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1.发明授权Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof 有权取代的稠合咪唑衍生物，药物组合物及其使用方法公开(公告)号：US08759535B2
公开(公告)日：2014-06-24
申请号：US13028406
申请日：2011-02-16
申请人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
IPC分类号： C07D417/12 , C07D235/30 , C07D513/04 , A61K31/437 , A61K31/428 , A61K31/4188 , A61K31/4168
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/4188 , A61K31/428 , A61K31/437 , C07D235/30 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供取代的稠合咪唑衍生物，其制备方法，包含取代的稠合咪唑衍生物的药物组合物和用于治疗炎症的方法。 取代的稠合咪唑衍生物可以控制血红素氧合酶的活性或活性和量的量。
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2.发明申请Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof 有权取代的熔融咪唑衍生物，药物组合物及其使用方法公开(公告)号：US20110201604A1
公开(公告)日：2011-08-18
申请号：US13028406
申请日：2011-02-16
申请人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
IPC分类号： A61K31/428 , C07D417/12 , C07D417/14 , A61K31/5377 , C07D471/04 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/541 , A61K31/506 , A61P11/00 , A61P1/16 , A61P31/12 , A61P17/06 , A61P17/00 , A61P25/28 , A61P25/16 , A61P9/12 , A61P9/00 , A61P7/02 , A61P29/00 , A61P11/06 , A61P13/12 , A61P27/02 , A61P3/10 , A61P3/04 , A61P35/00
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/4188 , A61K31/428 , A61K31/437 , C07D235/30 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供取代的稠合咪唑衍生物，其制备方法，包含取代的稠合咪唑衍生物的药物组合物和用于治疗炎症的方法。 取代的稠合咪唑衍生物可以控制血红素氧合酶的活性或活性和量的量。
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3.发明授权Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US08853226B2
公开(公告)日：2014-10-07
申请号：US13040382
申请日：2011-03-04
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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4.发明申请Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US20120172381A1
公开(公告)日：2012-07-05
申请号：US13410628
申请日：2012-03-02
IPC分类号： A61K31/519 , A61P11/06
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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5.发明授权Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors 有权三环化合物作为TNF-α合成的调节剂和PDE4抑制剂公开(公告)号：US08329715B2
公开(公告)日：2012-12-11
申请号：US13410628
申请日：2012-03-02
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/519 , C07D471/04 , Y02A50/411
摘要： The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.
摘要翻译： 本发明涉及式（I）的化合物如本文所定义，药物组合物和用于治疗由TNF-α或PDE4介导的病症或病症的方法，包括但不限于类风湿性关节炎。
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6.发明申请SUBSTITUTED PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE TO TREAT OXIDATIVE STRESS 审中-公开取代的吡啶衍生物，药物组合物和用于治疗氧化应激的方法公开(公告)号：US20120071505A1
公开(公告)日：2012-03-22
申请号：US13278515
申请日：2011-10-21
IPC分类号： A61K31/47 , C07D215/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P3/10 , A61P13/12 , A61P25/28 , A61P25/16 , A61P25/00 , A61P11/06 , A61P11/00 , A61P17/00 , A61P27/02 , A61P27/12 , A61P35/00 , C07D215/54
CPC分类号： A61K31/443 , A61K31/44
摘要： Substituted pyridine derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted pyridine derivative, and methods of use in treating inflammation are provided. The substituted pyridine derivatives may control of the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供了取代的吡啶衍生物，其制备方法，包含取代的吡啶衍生物的药物组合物和用于治疗炎症的方法。 取代的吡啶衍生物可以控制血红素加氧酶的活性或活性和量的量。
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公开(公告)号：US06838291B2
公开(公告)日：2005-01-04
申请号：US09904045
申请日：2001-07-12
申请人： John W. Butcher , David A. Claremon , Thomas M. Connolly , Jerzy Karczewski , Kenneth S. Koblan , Matthew J. Kostura , Nigel J. Liverton , Dennis C. Dean , David G. Melillo
发明人： John W. Butcher , David A. Claremon , Thomas M. Connolly , Jerzy Karczewski , Kenneth S. Koblan , Matthew J. Kostura , Nigel J. Liverton , Dennis C. Dean , David G. Melillo
IPC分类号： G01N33/566 , A61K51/04 , C07D491/10 , C07D491/107 , C07D491/20 , C07F7/18 , C12N15/09 , C12Q1/02 , G01N33/58 , G01N33/60 , G01N33/68 , G01N33/534 , G01N33/567
CPC分类号： G01N33/6872 , A61K51/0455 , A61K51/0476 , C07B2200/05 , C07D491/10 , C07F7/1804 , G01N33/60
摘要： The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1′-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4′-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.
摘要翻译： 本发明涉及放射性配体化合物[35 S] - 放射性标记的（+） - N- [1' - （6-氰基-1,2,3,4-四氢-2（R） - 萘基） -3,4-二氢-4（R） - 氧代氧杂螺[2H-1-苯并吡喃-2,4'-哌啶] -6-基]甲磺酰胺。 本发明的范围也是用于鉴定结合IKr通道的化合物的方法，并且可能具有抗心律失常活性。
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