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    Modified release dosage forms
    2.
    发明授权
    Modified release dosage forms 有权
    改性释放剂型

    公开(公告)号：US08545887B2

    公开(公告)日：2013-10-01

    申请号：US10476530

    申请日：2002-09-28

    申请人： Harry S. Sowden ,  David Wynn ,  Shun-Por Li ,  Der-Yang Lee ,  Martin Thomas

    发明人： Harry S. Sowden ,  David Wynn ,  Shun-Por Li ,  Der-Yang Lee ,  Martin Thomas

    IPC分类号： A61J3/06 ,  A61K9/20 ,  B30B11/00 ,  A61K9/24 ,  G06F17/30

    CPC分类号： A23G3/04 ,  A23G1/54 ,  A23G3/0029 ,  A23G3/368 ,  A23G3/54 ,  A23L29/30 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0004 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2873 ,  A61K9/2886 ,  A61K9/2893 ,  A61K9/5084 ,  B30B11/08 ,  B30B11/34 ,  B30B15/302 ,  Y10T428/1352

    摘要： A dosage form comprises: (a) at least one active ingredient: (b) a core having a first surface portion upon which resides a first coating and a second surface portion which is substantially free of the first coating; and (c) a shell which resides upon at least a portion of the second surface portion, wherein the shell comprises a different material from the first coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core comprising a center portion having an exterior surface and an annular portion having an exterior surface and an interior surface, wherein the annular portion interior surface is in contact with at least a portion of the center portion exterior surface, and a coating resides on at least a portion of the annular portion exterior surface; and (c) a shell which resides upon at least a portion of the exterior surface of the center portion, wherein the shell comprises a different material than the impermeable coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface and a cavity which extends at least partially through the core such that the core outer surface has at least a first opening therein; (c) a first coating which resides on at least a portion of the core outer surface, wherein the first shell portion comprises a different material from the first coating; and (d) a first shell portion which is adjacent to the first opening and covers at least the first opening.

    摘要翻译： 剂型包括：（a）至少一种活性成分：（b）具有第一表面部分的核心，其上存在第一涂层和基本上不含第一涂层的第二表面部分; 和（c）位于第二表面部分的至少一部分上的外壳，其中外壳包括与第一涂层不同的材料。 在另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）芯部，其包括具有外表面的中心部分和具有外表面和内表面的环形部分，其中所述环形部分内表面与所述中心部分外表面的至少一部分接触， 位于环形部分外表面的至少一部分上; 和（c）驻留在中心部分的外表面的至少一部分上的壳体，其中壳体包括与不可渗透涂层不同的材料。 在另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）具有外表面和空腔的芯体，其至少部分地穿过所述芯部，使得所述芯部外表面至少具有第一开口; （c）驻留在所述芯外表面的至少一部分上的第一涂层，其中所述第一壳部分包括与所述第一涂层不同的材料; 和（d）与第一开口相邻并且至少覆盖第一开口的第一壳体部分。

    METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS
    5.
    发明申请
    METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS 审中-公开
    制造改良释放剂量形式的方法

    公开(公告)号：US20090186082A1

    公开(公告)日：2009-07-23

    申请号：US12360579

    申请日：2009-01-27

    申请人： Shun-Por LI ,  David Wynn ,  Narendra Parikh ,  Dan McTeigue ,  Harry S. Sowden ,  Martin Thomas ,  Der-Yang Lee

    发明人： Shun-Por LI ,  David Wynn ,  Narendra Parikh ,  Dan McTeigue ,  Harry S. Sowden ,  Martin Thomas ,  Der-Yang Lee

    IPC分类号： A61K9/22

    CPC分类号： A61J3/10 ,  A23G3/04 ,  A23G3/368 ,  A61J3/005 ,  A61K9/2853 ,  A61K9/2873 ,  A61K9/2893 ,  B30B11/08 ,  B30B11/34

    摘要： In one embodiment, a dosage form comprises: (a) at least one active ingredient; (b) a molded core which is solid at room temperature; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment of this invention, a dosage form comprises: (a) at least one active ingredient; (b) a molded core comprising a plurality of particles; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium.

    摘要翻译： 在一个实施方案中，剂型包含：（a）至少一种活性成分; （b）在室温下为固体的模制芯; 和（c）与芯的至少一部分接触的壳，其中所述剂型在剂型与液体介质接触时提供活性成分的改性释放。 在本发明的另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）包含多个颗粒的成型芯; 和（c）与芯的至少一部分接触的壳，其中所述剂型在剂型与液体介质接触时提供活性成分的改性释放。

    Composite dosage forms having an inlaid portion
    6.
    发明授权
    Composite dosage forms having an inlaid portion 有权
    具有镶嵌部分的复合剂型

    公开(公告)号：US07807197B2

    公开(公告)日：2010-10-05

    申请号：US10476388

    申请日：2002-09-28

    申请人： Der-Yang Lee ,  Harry S. Sowden ,  Martin Thomas

    发明人： Der-Yang Lee ,  Harry S. Sowden ,  Martin Thomas

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/24

    CPC分类号： A61K9/209 ,  A61K9/2072 ,  A61K9/2086 ,  A61K9/2095 ,  A61K9/2893

    摘要： A dosage form comprises at least one active ingredient, a first portion which comprises an exterior surface and one or more cavities defining at least one interior surface having indentations and an exterior surface, and a second molded portion which is inlaid into the cavities of the first portion and has an exterior surface. The first and second portions are in contact at an interface, the second portion comprises a solidified thermoplastic material, and the second portion resides substantially conformally upon the indentations of the first portion. In another embodiment, a dosage form comprises at least one active ingredient, a core having an outer surface and a shell residing on at least a portion of the core outer surface, wherein the shell comprises a first shell portion and a second molded shell portion which is inlaid into the first shell portion. In another embodiment, a dosage form comprises at least one active ingredient, a core, and a shell having a first molded shell portion which is discontinuous, and a second molded shell portion which is continuous, such that the discontinuities of the first shell portion are due to the presence of the second molded shell portion, and the first and second shell portions are compositionally different.

