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    Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
    4.
    发明申请
    Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) 审中-公开
    预防急性和延迟化疗引起的恶心呕吐（CINV）的方法

    公开(公告)号：US20070265329A1

    公开(公告)日：2007-11-15

    申请号：US11433917

    申请日：2006-05-12

    申请人： Shah Devang ,  John Barr ,  Brian Baxter ,  Jorge Heller

    发明人： Shah Devang ,  John Barr ,  Brian Baxter ,  Jorge Heller

    IPC分类号： A61K31/405

    CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K31/405 ,  A61K47/14 ,  A61K47/34

    摘要： A pharmaceutical composition for the sustained release of an effective amount of a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist for the prevention, reduction or alleviation of acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a course of emetogenic chemotherapy, wherein the composition is administered by subcutaneous injection, the composition comprising a 5-HT3 receptor antagonist, a semi-solid delivery vehicle and a pharmaceutically acceptable liquid excipient; wherein the composition, when administered in a single dosage, provides a controlled release of the 5-HT3 receptor antagonist and prolonging the release of the 5-HT3 receptor antagonist that tracks the profile of the incidence of vomiting.

    摘要翻译： 用于持续释放有效量的选择性5-羟色胺3（5-HT 3 N）受体拮抗剂用于预防，减少或缓解急性和延迟化疗引起的恶心和呕吐的药物组合物 （CINV），其中所述组合物通过皮下注射施用，所述组合物包含5-HT 3受体拮抗剂，半固体递送载体和药学上可接受的液体赋形剂; 其中当以单一剂量施用时，所述组合物提供5-HT 3受体拮抗剂的受控释放并延长5-HT 3受体拮抗剂的释放，所述5-HT 3受体拮抗剂的释放 跟踪呕吐发生的概况。

    LASER SYSTEM AND METHOD OF OPERATION
    5.
    发明申请
    LASER SYSTEM AND METHOD OF OPERATION 有权
    激光系统和操作方法

    公开(公告)号：US20130250995A1

    公开(公告)日：2013-09-26

    申请号：US13988521

    申请日：2011-11-21

    申请人： John Barr ,  Andrew White ,  Stephen Moore

    发明人： John Barr ,  Andrew White ,  Stephen Moore

    IPC分类号： H01S5/04

    CPC分类号： H01S3/08059 ,  H01S3/0606 ,  H01S3/08 ,  H01S3/08095 ,  H01S3/091 ,  H01S3/093 ,  H01S3/0933 ,  H01S3/094084 ,  H01S3/094096 ,  H01S3/0941 ,  H01S3/1022 ,  H01S3/1608 ,  H01S3/1611 ,  H01S3/1643 ,  H01S5/041 ,  H01S5/4025 ,  H01S5/4087

    摘要： An exemplary laser system is disclosed which includes a pump laser diode array and laser gain material, in which the array generates optical radiation having a predetermined total linewidth approximately 20 nm wide constructed from a plurality of individual wavelengths with a linewidth of up to 8 nm, the centre wavelength of radiation being for example within the absorption band of laser gain material used at the centre point of the operating temperature of the array. The system can include a highly reflecting plane mirror with periodic transmitting patches placed between the laser diode array and the laser gain material, the size of the transmitting patches being such that minimal pump radiation is lost.

    摘要翻译： 公开了一种示例性的激光系统，其包括泵浦激光二极管阵列和激光增益材料，其中阵列产生由具有高达8nm的线宽的多个单独波长构成的具有约20nm宽的预定总线宽的光辐射， 辐射的中心波长例如在阵列的工作温度的中心点处使用的激光增益材料的吸收带内。 该系统可以包括高反射平面镜，其具有放置在激光二极管阵列和激光增益材料之间的周期性传输片，发射片的尺寸使得最小的泵浦辐射损失。

    Method and Apparatus for Maximizing Publisher Revenue
    6.
    发明申请
    Method and Apparatus for Maximizing Publisher Revenue 有权
    最大化发布商收入的方法和设备

    公开(公告)号：US20110131099A1

    公开(公告)日：2011-06-02

    申请号：US12628958

    申请日：2009-12-01

    申请人： Tom Shields ,  C. Douglas Cosman ,  Craig Miller ,  John Barr

    发明人： Tom Shields ,  C. Douglas Cosman ,  Craig Miller ,  John Barr

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/02 ,  G06Q30/0275

    摘要： A computer implemented method for maximizing publisher revenue for online advertising is provided. The computer implemented method includes determining a ratio of guaranteed ad impressions to expected remaining ad impressions. If the ratio is less than a threshold, the method includes, identifying a minimum bid value, the minimum bid value based on the ratio; comparing the minimum bid value to a received bid value for an ad impression; allocating the ad impression to an owner of the received bid when the received bid value is greater than or equal to the minimum bid value; and displaying an ad of the owner of the received bid. If the ratio is greater than the threshold, the method includes, allocating the ad impression to an owner of the guaranteed ad impressions. In one embodiment, the method operations are stored on a computer readable storage medium.

