqueous solution containing an anion such as hydroxide to form an aqueous insoluble material having a solubility limit of less than about 0.01 wt. percent. The resulting shells or gels may be used in many different applications such as a filler in resins, as filters, precursors for nano-sized powders, as thin surface films or catalyst support media. The resulting shells or gels may also have a chemotherapeutic drug added thereto, following which the resulting product is administered to a mammal and the insoluble material is dissolved form the product in vivo through administration of chelating agent.

    摘要翻译： 提供了一种在低温（即室温或低于100℃）下从碱金属硼酸盐玻璃颗粒制备壳，同心圆壳或多孔同质凝胶的方法。 碱金属硼酸盐玻璃颗粒含有一种或多种阳离子例如铝，其与含有阴离子如氢氧化物的水溶液反应，形成溶解度极限小于约0.01重量％的水不溶性物质。 百分。 所得的壳或凝胶可用于许多不同的应用，例如树脂中的填料，作为过滤器，用于纳米尺寸粉末的前体，作为薄表面膜或催化剂载体介质。 所得的壳或凝胶也可以具有加入其中的化学治疗药物，随后将所得产物施用于哺乳动物，并且通过施用螯合剂在体内将不溶性物质从体内溶解。

    Controlling vessel growth and directionality in mammals and implantable material
    3.
    发明授权
    Controlling vessel growth and directionality in mammals and implantable material 有权
    控制哺乳动物和可植入材料中的血管生长和方向性

    公开(公告)号：US08337875B2

    公开(公告)日：2012-12-25

    申请号：US12683211

    申请日：2010-01-06

    申请人： Steven B. Jung ,  Delbert E. Day

    发明人： Steven B. Jung ,  Delbert E. Day

    IPC分类号： A61F2/00

    CPC分类号： C03C13/00 ,  A61L27/10 ,  A61L27/58 ,  C03C4/0007 ,  C03C4/0035 ,  C03C2213/02

    摘要： A method for directing vessel growth toward a blood-deficient site in a mammal comprising implanting into the mammal an assembly of at glass fibers to form a vascular bridge with a first end of the vascular bridge in contact with the blood-deficient site and a second end of the vascular bridge remote from the blood-deficient site. Over time the bridge biodegrades and promotes vascularity in the direction of the bridge.

    摘要翻译： 一种用于将血管生长导向哺乳动物的血液缺乏部位的方法，包括向玻璃纤维植入哺乳动物组件以形成与血液缺陷部位接触的血管桥的第一端的血管桥，第二 远离血液缺乏部位的血管桥端。 随着时间的推移，桥梁在桥梁的方向上生物降解和促进血管分布。

    Sealing glasses for titanium and titanium alloys
    5.
    发明授权
    Sealing glasses for titanium and titanium alloys 失效
    钛和钛合金密封眼镜

    公开(公告)号：US5648302A

    公开(公告)日：1997-07-15

    申请号：US713294

    申请日：1996-09-13

    申请人： Richard K. Brow ,  Howard L. McCollister ,  Carol C. Phifer ,  Delbert E. Day

    发明人： Richard K. Brow ,  Howard L. McCollister ,  Carol C. Phifer ,  Delbert E. Day

    IPC分类号： C03C3/068 ,  C03C3/15 ,  C03C8/24

    CPC分类号： C03C3/068 ,  A61N1/3754 ,  C03C3/15 ,  C03C8/24

    摘要： Barium lanthanoborate sealing-glass compositions are provided comprising various combinations (in terms of mole-%) of boron oxide (B.sub.2 O.sub.3), barium oxide (BaO), lanthanum oxide (La.sub.2 O.sub.3), and at least one other oxide selected from the group consisting of aluminum oxide (Al.sub.2 O.sub.3), calcium oxide (CaO), lithium oxide (Li.sub.2 O), sodium oxide (Na.sub.2 O), silicon dioxide (SiO.sub.2), or titanium dioxide (TiO.sub.2). These sealing-glass compositions are useful for forming hermetic glass-to-metal seals with titanium and titanium alloys having an improved aqueous durability and favorable sealing characteristics. Examples of the sealing-glass compositions are provided having coefficients of thermal expansion about that of titanium or titanium alloys, and with sealing temperatures less than about 900.degree. C., and generally about 700.degree.-800.degree. C. The barium lanthanoborate sealing-glass compositions are useful for components and devices requiring prolonged exposure to moisture or water, and for implanted biomedical devices (e.g. batteries, pacemakers, defibrillators, pumps).

    摘要翻译： 提供了硼酸钡硼酸盐密封玻璃组合物，其包括氧化硼（B 2 O 3），氧化钡（BaO），氧化镧（La 2 O 3）和选自以下的至少一种其它氧化物的各种组合（以摩尔％计）： 氧化铝（Al 2 O 3），氧化钙（CaO），氧化锂（Li 2 O），氧化钠（Na 2 O），二氧化硅（SiO 2）或二氧化钛（TiO 2）。 这些密封玻璃组合物可用于形成具有改善的水性耐久性和良好密封特性的钛和钛合金的密封玻璃 - 金属密封。 提供了密封玻璃组合物的实例，其热膨胀系数约为钛或钛合金的热膨胀系数，密封温度低于约900℃，通常约为700-800℃。钡硼酸钡密封玻璃 组合物可用于需要长时间暴露于水分或水分的部件和装置，以及植入的生物医学装置（如电池，起搏器，除颤器，泵）。

    Composition and method for radiation synovectomy of arthritic joints
    6.
    发明授权
    Composition and method for radiation synovectomy of arthritic joints 失效
    关节炎关节放射性滑膜切除术的组成和方法

    公开(公告)号：US4889707A

    公开(公告)日：1989-12-26

    申请号：US150154

    申请日：1988-01-29

    申请人： Delbert E. Day ,  Gary J. Ehrhardt

    发明人： Delbert E. Day ,  Gary J. Ehrhardt

    IPC分类号： A61K9/16 ,  A61K51/12

    CPC分类号： A61K9/1611 ,  A61K51/1258 ,  A61K2121/00

    摘要： Radioactive microspheres for radiation synovectomy of arithmetic joints in a mammal comprise a biodegradable glass material and a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout the glass material. The biodegradable glass material may be lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germanate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium, aluminoborate, potassium germanate or potassium aluminogermanate and the beta radiation emitting radioisotope may be samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 or yttrium-90. Methods for preparing such microspheres and for carrying out radiation synovectomy of arthritic joints utilizing such microspheres are also disclosed.

