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公开(公告)号：US08211465B2
公开(公告)日：2012-07-03
申请号：US13367504
申请日：2012-02-07
申请人： Der-Yang Lee , Frank Bunick , James Schwing
发明人： Der-Yang Lee , Frank Bunick , James Schwing
CPC分类号： A61K31/19 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K9/2866 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K31/192
摘要： A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.
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公开(公告)号：US20120136060A1
公开(公告)日：2012-05-31
申请号：US13367504
申请日：2012-02-07
申请人： Der-Yang Lee , Frank Bunick , James Schwing
发明人： Der-Yang Lee , Frank Bunick , James Schwing
IPC分类号： A61K31/192 , A61P29/00
CPC分类号： A61K31/19 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K9/2866 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K31/192
摘要： A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.
摘要翻译： 提供给予非甾体抗炎药物，特别是丙酸衍生物如布洛芬的方法。 本发明的剂型提供NSAID的初始释放和NSAID的第二次缓释，优选在单次给药步骤中。
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公开(公告)号：US08137694B2
公开(公告)日：2012-03-20
申请号：US11839168
申请日：2007-08-15
申请人： Der-Yang Lee , Frank Bunick , James Schwing
发明人： Der-Yang Lee , Frank Bunick , James Schwing
CPC分类号： A61K31/19 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K9/2866 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K31/192
摘要： A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.
摘要翻译： 提供给予非甾体抗炎药物，特别是丙酸衍生物如布洛芬的方法。 本发明的剂型提供NSAID的初始释放和NSAID的第二次缓释，优选在单次给药步骤中。
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公开(公告)号：US20090048345A1
公开(公告)日：2009-02-19
申请号：US11839168
申请日：2007-08-15
申请人： Der-Yang Lee , Frank Bunick , James Schwing
发明人： Der-Yang Lee , Frank Bunick , James Schwing
IPC分类号： A61K31/192
CPC分类号： A61K31/19 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K9/2866 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K31/192
摘要： A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.
摘要翻译： 提供给予非甾体抗炎药物，特别是丙酸衍生物如布洛芬的方法。 本发明的剂型提供NSAID的初始释放和NSAID的第二次缓释，优选在单次给药步骤中。
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公开(公告)号：US20050019376A1
公开(公告)日：2005-01-27
申请号：US10476503
申请日：2002-09-28
申请人： Gerard McNally , Frank Bunick , Harry Sowden , Gus LaBella , Timothy Gilmor , Der-Yang Lee , Martin Thomas
发明人： Gerard McNally , Frank Bunick , Harry Sowden , Gus LaBella , Timothy Gilmor , Der-Yang Lee , Martin Thomas
IPC分类号： A61K9/36 , A23G3/00 , A23G3/04 , A23G3/36 , A61J3/00 , A61J3/10 , A61K9/00 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/30 , A61K9/40 , A61K9/42 , A61K9/50 , A61K31/167 , A61K47/06 , A61K47/26 , A61K47/42 , A61P29/00 , A61P29/02 , B30B11/08 , B30B11/34 , A61K9/68
CPC分类号： A61J3/10 , A23G3/04 , A23G3/368 , A61J3/005 , A61K9/2853 , A61K9/2873 , A61K9/2893 , B30B11/08 , B30B11/34
摘要： A dosage form comprises an active ingredient and a confectionery composition. In one embodiment the relative standard deviation of the weight of the dosage form is less than 1%, and the dosage form has at least one face. In another embodiment, a dosage form comprising an active ingredient and a confectionery composition wherein the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission. The active ingredient may be a pharmaceutically active agent.
摘要翻译： 剂型包含活性成分和糖食组合物。 在一个实施方案中，剂型的重量的相对标准偏差小于1％，并且剂型具有至少一个面。 在另一个实施方案中，包含活性成分和糖食组合物的剂型，其中所述剂型具有至少一个面，不具有自由形成的表面，并且具有不大于最大消光角的平均偏振光透射率 比最大传播角度的剂型的平均偏振光透射。 活性成分可以是药物活性剂。
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公开(公告)号：US20050019407A1
公开(公告)日：2005-01-27
申请号：US10476529
申请日：2002-09-28
申请人： Harry Sowden , Frank Bunick , Gerard McNally , Der-Yang Lee , Martin Thomas
发明人： Harry Sowden , Frank Bunick , Gerard McNally , Der-Yang Lee , Martin Thomas
IPC分类号： A23G3/34 , A23G1/00 , A23G1/54 , A23G3/00 , A23G3/04 , A23G3/36 , A23G3/54 , A23L1/00 , A23L1/09 , A23L1/30 , A61J3/00 , A61J3/06 , A61J3/10 , A61K9/00 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/28 , A61K9/30 , A61K9/32 , A61K9/34 , A61K9/36 , A61K9/38 , A61K9/48 , A61K9/50 , A61K31/136 , A61K31/137 , A61K31/277 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61K47/46 , A61P11/00 , B30B11/08 , B30B11/34 , B30B15/30 , G06F17/30
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： A composite dosage form comprises at least one active ingredient, a first portion comprising a first molded material, and a second portion comprising a second material which is compositionally different from the first material. The first and second portions are joined at an interface, and a surface of the first portion at the interface resides substantially conformally upon a surface of the second portion of the interface. Either the first portion, the second portion, or a combination thereof may contain at least one active ingredient. The first portion, second portion or both may also each comprise an insert which may contain at least one active ingredient. The dosage form may also comprise a third portion which is located between the first and second portions.
