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公开(公告)号：US20100256138A1
公开(公告)日：2010-10-07
申请号：US12814964
申请日：2010-06-14
申请人： Dizhong Chen , Hong Y. Song , Eric T. Sun , Niefang Yu , Yong Zou
发明人： Dizhong Chen , Hong Y. Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/454 , A61K31/4439 , A61P37/00 , A61P35/00 , A61P33/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P9/00
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地说，本发明涉及含苯并咪唑的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及涉及组蛋白脱乙酰酶（HDAC）的调节异常或与其相关的其它疾病的药物。
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公开(公告)号：US07781595B2
公开(公告)日：2010-08-24
申请号：US10572958
申请日：2004-09-21
申请人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/5377 , C07D235/06 , C07D401/06 , C07D401/04 , C07D413/06
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地说，本发明涉及含苯并咪唑的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及涉及组蛋白脱乙酰酶（HDAC）的调节异常或与其相关的其它疾病的药物。
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公开(公告)号：US08551988B2
公开(公告)日：2013-10-08
申请号：US12814964
申请日：2010-06-14
申请人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
发明人： DiZhong Chen , Hong Yan Song , Eric T. Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/535 , A61K31/44 , C07D235/00 , C07D413/00 , C07D401/00
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
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公开(公告)号：US08143282B2
公开(公告)日：2012-03-27
申请号：US12065989
申请日：2006-08-01
申请人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
发明人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
IPC分类号： C07D401/04 , C07D235/14 , A61K31/4184 , A61K31/454 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D235/08 , C07D235/06 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D401/04 , C07D403/04
摘要： The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的化合物。 更具体地说，本发明涉及杂环化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或伴随其它疾病的其它疾病的药物。
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公开(公告)号：US20090048300A1
公开(公告)日：2009-02-19
申请号：US12065989
申请日：2006-08-01
申请人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
发明人： Dizhong Chen , Weiping Deng , Ken C. Lee , Pek L. Lye , Eric T. Sun , Haishan Wang , Niefang Yu
IPC分类号： C07D401/04 , C07D235/14 , A61K31/4184 , A61K31/454 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D235/08 , C07D235/06 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D401/04 , C07D403/04
摘要： The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的化合物。 更具体地说，本发明涉及杂环化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或伴随其它疾病的其它疾病的药物。
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公开(公告)号：US20070043043A1
公开(公告)日：2007-02-22
申请号：US10572958
申请日：2004-09-21
申请人： Dizhong Chen , Weiping Deng , Kanda Sangthongpitag , Hong Song , Eric Sun , Niefang Yu , Yong Zou
发明人： Dizhong Chen , Weiping Deng , Kanda Sangthongpitag , Hong Song , Eric Sun , Niefang Yu , Yong Zou
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/4184 , C07D413/02 , C07D403/02
CPC分类号： A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , C04B35/632 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/02 , C07D403/06 , C07D409/04 , C07D413/02 , G01N33/5011 , G01N33/6875 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地说，本发明涉及含苯并咪唑的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及涉及组蛋白脱乙酰酶（HDAC）的调节异常或与其相关的其它疾病的药物。
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7.发明授权公开(公告)号：US08921424B2
公开(公告)日：2014-12-30
申请号：US12739635
申请日：2008-10-27
申请人： Niefang Yu , Xiaoyu Liu , Xiaodong Hu
发明人： Niefang Yu , Xiaoyu Liu , Xiaodong Hu
IPC分类号： A61K31/195 , A61K31/192 , C07C259/04 , C07C323/63 , C07D333/20 , C07D213/53 , C07C311/07 , C07C275/42 , C07C335/22 , C07C259/06
CPC分类号： C07C323/63 , C07C259/06 , C07C275/42 , C07C311/07 , C07C335/22 , C07D213/53 , C07D333/20
摘要： The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and the composition comprising the same may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译： 本发明涉及由式（I）表示的化合物或包含至少一种这样的化合物的组合物，其是组蛋白脱乙酰酶的抑制剂。 这些化合物的详细描述在说明书中公开。 这些化合物和包含其的组合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或与之相关的其它疾病。
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8.发明申请NOVEL HISTONE DEACETYLASE INHIBITORS, PROCESS FOR PREPARATION AND USES THEREOF 有权新型HISTONE脱乙酰酶抑制剂，其制备方法及其用途公开(公告)号：US20110218221A1
公开(公告)日：2011-09-08
申请号：US12739635
申请日：2008-10-27
申请人： Niefang Yu , Xiaoyu Liu , Xiaodong Hu
发明人： Niefang Yu , Xiaoyu Liu , Xiaodong Hu
IPC分类号： A61K31/4402 , C07C259/06 , C07D333/24 , C07D213/54 , C07D333/38 , C07D213/81 , A61K31/165 , A61K31/381 , A61P35/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P25/08 , A61P21/00 , A61P3/10 , A61P27/06 , A61P27/02 , A61P29/00 , A61P19/02 , A61P17/06 , A61P11/06 , A61P25/18 , A61P25/24 , A61P9/04 , A61P9/10 , A61P1/16 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/22 , A61P33/02 , A61P33/06 , A61P7/06
CPC分类号： C07C323/63 , C07C259/06 , C07C275/42 , C07C311/07 , C07C335/22 , C07D213/53 , C07D333/20
摘要： The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and the composition comprising the same may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
摘要翻译： 本发明涉及由式（I）表示的化合物或包含至少一种这样的化合物的组合物，其是组蛋白脱乙酰酶的抑制剂。 这些化合物的详细描述在说明书中公开。 这些化合物和包含其的组合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶（HDAC）活性的酶有关或与之相关的其它疾病。
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