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93 条记录 (耗时 0.033 秒)

    Method and device for continuous production of polymers
    1.
    发明授权
    Method and device for continuous production of polymers 失效
    用于连续生产聚合物的方法和装置

    公开(公告)号：US06555629B1

    公开(公告)日：2003-04-29

    申请号：US09673156

    申请日：2000-11-14

    申请人： Detlev Pysall ,  Olaf Wachsen ,  Thomas Bayer ,  Stefan Wulf

    发明人： Detlev Pysall ,  Olaf Wachsen ,  Thomas Bayer ,  Stefan Wulf

    IPC分类号： C08F204

    CPC分类号： B01F13/0059 ,  B01F5/0403 ,  B01F2005/0031 ,  B01F2015/062 ,  B01F2215/0049 ,  B01J19/0093 ,  B01J19/242 ,  B01J2219/00889 ,  B29K2105/0002

    摘要： Process and apparatus for the continuous preparation of polymers Two reaction partners (starting materials) are stored in separate reservoirs 2, 3, 4 and 5 and are transported using overpressure via heated heat exchangers 11, 12 into a micromixer 18 by means of control and metering devices 6, 7, which can be metering pumps. In the heat exchangers 11, 12, the starting materials are heated, separately in each case, to the extent that during the mixing operation in the micromixer 18 the required reaction temperature is immediately reached. The polymerization takes place in a downstream tube reactor 20 which consists of tubes 21, 22, 23 which are connected in series.

    摘要翻译： 用于连续制备聚合物的方法和设备将两个反应物（起始物料）储存在分开的储存器2,3,4和5中，并通过加热的热交换器11,12通过超压将其通过控制和计量运送到微混合器18中 装置6,7可以是计量泵。 在热交换器11,12中，原料在各种情况下分别被加热到在微混合器18的混合操作期间立即达到所需的反应温度的程度。 聚合发生在下游管式反应器20中，其由串联连接的管21,22,23组成。

    MONOCLONAL ANTIBODIES TARGETING AMYLOID BETA OLIGOMERS
    3.
    发明申请
    MONOCLONAL ANTIBODIES TARGETING AMYLOID BETA OLIGOMERS 有权
    单克隆抗体靶向AMYLOID BETA寡聚体

    公开(公告)号：US20130295095A1

    公开(公告)日：2013-11-07

    申请号：US13701758

    申请日：2011-06-03

    申请人： Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

    发明人： Thomas Bayer ,  Oliver Wirths ,  Henrik Martens ,  Christian Erck

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/76

    摘要： The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated Aβ starting with pyroglutamate (AβρE), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing Aβ oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM AC-C3056. Further, the invention provides a method of inhibiting the formation or the seeding effect of said AβρE oligomers, and a method for identifying agents useful in the treatment and/or prevention of an amyloid-related disorder as well as methods of diagnosing a subject suspected of suffering from a disease associated with amyloidogenesis and/or amyloid plaque formation and to methods of monitoring the efficacy of a treatment of a disease associated with amyloidogenesis and/or amyloid-plaque formation characterized by the presence of Aβ oligomers in a subject.

    摘要翻译： 本发明涉及能够特异性识别由焦谷氨酸（AbetarhoE）开始的N-末端截短的Abeta的可溶性低聚物，包含其的药物组合物及其各自的治疗用途的结合分子。 特别地，本发明涉及能够特异性识别Aβ寡聚体的抗体分子，其中所述抗体结合和/或检测由DSM AC-C3056沉积的抗体PG3-38 9D5H6结合和/或检测的表位。 此外，本发明提供抑制所述AbetarhoE寡聚体的形成或播种作用的方法，以及用于鉴定可用于治疗和/或预防淀粉样蛋白相关病症的药剂的方法以及诊断疑似患者的方法 患有与淀粉样变性和/或淀粉样蛋白斑形成相关的疾病，以及监测治疗与淀粉样变性和/或淀粉样蛋白斑形成有关的疾病的功效的方法，其特征在于受试者中存在Aβ寡聚体。

    METHOD FOR OPTIMALLY OPERATING TRANSMISSIONS
    5.
    发明申请
    METHOD FOR OPTIMALLY OPERATING TRANSMISSIONS 有权
    最佳运行方式

    公开(公告)号：US20100089163A1

    公开(公告)日：2010-04-15

    申请号：US12595277

    申请日：2008-04-02

    申请人： Michael Engelbreit ,  Thomas Bayer

    发明人： Michael Engelbreit ,  Thomas Bayer

    IPC分类号： G01M13/02

    CPC分类号： G01M13/021

    摘要： A method for optimally operating mechanically loaded, moved, particularly rotating components, such as gearboxes, wherein in the operating stage damage accumulation is used to evaluate the influence of a collective load on the lifespan of the loaded rotating components, the moving components (1) being divided into a plurality of segments (5-10) for determining individual collective loads (6; 18).