    摘要翻译： 剂型包括至少一种活性成分，第一部分包括外表面和限定至少一个具有凹痕和外表面的内表面的一个或多个空腔，以及第二模制部分，其嵌入第一 并具有外表面。 第一部分和第二部分在界面处接触，第二部分包括凝固的热塑性材料，第二部分基本上保持在第一部分的凹陷上。 在另一个实施方案中，剂型包含至少一种活性成分，具有外表面的芯和位于芯外表面的至少一部分上的壳，其中所述壳包括第一壳部分和第二模制壳部分， 嵌入第一壳部分。 在另一个实施方案中，剂型包含至少一种活性成分，核心和壳，其具有不连续的第一模塑壳部分和连续的第二模制壳部分，使得第一壳部分的不连续性为 由于存在第二模制壳体部分，并且第一和第二壳部分在组成上是不同的。

    Fuel Cell Stacks
    9.
    发明申请
    Fuel Cell Stacks 有权
    燃料电池堆

    公开(公告)号：US20130059222A1

    公开(公告)日：2013-03-07

    申请号：US13695453

    申请日：2011-05-09

    申请人： Martin Thomas

    发明人： Martin Thomas

    IPC分类号： H01M2/38 ,  H01M8/04

    CPC分类号： H01M8/08 ,  H01M8/083 ,  H01M8/2445 ,  H01M8/2459 ,  H01M8/2483 ,  Y02E60/50

    摘要： A fuel cell stack (10) comprises a plurality of fuel cells each with a chamber (K) for electrolyte with at least one inlet and at least one outlet, and at least one header (30) to supply electrolyte to all the cells in parallel, and means (14) to collect electrolyte that has flowed through the cells. For each cell, the electrolyte outlets (34) feed into an electrolyte flow channel arranged such that in use there is a free surface of electrolyte within the electrolyte flow channel, the electrolyte flow channel being separate from the corresponding electrolyte flow channels for other cells, but such that the free surfaces of all the electrolyte flow channels are at a common pressure. Electrolyte is maintained at a constant depth in this open flow channel by a weir (38), and then flows over the weir to trickle or drip down the outside of the stack. This ensures uniform outlet electrolyte pressure throughout the stack (10) and across the individual cells, and avoids or reduces ionic leakage currents through the electrolyte outlets.

    摘要翻译： 燃料电池堆（10）包括多个燃料电池，每个燃料电池具有用于电解质的室（K），其具有至少一个入口和至少一个出口，以及至少一个头部（30），以平行地向所有电池供应电解质 ，以及用于收集已经流过细胞的电解质的装置（14）。 对于每个电池，电解质出口（34）进入电解质流动通道，其布置使得在使用中在电解质流动通道内存在电解质的自由表面，电解质流动通道与用于其它电池的相应的电解质流动通道分开， 但是使得所有电解质流动通道的自由表面处于共同的压力。 电解液通过堰（38）在这个开放的流动通道中保持恒定的深度，然后流过堰，涓流或滴落在堆垛外面。 这确保整个堆叠（10）和跨单独电池均匀的出口电解液压力，并避免或减少通过电解液出口的离子泄漏电流。

    Membrane electrode assembly with hydrogenatable material for a fuel cell
    10.
    发明授权
    Membrane electrode assembly with hydrogenatable material for a fuel cell 有权
    具有用于燃料电池的可氢化材料的膜电极组件

    公开(公告)号：US08283081B2

    公开(公告)日：2012-10-09

    申请号：US12208411

    申请日：2008-09-11

    申请人： Andreas Huth ,  Christiane Jacksch ,  Martin Thomas

    发明人： Andreas Huth ,  Christiane Jacksch ,  Martin Thomas

    IPC分类号： H01M8/02 ,  H01M8/04 ,  H01M8/10

    CPC分类号： H01M8/04067 ,  C01B6/02 ,  C01B6/04 ,  C01B6/24 ,  H01M4/8605 ,  H01M4/8642 ,  H01M8/04216 ,  H01M8/04268 ,  H01M2008/1095

    摘要： The invention relates to a membrane-electrode assembly for a fuel cell with a proton-conducting membrane two catalyst layers adjoining both sides of the membrane, wherein the catalyst layers have an electrically conductive base material and at least one catalytic material deposited on the base material, and two gas diffusion layers adjoining the catalyst layers. The membrane and/or at least one of the catalyst layers and/or at least one of the gas diffusion layers includes at least one hydrogenatable material capable of binding hydrogen in a reversible exothermic hydrogenation operation by forming a hydride, depending on the temperature and/or pressure. The hydrogenatable material can be distributed in the gas diffusion layer and/or in the catalyst layer or can be present as a separate layer on at least one side of the gas diffusion electrode or the membrane.

    摘要翻译： 本发明涉及一种用于燃料电池的膜 - 电极组件，其具有质子传导膜，两个邻近膜两侧的催化剂层，其中催化剂层具有导电基材和沉积在基材上的至少一种催化材料 和与催化剂层相邻的两个气体扩散层。 膜和/或至少一个催化剂层和/或至少一个气体扩散层包括至少一种能够通过形成氢化物在可逆放热加氢操作中结合氢的至少一种可氢化材料，这取决于温度和/ 或压力。 可氢化材料可以分布在气体扩散层和/或催化剂层中，或者可以在气体扩散电极或膜的至少一侧作为单独的层存在。