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公开(公告)号：US07541373B2
公开(公告)日：2009-06-02
申请号：US11365534
申请日：2006-03-01
申请人： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen , Jesper Lau
发明人： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen , Jesper Lau
IPC分类号： A61K31/426 , C07D277/38
CPC分类号： C07D213/75 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译： 本发明涉及作为葡萄糖激酶活化剂的芳基羰基衍生物，其可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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公开(公告)号：US08063081B2
公开(公告)日：2011-11-22
申请号：US11981997
申请日：2007-10-31
申请人： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Maria Carmen Valcarce Lopez , Niels Blume , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
发明人： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Maria Carmen Valcarce Lopez , Niels Blume , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
IPC分类号： A61K31/425 , A61K31/44 , C07D277/04 , C07D211/72
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译： 本发明涉及作为葡萄糖激酶活化剂的芳基羰基衍生物，其可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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公开(公告)号：US07384967B2
公开(公告)日：2008-06-10
申请号：US10679887
申请日：2003-10-06
申请人： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
发明人： Dharma Rao Polisetti , Janos Tibor Kodra , Jesper Lau , Paw Bloch , Mustafa Guzel , Kalpathy Chidambareswaran Santhosh , Adnan M. M. Mjalli , Robert Carl Andrews , Govindan Subramanian , Michael Ankersen , Per Vedso , Anthony Murray , Lone Jeppesen
IPC分类号： A61K31/425 , A61K31/44 , C07D277/04 , C07D211/72
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
摘要翻译： 本发明涉及作为葡萄糖激酶活化剂的芳基羰基衍生物，其可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。
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4.发明授权N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes 有权N-杂芳基吲哚羧酰胺及其类似物，用作糖尿病治疗中的葡糖激酶活化剂公开(公告)号：US08148413B2
公开(公告)日：2012-04-03
申请号：US12895761
申请日：2010-09-30
申请人： Jesper Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
发明人： Jesper Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
摘要： This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherein A and B are further defined in the application.
摘要翻译： 本发明涉及作为葡萄糖激酶活化剂的化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。 所述化合物具有通式（I），其中A和B在本申请中进一步定义。
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5.发明授权N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes 失效N-杂芳基吲哚羧酰胺及其类似物，用作糖尿病治疗中的葡糖激酶活化剂公开(公告)号：US07812043B2
公开(公告)日：2010-10-12
申请号：US11439820
申请日：2006-05-24
申请人： Jesper F Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
发明人： Jesper F Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
摘要： This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherein A and B are further defined in the application.
摘要翻译： 本发明涉及作为葡萄糖激酶活化剂的化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。 所述化合物具有通式（I），其中A和B在本申请中进一步定义。
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6.发明申请N-HETEROARYL INDOLE CARBOXAMIDES AND ANALOGUES THEREOF, FOR USE AS GLUCOKINASE ACTIVATORS IN THE TREATMENT OF DIABETES 有权N-羟基吲哚类化合物及其类似物，用作治疗糖尿病的糖尿病激活剂公开(公告)号：US20110082144A1
公开(公告)日：2011-04-07
申请号：US12895761
申请日：2010-09-30
申请人： Jesper F. Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
发明人： Jesper F. Lau , Per Vedsø , János Tibor Kodra , Anthony Murray , Lone Jeppesen , Michael Ankersen , Govindan Subramanian , Adnan M. M. Mjalli , Robert Carl Andrews , Dharma Rao Polisetti , Daniel Peter Christen
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/427 , C07D471/04 , A61K31/437 , C07D403/14 , A61K31/506 , C07D401/14 , A61K31/4439 , C07D413/14 , A61P3/10
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D491/04
摘要： This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) wherein A and B are further defined in the application.
摘要翻译： 本发明涉及作为葡萄糖激酶活化剂的化合物，因此可用于治疗，治疗，控制或辅助治疗疾病，其中增加葡糖激酶活性是有益的。 所述化合物具有通式（I），其中A和B在本申请中进一步定义。
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7.发明申请Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof 有权取代的熔融咪唑衍生物，药物组合物及其使用方法公开(公告)号：US20110201604A1
公开(公告)日：2011-08-18
申请号：US13028406
申请日：2011-02-16
申请人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
IPC分类号： A61K31/428 , C07D417/12 , C07D417/14 , A61K31/5377 , C07D471/04 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/541 , A61K31/506 , A61P11/00 , A61P1/16 , A61P31/12 , A61P17/06 , A61P17/00 , A61P25/28 , A61P25/16 , A61P9/12 , A61P9/00 , A61P7/02 , A61P29/00 , A61P11/06 , A61P13/12 , A61P27/02 , A61P3/10 , A61P3/04 , A61P35/00
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/4188 , A61K31/428 , A61K31/437 , C07D235/30 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供取代的稠合咪唑衍生物，其制备方法，包含取代的稠合咪唑衍生物的药物组合物和用于治疗炎症的方法。 取代的稠合咪唑衍生物可以控制血红素氧合酶的活性或活性和量的量。
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8.发明授权Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof 有权取代的稠合咪唑衍生物，药物组合物及其使用方法公开(公告)号：US08759535B2
公开(公告)日：2014-06-24
申请号：US13028406
申请日：2011-02-16
申请人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
IPC分类号： C07D417/12 , C07D235/30 , C07D513/04 , A61K31/437 , A61K31/428 , A61K31/4188 , A61K31/4168
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/4188 , A61K31/428 , A61K31/437 , C07D235/30 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供取代的稠合咪唑衍生物，其制备方法，包含取代的稠合咪唑衍生物的药物组合物和用于治疗炎症的方法。 取代的稠合咪唑衍生物可以控制血红素氧合酶的活性或活性和量的量。
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9.发明授权公开(公告)号：US08383644B2
公开(公告)日：2013-02-26
申请号：US12825631
申请日：2010-06-29
申请人： Adnan M. M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L. R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
发明人： Adnan M. M. Mjalli , Christopher Behme , Daniel P. Christen , Devi Reddy Gohimukkula , Dharma Rao Polisetti , James Quada , Jennifer L. R. Freeman , Kalpathy Santhosh , Muralidhar Bondlela , Mustafa Guzel , Ravindra Reddy Yarragunta , Robert Carl Andrews , Stephen Thomas Davis , Thomas Scott Yokum
IPC分类号： C07D491/056 , A61K31/436
CPC分类号： C07D491/056 , C07D319/20 , C07D491/06
摘要： The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.
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10.发明授权Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US08853226B2
公开(公告)日：2014-10-07
申请号：US13040382
申请日：2011-03-04
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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