公开(公告)号：US08530536B2

公开(公告)日：2013-09-10

申请号：US13227625

申请日：2011-09-08

Applicant: Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman ,  Indumathi Ramakrishnan ,  Anantharaman Dhanabalan ,  Mayank Kumar Dubey ,  Sumi Dinkar ,  Mayanglambam Rebika Devi ,  Markus Bley

Inventor： Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman ,  Indumathi Ramakrishnan ,  Anantharaman Dhanabalan ,  Mayank Kumar Dubey ,  Sumi Dinkar ,  Mayanglambam Rebika Devi ,  Markus Bley

IPC: C08J5/16

CPC classification number: A61M5/31513 ,  A61M2005/3131 ,  C10M169/04 ,  C10M2201/041 ,  C10M2201/061 ,  C10M2201/066 ,  C10M2201/103 ,  C10M2201/105 ,  C10M2205/20 ,  C10M2205/203 ,  C10M2207/126 ,  C10M2207/28 ,  C10M2207/283 ,  C10M2213/062 ,  C10M2215/08 ,  C10M2229/02 ,  C10M2229/025 ,  C10M2229/04 ,  C10M2229/051 ,  C10N2230/06 ,  C10N2240/66

Abstract: In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.

公开(公告)号：US20080213909A1

公开(公告)日：2008-09-04

申请号：US11857636

申请日：2007-09-19

Applicant: Daniel E. Haines ,  Rajendra J. Redkar ,  Luis A. Burzio ,  Samuel D. Conzone

Inventor： Daniel E. Haines ,  Rajendra J. Redkar ,  Luis A. Burzio ,  Samuel D. Conzone

IPC: G01N33/00

CPC classification number: G01N33/15 ,  G01N13/00 ,  G01N2013/006

Abstract: A pharmaceutical packaging assay for the determination of drug adsorption to the packaging surface(s) is described. The assay described utilizes fluorescent labeling of drugs in various formulations to determine the best packaging surface for drug stability as a function of adsorption.

Abstract translation: 描述了用于测定药物对包装表面的吸附的药物包装测定。 描述的测定法利用各种制剂中药物的荧光标记来确定作为吸附功能的药物稳定性的最佳包装表面。

公开(公告)号：US08618185B2

公开(公告)日：2013-12-31

申请号：US12896327

申请日：2010-10-01

Applicant: Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman

Inventor： Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman

IPC: C08J5/16

CPC classification number: A61M5/31513 ,  A61M2005/3131 ,  C10M169/04 ,  C10M2201/041 ,  C10M2201/061 ,  C10M2205/20 ,  C10M2205/203 ,  C10M2213/062 ,  C10M2229/025 ,  C10N2230/06 ,  C10N2240/66

Abstract: In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.

Abstract translation: 一方面，为药物包装组件提供自润滑部件。 自润滑组分包括聚合物组合物和有效量的润滑添加剂，例如氮化硼。 在另一方面，可以提供药物包装组件，其具有其表面涂覆有包含氮化硼的润滑组合物。 药物包装组合物可以是例如包括主体（筒）和柱塞组件的预填充注射器。

公开(公告)号：US07939339B2

公开(公告)日：2011-05-10

申请号：US11082518

申请日：2005-03-17

Applicant: Niko Schultz ,  Samuel D. Conzone ,  Otmar Becker ,  Dan Haines ,  Edgar Pawlowski ,  Volker Scheumann

Inventor： Niko Schultz ,  Samuel D. Conzone ,  Otmar Becker ,  Dan Haines ,  Edgar Pawlowski ,  Volker Scheumann

IPC: G01N21/00 ,  G01N33/551 ,  G01N33/552 ,  G01N33/553 ,  G01N21/64 ,  H04B1/02

CPC classification number: G01N21/6452 ,  G01N21/0303

Abstract: The invention relates to an arrangement for fluorescence amplification including a substrate, a fluorescence amplifier coating applied to the substrate, and a thin fluorescencable material which lies on the coating and emits light with the emission wavelength λE when it is exposed to excitation light of an excitation wavelength λA. The fluorescence amplifier coating includes an interference layer system of high-index and low-index dielectric layers, which reflects at least the excitation light. What is crucial for the design of the coating is that the fluorescencable material applied to the coating is arranged on the surface of the coating in the region of the maximum of the electric field amplitude of the standing wave with the excitation wavelength λA, which is formed during exposure to the excitation light.

