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公开(公告)号：US08703117B2
公开(公告)日：2014-04-22
申请号：US13555656
申请日：2012-07-23
申请人： Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人： Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
CPC分类号： A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要： Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译： 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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2.发明授权Dry composition wound dressings and adhesives comprising gelatin and transglutaminase in a cross-linked matrix 有权干组合伤口敷料和包含明胶和转谷氨酰胺酶在交联基质中的粘合剂公开(公告)号：US08961544B2
公开(公告)日：2015-02-24
申请号：US13813814
申请日：2011-08-05
申请人： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
发明人： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61L15/325 , A61L15/38 , A61L15/425 , A61L31/045 , A61L31/047 , A61L31/14
摘要： Patches comprising dry gelatin compositions.
摘要翻译： 贴剂包括干明胶组合物。
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公开(公告)号：US20120329132A1
公开(公告)日：2012-12-27
申请号：US13555656
申请日：2012-07-23
申请人： Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人： Orahn Preiss BLOOM , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC分类号： C12N9/10
CPC分类号： A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要： Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译： 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白质包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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公开(公告)号：US20110110882A1
公开(公告)日：2011-05-12
申请号：US13000021
申请日：2009-06-18
申请人： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人： Orahn Preiss-Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
IPC分类号： A61K31/785 , A61K38/45 , A61P3/00
CPC分类号： A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要： Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
摘要翻译： 包含可交联蛋白质或多肽的改进的组合物和诱导可交联蛋白质交联的无毒材料。 组合物任选且优选在非磷酸缓冲溶剂中制备。 任选且优选地，可交联蛋白包括本文所述的明胶和任何明胶变体或变体蛋白质。 任选且优选地，无毒材料包含转谷氨酰胺酶（TG），其可以任选地包含任何类型的钙依赖性或独立的转谷氨酰胺酶，其可以例如任选地是微生物转谷氨酰胺酶（mTG）。
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公开(公告)号：US20130131701A1
公开(公告)日：2013-05-23
申请号：US13813814
申请日：2011-08-05
申请人： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
发明人： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
IPC分类号： A61F2/00
CPC分类号： A61F2/0063 , A61L15/325 , A61L15/38 , A61L15/425 , A61L31/045 , A61L31/047 , A61L31/14
摘要： Patches comprising dry gelatin compositions and methods of use and manufacture thereof.
摘要翻译： 包含干明胶组合物的胶料及其使用和制造方法。
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公开(公告)号：US08367388B2
公开(公告)日：2013-02-05
申请号：US13000021
申请日：2009-06-18
申请人： Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
发明人： Orahn Preiss Bloom , Ishay Attar , Natalie Iram , Chagai Komlos , Meir Haber
CPC分类号： A61K38/39 , A61K8/042 , A61K8/20 , A61K8/36 , A61K8/365 , A61K8/60 , A61K8/65 , A61K8/66 , A61K9/0014 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46 , A61L15/24 , A61L15/26 , A61L15/32 , A61L26/0014 , A61L26/0019 , A61L26/0038 , A61Q19/00 , C08H1/06 , C08L89/06 , C08L29/04 , C08L71/02
摘要： Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
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