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    Method of Producing Natural B Carotene By Fermentation And Use Thereof
    4.
    发明申请
    Method of Producing Natural B Carotene By Fermentation And Use Thereof 有权
    通过发酵和使用生产天然B胡萝卜素的方法

    公开(公告)号：US20140187829A1

    公开(公告)日：2014-07-03

    申请号：US14119149

    申请日：2012-05-15

    申请人： Xinde Xu ,  Mingqing Jiao ,  Dong Shao ,  Bin Shao ,  Leiming Yu

    发明人： Xinde Xu ,  Mingqing Jiao ,  Dong Shao ,  Bin Shao ,  Leiming Yu

    IPC分类号： C12P23/00

    CPC分类号： C12P23/00 ,  A23L5/44 ,  A23L33/155 ,  A23V2002/00 ,  A61K31/015 ,  A23V2250/702

    摘要： The present invention provides a method for producing and purifying β-carotene by Blakeslea trispora fermentation and use thereof. The method comprises the following steps: a) separately inoculating the Blakeslea trispora strains onto a PDA culture medium so as to obtain a spore suspension; b) propagating spores in a seeding tank so as to obtain seeds for fermentation; c) inoculating the seeds for fermentation onto a fermenter and fermenting said seeds; d) adjusting the fermentation liquid to be basic by using an organic or inorganic base, and filtering so as to obtain wet mycelia; e) treating the wet mycelia with a hydrophobic non-polar organic solvent; f) mixing the wet mycelia with an organic solvent of ester and obtaining a concentrated solution by extracting; g) adding a saturated monohydric alcohol into the concentrated solution, and filtering and crystallizing so as to obtain pure ss-carotene. The content of the ss-carotene in the present invention exceeds 96%, and the yield is above 85%.

    摘要翻译： 本发明提供了通过三孢a菌发酵及其应用来生产和提纯β-胡萝卜素的方法。 该方法包括以下步骤：a）将单孢菌菌株分别接种到PDA培养基上，得到孢子悬浮液; b）在播种槽中繁殖孢子，以获得用于发酵的种子; c）将种子接种发酵到发酵罐上并发酵所述种子; d）通过使用有机或无机碱调节发酵液为碱性，过滤以获得湿菌丝体; e）用疏水性非极性有机溶剂处理湿菌丝体; f）将湿菌丝体与酯的有机溶剂混合，通过萃取获得浓缩溶液; g）向浓缩溶液中加入饱和一元醇，过滤结晶，得到纯β-胡萝卜素。 本发明中β-胡萝卜素的含量超过96％，收率高于85％。

    Benzenesulfonamide compounds and the use thereof
    5.
    发明授权
    Benzenesulfonamide compounds and the use thereof 有权
    苯磺酰胺化合物及其用途

    公开(公告)号：US08765736B2

    公开(公告)日：2014-07-01

    申请号：US12599608

    申请日：2008-09-26

    申请人： Bin Shao ,  Jiangchao Yao

    发明人： Bin Shao ,  Jiangchao Yao

    IPC分类号： A01N43/00 ,  A61K31/55 ,  A01N43/42 ,  A61K31/44 ,  A01N43/38 ,  A61K31/40

    CPC分类号： C07D211/58 ,  C07D401/04

    摘要： The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

    摘要翻译： 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1，R2，R3，Z和q如说明书所述定义。 本发明还涉及使用式I化合物来治疗对阻断钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。

    Method of preparing oil suspensions of carotenoid with low viscosity and high fluidity and use thereof
    6.
    发明授权
    Method of preparing oil suspensions of carotenoid with low viscosity and high fluidity and use thereof 有权
    制备低粘度和高流动性的类胡萝卜素油悬浮液的方法及其用途

    公开(公告)号：US08748495B2

    公开(公告)日：2014-06-10

    申请号：US13255271

    申请日：2010-03-04

    申请人： Xinde Xu ,  Guohua Wei ,  Xuebing Xiang ,  Bin Shao

    发明人： Xinde Xu ,  Guohua Wei ,  Xuebing Xiang ,  Bin Shao

    IPC分类号： A61K31/122

    CPC分类号： A23L33/105 ,  A23L5/44 ,  A23L33/10 ,  A23V2002/00 ,  A23V2250/211

    摘要： The present invention relates to a method for preparing a carotenoid oil suspension with low viscosity and high fluidity. The method includes the steps of mixing carotenoid crystals with tetrahydrofuran, heating the resulting mixture to a reflux temperature of about 50˜70° C. under stirring, and filtering-the resulting solution to remove fat-soluble fibers. The resulting filtrate is then condensed to dryness, mixed with a ketone solvent, heated to a reflux temperature of about 60˜80° C., and filtered to remove non-soluble phospholipids. The filtrate obtained is condensed to a residue, and absolute alcohol is added to the residue, and then crystallized under stirring at room temperature. The resulting crystals are filtered and dried to-provide carotenoid crystals. The carotenoid crystals are ground and mixed with plant oils to provide a carotenoid oil suspension with low viscosity and high fluidity, which provides easy filling, for example, into capsules.

    摘要翻译： 本发明涉及一种制备低粘度和高流动性的类胡萝卜素油悬浮液的方法。 该方法包括将胡萝卜素晶体与四氢呋喃混合的步骤，在搅拌下将所得混合物加热至约50℃至70℃的回流温度，并过滤所得溶液以除去脂溶性纤维。 然后将所得滤液冷凝至干，与酮溶剂混合，加热至约60〜80℃的回流温度，过滤除去不溶性磷脂。 将得到的滤液冷凝成残渣，向残渣中加入无水乙醇，在室温下搅拌结晶。 将所得晶体过滤并干燥以提供类胡萝卜素晶体。 将类胡萝卜素晶体研磨并与植物油混合，以提供低粘度和高流动性的类胡萝卜素油悬浮液，其可以容易地填充到例如胶囊中。

    CURRENT CONTROLLING CIRCUIT FOR A LIGHT-EMITTING DIODE DRIVER AND PRODUCING METHOD THEREFOR
    8.
    发明申请
    CURRENT CONTROLLING CIRCUIT FOR A LIGHT-EMITTING DIODE DRIVER AND PRODUCING METHOD THEREFOR 有权
    用于发光二极管驱动器的电流控制电路及其制造方法

    公开(公告)号：US20130076252A1

    公开(公告)日：2013-03-28

    申请号：US13548624

    申请日：2012-07-13

    申请人： Bin Shao ,  Kenji Tomiyoshi

    发明人： Bin Shao ,  Kenji Tomiyoshi

    IPC分类号： H05B33/08 ,  G05F1/46

    CPC分类号： H05B33/0842 ,  G05F1/46 ,  H05B33/0824

    摘要： The present disclosure proposes a fully integrated accurate LED output current controlling circuit and method, which can be seamlessly combined with true PWM dimming. The current controlling circuit has an auto zero function in the light-emitting diode driver to eliminate offsets caused by the system, process variations, parasitic effects, dimming and so on in an LED driver application, and thus is capable of controlling the LED current with high accuracy. Moreover, the driver of the present disclosure does not require the use of external components such as an external resistor to regulate current accuracy.

    摘要翻译： 本公开提出了一种完全集成的准确的LED输出电流控制电路和方法，其可以与真实的PWM调光无缝组合。 电流控制电路在发光二极管驱动器中具有自动调零功能，以消除LED驱动器应用中由系统引起的偏移，工艺变化，寄生效应，调光等，从而能够控制LED电流 高准确率。 此外，本公开的驱动器不需要使用诸如外部电阻器的外部组件来调节电流精度。