Abstract translation: 本发明涉及一种用于荧光放大的装置，包括底物，施加到基底上的荧光放大器涂层，以及当被暴露于激发的激发光时位于涂层上并发射具有发射波长λE的光的薄的荧光发射材料 波长λA。 荧光放大器涂层包括至少反射激发光的高折射率和低折射率介电层的干涉层系统。 对涂层的设计至关重要的是，施加到涂层上的荧光材料在形成的激发波长λA的驻波的最大电场幅度的最大区域中被布置在涂层的表面上 在曝光期间激发光。

公开(公告)号：US20120065595A1

公开(公告)日：2012-03-15

申请号：US13227625

申请日：2011-09-08

Applicant: Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman ,  Indumathi Ramakrishnan ,  Anantharaman Dhanabalan ,  Mayank Kumar Dubey ,  Sumi Dinkar ,  Mayanglambam Rebika Devi ,  Markus Bley

Inventor： Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman ,  Indumathi Ramakrishnan ,  Anantharaman Dhanabalan ,  Mayank Kumar Dubey ,  Sumi Dinkar ,  Mayanglambam Rebika Devi ,  Markus Bley

IPC: A61M5/315 ,  C10M125/02

CPC classification number: A61M5/31513 ,  A61M2005/3131 ,  C10M169/04 ,  C10M2201/041 ,  C10M2201/061 ,  C10M2201/066 ,  C10M2201/103 ,  C10M2201/105 ,  C10M2205/20 ,  C10M2205/203 ,  C10M2207/126 ,  C10M2207/28 ,  C10M2207/283 ,  C10M2213/062 ,  C10M2215/08 ,  C10M2229/02 ,  C10M2229/025 ,  C10M2229/04 ,  C10M2229/051 ,  C10N2230/06 ,  C10N2240/66

Abstract: In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.

Abstract translation: 一方面，为药物包装组件提供自润滑部件。 自润滑组分包含聚合物组合物和有效量的润滑添加剂，例如氮化硼。 在另一方面，可以提供药物包装组件，其具有其表面涂覆有包含氮化硼的润滑组合物。 药物包装组合物可以是例如包括主体（筒）和柱塞组件的预填充注射器。

公开(公告)号：US20110082430A1

公开(公告)日：2011-04-07

申请号：US12896327

申请日：2010-10-01

Applicant: Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman

Inventor： Samuel D. Conzone ,  David M. Rusinko ,  Chandrashekar Raman

IPC: A61M5/315

CPC classification number: A61M5/31513 ,  A61M2005/3131 ,  C10M169/04 ,  C10M2201/041 ,  C10M2201/061 ,  C10M2205/20 ,  C10M2205/203 ,  C10M2213/062 ,  C10M2229/025 ,  C10N2230/06 ,  C10N2240/66

Abstract: In one aspect, a self-lubriating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.