    摘要翻译： 放射性微球用于哺乳动物运算关节的放射性滑膜切除术包括可生物降解的玻璃材料和化学溶解并基本上均匀分布在玻璃材料中的β辐射放射性同位素。 可生物降解的玻璃材料可以是硅酸锂，铝硅酸锂，铝硼酸锂，锗酸锂，铝锗酸钾，硅酸钾，硅铝酸钾，钾，铝硼酸钾，锗酸钾或铝氟酸钾，β辐射放射性同位素可以是钐-153， 166，铒-169，镝-165，铼-188，铼-188或钇-90。 还公开了使用这种微球制备这种微球并进行关节炎关节的放射性滑膜切除术的方法。

    Scaffold for tissue regeneration in mammals
    7.
    发明授权
    Scaffold for tissue regeneration in mammals 有权
    用于哺乳动物组织再生的支架

    公开(公告)号：US08481066B2

    公开(公告)日：2013-07-09

    申请号：US12504489

    申请日：2009-07-16

    申请人： Delbert E. Day ,  Steven B. Jung ,  Roger F. Brown

    发明人： Delbert E. Day ,  Steven B. Jung ,  Roger F. Brown

    IPC分类号： A61F2/00

    CPC分类号： A61K33/22 ,  A61L27/10 ,  A61L27/56 ,  C03C3/14 ,  C03C3/19 ,  C03C4/0007 ,  C03C11/00 ,  C03C13/00

    摘要： A three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body components bonded to each other and made from component materials comprising about 40 to about 90 wt % B2O3, and two or more other oxides, wherein the scaffold body has a porosity between about 15 and about 90 vol %.

    摘要翻译： 具有用于修复组织的互连孔的三维支架，其包括用于组织支架的结构支撑的支架体，其中所述支架主体包括彼此结合并由包含约40至约90重量％B 2 O 3的组分材料制成的支架主体部件 ，以及两种或更多种其它氧化物，其中所述支架体的孔隙率为约15-约90体积％。

    Scaffolds with trace element for tissue regeneration in mammals
    8.
    发明授权
    Scaffolds with trace element for tissue regeneration in mammals 有权
    具有微量元素的支架用于哺乳动物中的组织再生

    公开(公告)号：US08287896B2

    公开(公告)日：2012-10-16

    申请号：US12683280

    申请日：2010-01-06

    申请人： Steven B. Jung ,  Delbert E. Day

    发明人： Steven B. Jung ,  Delbert E. Day

    IPC分类号： A61F2/02 ,  A61F2/00

    CPC分类号： A61L27/10 ,  A61F2/0077 ,  A61L27/58

    摘要： A scaffold for implantation into a mammal to facilitate vessel growth in repair, regeneration, and/or proliferation of bodily tissue, where the scaffold is based on a borate, silicate, or phosphate, glass-former and is biodegradable upon implantation in mammals. The scaffold includes one or more trace elements from the group consisting of Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn which are released into the host to support vessel growth. A method involves implantation of such scaffolds.

    摘要翻译： 用于植入哺乳动物以促进身体组织的修复，再生和/或增殖中的血管生长的支架，其中支架基于硼酸盐，硅酸盐或磷酸盐，玻璃形成物，并且在植入哺乳动物中时是可生物降解的。 支架包括一个或多个微量元素，其由释放到宿主中以支持血管生长的Cu，F，Fe，Mn，Mo，Ni，Sr和Zn组成的组中。 一种方法涉及植入这种支架。

    SCAFFOLDS WITH TRACE ELEMENT FOR TISSUE REGENERATION IN MAMMALS
    10.
    发明申请
    SCAFFOLDS WITH TRACE ELEMENT FOR TISSUE REGENERATION IN MAMMALS 有权
    具有追踪元素的组织元素在组织再生中的应用

    公开(公告)号：US20110165217A1

    公开(公告)日：2011-07-07

    申请号：US12683280

    申请日：2010-01-06

    申请人： Steven B. Jung ,  Delbert E. Day

    发明人： Steven B. Jung ,  Delbert E. Day

    IPC分类号： A61F2/06

    CPC分类号： A61L27/10 ,  A61F2/0077 ,  A61L27/58

    摘要： A scaffold for implantation into a mammal to facilitate vessel growth in repair, regeneration, and/or proliferation of bodily tissue, where the scaffold is based on a borate, silicate, or phosphate, glass-former and is biodegradable upon implantation in mammals. The scaffold includes one or more trace elements from the group consisting of Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn which are released into the host to support vessel growth. A method involves implantation of such scaffolds.

    摘要翻译： 用于植入哺乳动物以促进身体组织的修复，再生和/或增殖中的血管生长的支架，其中支架基于硼酸盐，硅酸盐或磷酸盐，玻璃形成物，并且在植入哺乳动物中时是可生物降解的。 支架包括一个或多个微量元素，其由释放到宿主中以支持血管生长的Cu，F，Fe，Mn，Mo，Ni，Sr和Zn组成的组中。 一种方法涉及植入这种支架。