    摘要翻译： 用于最佳地操作机械负载的，移动的，特别是旋转的部件（例如齿轮箱）的方法，其中在操作阶段损伤积累用于评估集合载荷对所加载的旋转部件的寿命的影响，移动部件（1） 被分成多个段（5-10），用于确定各个集体负荷（6; 18）。

    Linear drive, in particular a rack and pinion drive
    6.
    发明申请
    Linear drive, in particular a rack and pinion drive 审中-公开
    线性驱动，特别是齿条齿轮传动

    公开(公告)号：US20090320630A1

    公开(公告)日：2009-12-31

    申请号：US10588747

    申请日：2004-11-23

    申请人： Thomas Bayer ,  Frank Michel

    发明人： Thomas Bayer ,  Frank Michel

    IPC分类号： F16H55/28

    CPC分类号： F16H55/28 ,  B23Q5/385 ,  B23Q5/56 ,  F16H2057/123 ,  Y10T74/19623

    摘要： The invention relates to a linear drive, in particular a rack and pinion drive, comprising at least one motor element (2) which is mounted on or in a retaining element (1.1, 1.2). The motor element (2) drives, directly or indirectly, a pinion (4), optionally, via an integrated drive (3), said pinion co-operating with a linear guide (5). According to the invention, the retaining element (1.1, 1.2) can be displaced by at least one actuator (12.1 to 12.3) in relation to a receiving element (6).

    摘要翻译： 本发明涉及线性驱动器，特别是齿条和小齿轮驱动器，其包括安装在保持元件（1.1,1.2）上或其中的至少一个马达元件（2）。 马达元件（2）直接或间接地驱动小齿轮（4），可选地通过集成驱动器（3）驱动，所述小齿轮与直线导轨（5）配合。 根据本发明，保持元件（1.1,1.2）可以相对于接收元件（6）由至少一个致动器（12.1至12.3）移位。

    Method for reading document entries and addresses
    9.
    发明授权
    Method for reading document entries and addresses 有权
    读取文件条目和地址的方法

    公开(公告)号：US06993155B1

    公开(公告)日：2006-01-31

    申请号：US09913278

    申请日：2000-02-01

    申请人： Hartmut Schäfer ,  Thomas Bayer

    发明人： Hartmut Schäfer ,  Thomas Bayer

    IPC分类号： G06K9/00

    CPC分类号： G06K9/00442 ,  G06K9/6217

    摘要： The invention relates to a method for reading document entries and addresses. In this context, automatic reading is effected using the intermediate steps of layout analysis, classification of the segmented regions and interpretation of the results in a reader, and if necessary video coding. According to the invention, during the reading mode, when information has been clearly read automatically, the image data and the associated reading results and intermediate results, and/or, when information has been clearly ascertained using video coding, the image data and the reading results and intermediate results clearly ascertained in a second automatic reading process including the video coding results are stored for a current random sample. This current random sample is used to readapt the automatic reader.

    摘要翻译： 本发明涉及一种用于读取文档条目和地址的方法。 在这种情况下，使用布局分析的中间步骤，分段区域的分类和读取器中的结果的解释以及必要的视频编码来实现自动阅读。 根据本发明，在读取模式期间，当信息已经被清楚地读取时，图像数据和相关联的读取结果和中间结果，和/或当使用视频编码清楚地确定了信息时，图像数据和读取 在包括视频编码结果的第二自动读取处理中清楚地确定的结果和中间结果被存储用于当前的随机样本。 该当前的随机样本用于自动读取器。

    Low-play planetary gear mechanism
    10.
    发明授权
    Low-play planetary gear mechanism 有权
    低调行星齿轮机构

    公开(公告)号：US06432022B1

    公开(公告)日：2002-08-13

    申请号：US09575079

    申请日：2000-05-19

    申请人： Thomas Bayer

    发明人： Thomas Bayer

    IPC分类号： F16H5704

    CPC分类号： F16H57/0482 ,  Y10S475/901 ,  Y10T74/19977

    摘要： A low-play planetary gear mechanism for high rotational speeds and low torque transmission and having roller bearings for the parts which rotate within the gear mechanism. The gear mechanism is designed for a long, maintenance-free service life in continuous operation at high drive speeds. To accomplish this, the running surfaces of at least some of the gears are coated with a coating that has a higher wear resistance and a lower coefficient of friction than the respectively associated base material. As such, all of the surfaces of the gear mechanism which come into contact with one another are able to run for long periods at the end of assembly of the gear mechanism. With this gear mechanism, there is no circulating lubricating oil originating from a lubricating-oil collection chamber and which flows freely around any of the moving parts of the gear mechanism.

    摘要翻译： 一种低转速行星齿轮机构，用于高转速和低转矩传动，并具有用于在齿轮机构内旋转的部件的滚子轴承。 齿轮机构设计用于在高驱动速度下连续运行的长期，免维护的使用寿命。 为了实现这一点，至少一些齿轮的运行表面涂覆有比相应的基材具有更高的耐磨性和较低的摩擦系数的涂层。 因此，齿轮机构的彼此接触的所有表面能够在齿轮机构的组装结束时能够长时间运行。 利用这种齿轮机构，不存在来自润滑油收集室的循环润滑油，并且能够绕齿轮机构的任何运动部件自由流动。