Abstract translation: 在一个方面，为药物包装组件提供自我润湿部件。 自润滑组分包括聚合物组合物和有效量的润滑添加剂，例如氮化硼。 在另一方面，可以提供药物包装组件，其具有其表面涂覆有包含氮化硼的润滑组合物。 药物包装组合物可以是例如包括主体（筒）和柱塞组件的预填充注射器。

公开(公告)号：US06358531B1

公开(公告)日：2002-03-19

申请号：US09241492

申请日：1999-02-01

Applicant: Delbert E. Day ,  Samuel D. Conzone

Inventor： Delbert E. Day ,  Samuel D. Conzone

IPC: A61K914

CPC classification number: A61K9/501 ,  A61K9/1611 ,  C03C1/006 ,  C03C11/002 ,  C03C12/00 ,  Y10S977/775 ,  Y10S977/906

Abstract: A method is provided for preparing shells, concentric shells or porous, homogenous gels from alkali borate glass particles at low temperatures (i.e. room temperature or less than above 100° C.). The alkali borate glass particles contain one or more cations such as aluminum which react with an aqueous solution containing an anion such as hydroxide to form an aqueous insoluble material having a solubility limit of less than about 0.01 wt. percent. The resulting shells or gels may be used in many different applications such as a filler in resins, as filters, precursors for nano-sized powders, as thin surface films or catalyst support media. The resulting shells or gels may also have a chemotherapeutic drug added thereto, following which the resulting product is administered to a mammal and the insoluble material is dissolved form the product in vivo through administration of chelating agent.

Abstract translation: 提供了一种在低温（即室温或低于100℃）下从碱金属硼酸盐玻璃颗粒制备壳，同心圆壳或多孔同质凝胶的方法。 碱金属硼酸盐玻璃颗粒含有一种或多种阳离子例如铝，其与含有阴离子如氢氧化物的水溶液反应，形成溶解度极限小于约0.01重量％的水不溶性物质。 百分。 所得的壳或凝胶可用于许多不同的应用，例如树脂中的填料，作为过滤器，用于纳米尺寸粉末的前体，作为薄表面膜或催化剂载体介质。 所得的壳或凝胶也可以具有加入其中的化学治疗药物，随后将所得产物施用于哺乳动物，并且通过施用螯合剂在体内将不溶性物质从体内溶解。

公开(公告)号：US06882782B2

公开(公告)日：2005-04-19

申请号：US09855741

申请日：2001-05-16

Applicant: Samuel D. Conzone ,  Joseph S. Hayden ,  Alexander J. Marker, III ,  Marren Walther ,  Rainer Liebald ,  Ulrike Beer ,  Ulrich Peuschert ,  Ruediger Sprengard ,  Tobias Käleer

Inventor： Samuel D. Conzone ,  Joseph S. Hayden ,  Alexander J. Marker, III ,  Marren Walther ,  Rainer Liebald ,  Ulrike Beer ,  Ulrich Peuschert ,  Ruediger Sprengard ,  Tobias Käleer

IPC: G02B6/12 ,  G02B6/125 ,  G02B6/26 ,  G02B6/28 ,  G02B6/34 ,  G02B6/42

CPC classification number: G02B6/12019 ,  G02B6/12 ,  G02B6/12007 ,  G02B6/125 ,  G02B6/266 ,  G02B6/2804 ,  G02B6/29355 ,  G02B6/29395 ,  G02B6/4213 ,  G02B6/4215 ,  G02B6/424 ,  G02B6/4245 ,  G02B6/4246

Abstract: The invention concerns a photonic device comprising a first section including a material adapted to interact with photons, a second section including a material adapted to interact with photons, with an area of said first section and an area of said second section abutting each other wherein at least a part of said first area and a part of said second area defines a low temperature bonding area to provide adaptability for a plurality of applications based on a combination of materials having specific characteristic benefits, however without introducing unwanted effects having a negative influence on the quality of optical signals.

Abstract translation: 本发明涉及一种光子器件，其包括第一部分，该第一部分包括适于与光子相互作用的材料，第二部分，包括适于与光子相互作用的材料，所述第一部分的区域与所述第二部分的区域彼此邻接， 所述第一区域的至少一部分和所述第二区域的一部分限定低温粘合区域，以基于具有特定特征益处的材料的组合为多个应用提供适应性，然而不引入不利影响对 光信号质量。