    摘要翻译： 提供了一种最大化在线广告发布商收入的计算机实现方法。 计算机实现的方法包括确定有保证的广告展示与预期的剩余广告展示的比率。 如果所述比率小于阈值，则所述方法包括：基于所述比率识别最小出价值，所述最小出价值; 将最低出价值与广告展示的接收出价值进行比较; 当接收到的出价值大于或等于最低出价值时，将广告展示分配给收到的出价的所有者; 并显示收到的出价所有者的广告。 如果比率大于阈值，则该方法包括：将广告展示分配给保证广告展示的所有者。 在一个实施例中，方法操作被存储在计算机可读存储介质上。

    Implantable VAD with replaceable percutaneous cable
    8.
    发明授权
    Implantable VAD with replaceable percutaneous cable 有权
    可植入VAD与可更换的经皮电缆

    公开(公告)号：US08382830B2

    公开(公告)日：2013-02-26

    申请号：US12602926

    申请日：2008-06-06

    申请人： Tim Maher ,  Jim Lee ,  Ron Ness ,  Herb Chen ,  Jesse Hubbard ,  Phillip J. Miller ,  John Barr ,  James W. Long ,  Karl Nelson

    发明人： Tim Maher ,  Jim Lee ,  Ron Ness ,  Herb Chen ,  Jesse Hubbard ,  Phillip J. Miller ,  John Barr ,  James W. Long ,  Karl Nelson

    IPC分类号： A61M1/10

    CPC分类号： A61M39/0247 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/107 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  A61M2039/0258 ,  A61M2039/0273

    摘要： There are disclosed apparatus and methods for replacing a percutaneous cable in connection with a vascular device. In an embodiment, the apparatus includes a distal disconnect coupler, a distal connector portion of the cable configured for removable connection with the distal disconnect coupler, and a connector cap configured for removable connection with the distal disconnect coupler and for tunneling through skin and tissue. In one embodiment, a method of repositioning a percutaneous cable in connection with a vascular device includes providing the cable with a distal disconnect coupler, disconnecting the cable at the distal disconnect coupler, attaching a connector cap to the distal disconnect coupler, removing the percutaneous cable from a first exit site, tunneling the connector cap together with the distal disconnect coupler through skin and tissue to form a new exit site, disconnecting the connector cap, and connecting the cable to the distal disconnect coupler.

    摘要翻译： 公开了与血管装置相关地替换经皮电缆的装置和方法。 在一个实施例中，所述装置包括远端断开联接器，所述电缆的远端连接器部分被构造成用于与所述远端断开连接器的可移除连接，以及连接器帽，所述连接器帽被配置为可移除地与所述远端断开连接器连接并且用于穿透皮肤和组织。 在一个实施例中，重新定位与血管装置相关联的经皮电缆的方法包括：将电缆提供远端断开耦合器，在远端断开耦合器处断开电缆，将连接器盖连接到远端断开耦合器，去除经皮电缆 从第一出口部位，通过皮肤和组织将连接器帽与远端断开连接器一起穿透，以形成新的出口部位，断开连接器盖并将电缆连接到远端断开连接器。

    Silicone coating composition for protection from cathodic stress
    10.
    发明申请
    Silicone coating composition for protection from cathodic stress 审中-公开
    用于保护阴极应力的硅酮涂料组合物

    公开(公告)号：US20070232749A1

    公开(公告)日：2007-10-04

    申请号：US11375211

    申请日：2006-03-15

    申请人： Farooq Ahmed ,  Faisal Huda ,  Seraj ul Huda ,  John Barr

    发明人： Farooq Ahmed ,  Faisal Huda ,  Seraj ul Huda ,  John Barr

    IPC分类号： C08L83/04 ,  B05D3/00 ,  B32B27/00

    CPC分类号： C09D5/10 ,  C08K3/10 ,  C08K5/544 ,  C08K9/06 ,  C09D183/04

    摘要： This invention relates to a corrosion protection silicone coating system provides for easy and convenient application by conventional methods such as dipping, brushing or spraying. The coating provides a guard against environmental effects causing cathodic stress along with high physical strength and adhesion achieved with a suitable blend of reinforcing and extending fillers. The coating is an organopolysiloxane rubber coating composition containing between about 10 and 80 weight percent of a sacrificial metal filler to provide protection against environmental effects causing cathodic stress. Preferably, the coating is a one-part room temperature vulcanizing organopolysiloxane rubber coating composition to provide protection against cathodic stress. The present invention also provides for a method of coating metal surfaces to protect the metal surface from corrosion and cathodic stress. The method comprises applying to the surface a thin layer of the above one-part organopolysiloxane rubber composition and allowing the layer of the one-part organopolysiloxane rubber composition to cure at room temperature to a silicone elastomer.

    摘要翻译： 本发明涉及防腐硅氧烷涂层系统，其通过常规方法如浸渍，刷涂或喷涂方便地应用。 涂层提供防止产生阴极应力的环境影响的保护，同时具有通过增强和延伸填料的合适混合物实现的高物理强度和粘合力。 该涂层是含有约10至80重量％的牺牲金属填料的有机聚硅氧烷橡胶涂料组合物，以提供防止引起阴极应力的环境影响的保护。 优选地，涂层是一部分室温硫化有机聚硅氧烷橡胶涂料组合物，以提供防止阴极应力的保护。 本发明还提供一种涂覆金属表面以保护金属表面免受腐蚀和阴极应力的方法。 该方法包括将上述一部分有机基聚硅氧烷橡胶组合物的薄层施加到表面上，并允许一部分有机聚硅氧烷橡胶组合物的层在室温下固化成硅氧烷弹性体。