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    IMMUNOGENIC COMPOSITIONS FOR STREPTOCOCCUS AGALACTIAE
    7.
    发明申请
    IMMUNOGENIC COMPOSITIONS FOR STREPTOCOCCUS AGALACTIAE 审中-公开
    用于结核分枝杆菌的免疫组化

    公开(公告)号：US20100015168A1

    公开(公告)日：2010-01-21

    申请号：US12303999

    申请日：2007-06-11

    申请人： Domenico Maione ,  Guido Grandi ,  Nathalie Norais

    发明人： Domenico Maione ,  Guido Grandi ,  Nathalie Norais

    IPC分类号： A61K39/00 ,  G01N33/53 ,  C12N15/63 ,  C07K14/00 ,  C07H21/04

    CPC分类号： A61K39/092 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/315 ,  G01N33/56944 ,  G01N2469/20

    摘要： The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae (“GBS”) protein GBS 80 and their use as prophylactic, diagnostic and therapeutic compositions. The invention also provides nucleic acids encoding the immunogenic polypeptides. Also provided are vectors useful for making such immunogenic polypeptides and host cells transformed with such vectors. In particular, the invention relates to a group immunogenic polypeptides derived from GBS 80. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other GBS antigens to provide therapeutic compositions with broader range. In addition, the immunogenic polypeptides may also include flanking portions of the GBS 80 protein.

    摘要翻译： 本发明涉及源自无乳链球菌（GBS）蛋白GBS 80中的表位的免疫原性多肽及其作为预防，诊断和治疗组合物的用途。 本发明还提供编码免疫原性多肽的核酸。 还提供了可用于制备这种免疫原性多肽的载体和用这些载体转化的宿主细胞。 特别地，本发明涉及衍生自GBS80的组免疫原性多肽。组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。 例如，免疫原性多肽可以与其他GBS抗原组合以提供更宽范围的治疗组合物。 此外，免疫原性多肽还可以包括GBS 80蛋白的侧翼部分。

    Immunogenic Compositions for Streptococcus Agalactiae
    9.
    发明申请
    Immunogenic Compositions for Streptococcus Agalactiae 有权
    无乳链球菌的免疫原性组成

    公开(公告)号：US20080220010A1

    公开(公告)日：2008-09-11

    申请号：US10568422

    申请日：2004-09-15

    申请人： John L. Telford ,  Guido Grandi ,  Immaculada Margarit Y Ros ,  Domenico Maione

    发明人： John L. Telford ,  Guido Grandi ,  Immaculada Margarit Y Ros ,  Domenico Maione

    IPC分类号： A61K39/02 ,  A61K39/09 ,  A61K39/00

    CPC分类号： A61K39/09 ,  Y10S530/825

    摘要： This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.

    摘要翻译： 本申请涉及包含GBS多肽抗原组合的B组链球菌（“GBS”）疫苗，其中多肽有助于接受者的免疫应答。 优选地，本发明的组合物包含两种或更多种GBS抗原的组合，其中所述组合包括GBS 80或其片段。 在一个实施方案中，该组合可以由选自GBS 80，GBS 91，GBS 104，GBS 184，GBS 276，GBS 305，GBS 322，GBS 330，GBS 338，GBS 361的抗原组中的两至十三个GBS抗原组成 ，GBS 404，GBS 690和GBS 691。