摘要翻译： 复合剂型包含至少一种活性成分，第一部分包括第一模制材料，第二部分包含与第一材料成分不同的第二材料。 第一部分和第二部分在界面处接合，并且界面处的第一部分的表面基本上保形地驻留在界面的第二部分的表面上。 第一部分，第二部分或其组合可以含有至少一种活性成分。 第一部分，第二部分或两者也可各自包含可包含至少一种活性成分的插入物。 剂型还可以包括位于第一和第二部分之间的第三部分。
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公开(公告)号：US20080075766A1
公开(公告)日：2008-03-27
申请号：US11534845
申请日：2006-09-25
申请人： SHUN-POR LI , Hanspeter Naef , Frank Bunick , Der-Yang Lee
发明人： SHUN-POR LI , Hanspeter Naef , Frank Bunick , Der-Yang Lee
IPC分类号： A61K9/48
CPC分类号： A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/2853 , A61K9/2873 , A61K9/2893
摘要： The present invention is directed to a solid dosage form having at least two compressed portions and at least one light transmitting layer that is provided between said compressed portions. Each of said compressed portions having at least one surface area, a horizontal axis and a vertical axis. The light transmitting layer covers at least one surface of each compressed portions and is at least translucent along at least one axis of the compressed portions.
摘要翻译： 本发明涉及一种具有至少两个压缩部分和设置在所述压缩部分之间的至少一个透光层的固体剂型。 每个所述压缩部分具有至少一个表面积，水平轴线和垂直轴线。 光透射层覆盖每个压缩部分的至少一个表面，并且沿着压缩部分的至少一个轴线至少是半透明的。
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公开(公告)号：US09833510B2
公开(公告)日：2017-12-05
申请号：US11761698
申请日：2007-06-12
申请人： Der-Yang Lee , Robert Shen , Jen-Chi Chen , Vincent Chen
发明人： Der-Yang Lee , Robert Shen , Jen-Chi Chen , Vincent Chen
IPC分类号： A61K9/24 , A61K45/06 , A61K9/20 , A61K9/48 , A61K31/137 , A61K31/192 , A61K9/50
CPC分类号： A61K45/06 , A61K9/2081 , A61K9/4808 , A61K9/5073 , A61K9/5084 , A61K31/137 , A61K31/192 , A61K2300/00
摘要： A solid or semi-solid pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.
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公开(公告)号：US20090196908A1
公开(公告)日：2009-08-06
申请号：US12361162
申请日：2009-01-28
申请人： Der-Yang Lee , Priyashri Nayak
发明人： Der-Yang Lee , Priyashri Nayak
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61K9/0056 , A61K47/585
摘要： The present invention is directed to an edible film that contains a modified release active ingredient. The active ingredient may be present in the edible film a variety of forms, including a modified release matrix, in a modified release particulate form, in microgel liquid filled beads or in a bilayer film. The present invention also includes edible films which comprise additional immediate release active ingredients.
摘要翻译： 本发明涉及含有改性释放活性成分的可食用膜。 活性成分可以以微粒凝胶液体填充的珠粒或双层膜的形式存在于可调节的片剂中，包括改性释放基质，改性释放颗粒形式的各种形式。 本发明还包括包含另外的即时释放活性成分的可食用膜。
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公开(公告)号：US20090155372A1
公开(公告)日：2009-06-18
申请号：US12391475
申请日：2009-02-24
申请人： SHUN-POR LI , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
发明人： SHUN-POR LI , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
摘要翻译： 在一个实施方案中，剂型包含至少一种活性成分和模塑基质，其包含10-100％的熔点小于约100℃的材料，其选自热塑性聚环氧烷，低熔点疏水性 材料，热塑性聚合物，热塑性淀粉及其组合，并且所述基质能够在剂型与液体介质接触时提供活性成分的改性释放。 剂型还可以包含可以含有至少一种活性成分的未涂覆的颗粒。 在另一个实施方案中，剂型包含至少一种活性成分，多个颗粒和模制基质，其中至少一部分颗粒被涂覆。 涂覆的颗粒，基质或两者可以包含至少一种活性成分，并且涂覆的颗粒或基质或其组合能够在剂型与液体介质接触时提供活性成分的改性释放。
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