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1.发明申请MUCOADHESIVE BUCCAL TABLETS FOR THE TREATMENT OF OROFACIAL HERPES 审中-公开用于治疗异位睾丸的MUCOADHESIVE BUCCAL PABLETS公开(公告)号：US20130210841A1
公开(公告)日：2013-08-15
申请号：US13514594
申请日：2010-12-09
IPC分类号： A61K9/00 , A61K31/522
CPC分类号： A61K9/006 , A61K9/2054 , A61K9/2063 , A61K31/44 , A61K31/522
摘要： The present invention relates to the treatment and/or prevention of muco-cutaneous herpes simplex virus diseases using prolonged release mucoadhesive buccal tablets comprising an acyclic guanosine antiviral agent. These tablets are particularly-suitable for the treatment and/or prevention of orofacial herpes.
摘要翻译： 本发明涉及使用包含非循环鸟苷抗病毒剂的延长释放粘膜粘连性颊含药片治疗和/或预防粘膜皮肤单纯疱疹病毒病。 这些片剂特别适用于治疗和/或预防口腔疱疹。
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公开(公告)号：US08747896B2
公开(公告)日：2014-06-10
申请号：US13565653
申请日：2012-08-02
CPC分类号： A61K47/38 , A61K9/0056 , A61K9/006 , A61K9/2027 , A61K9/2063 , A61K31/4178 , A61K31/4468 , A61K31/522
摘要： A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation.
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公开(公告)号：US08592434B2
公开(公告)日：2013-11-26
申请号：US12634225
申请日：2009-12-09
IPC分类号： A01N43/90 , A01N43/42 , A61K31/522 , A61K31/44
CPC分类号： A61K31/522 , A61K9/006 , A61K9/2054
摘要： The present invention relates to the treatment or prevention of mucocutaneous herpes simplex virus diseases using prolonged release mucoadhesive buccal tablets comprising an acyclic guanosine antiviral agent. These tablets are particularly suitable for the treatment or prevention of orofacial herpes.
摘要翻译： 本发明涉及使用包含非循环鸟苷抗病毒剂的延长释放粘膜粘连性颊片来治疗或预防粘膜皮肤单纯疱疹病毒病。 这些片剂特别适用于治疗或预防口腔疱疹。
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4.发明申请MUCOSAL BIOADHESIVE SLOW RELEASE CARRIER FOR DELIVERING ACTIVE PRINCIPLES 有权MUCOSAL BIOADHESIVE SLOW RELEASE CARRIER FOR DELLERING ACTIVE PRINCIPLES公开(公告)号：US20100266667A1
公开(公告)日：2010-10-21
申请号：US12707369
申请日：2010-02-17
CPC分类号： A61K47/38 , A61K9/0056 , A61K9/006 , A61K9/2027 , A61K9/2063 , A61K31/4178 , A61K31/4468 , A61K31/522
摘要： A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation.
摘要翻译： 粘膜生物粘附缓释载体，其包含活性成分并且没有淀粉，乳糖，其能够释放活性成分持续超过20小时。 该生物粘附载体包含稀释剂，碱金属烷基硫酸盐，结合剂，至少一种生物粘附聚合物和至少一种缓释聚合物，以及其制备方法。
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5.发明授权公开(公告)号：US08211466B2
公开(公告)日：2012-07-03
申请号：US12707369
申请日：2010-02-17
CPC分类号： A61K47/38 , A61K9/0056 , A61K9/006 , A61K9/2027 , A61K9/2063 , A61K31/4178 , A61K31/4468 , A61K31/522
摘要： A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation.
摘要翻译： 粘膜生物粘附缓释载体，其包含活性成分并且没有淀粉，乳糖，其能够释放活性成分持续超过20小时。 该生物粘附载体包含稀释剂，碱金属烷基硫酸盐，结合剂，至少一种生物粘附聚合物和至少一种缓释聚合物，以及其制备方法。
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6.发明申请Mucosal Bioadhesive SLow Release Carrier for Delivering Active Principles 审中-公开粘膜生物粘合剂SLow释放载体提供主动原则公开(公告)号：US20090169511A1
公开(公告)日：2009-07-02
申请号：US12225470
申请日：2007-03-23
IPC分类号： A61K47/42 , A61K47/36 , A61K47/32 , A61K31/52 , A61K31/7072 , A61K31/662 , A61K31/708 , A61K31/13 , A61K38/21 , A61P31/12 , A61K47/38
CPC分类号： A61K47/38 , A61K9/0056 , A61K9/006 , A61K9/2027 , A61K9/2063 , A61K31/4178 , A61K31/4468 , A61K31/522
摘要： A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation.
摘要翻译： 粘膜生物粘附缓释载体，其包含活性成分并且没有淀粉，乳糖，其能够释放活性成分持续超过20小时。 该生物粘附载体包含稀释剂，碱金属烷基硫酸盐，结合剂，至少一种生物粘附聚合物和至少一种缓释聚合物，以及其制备方法。
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公开(公告)号：US20110237563A1
公开(公告)日：2011-09-29
申请号：US12729735
申请日：2010-03-23
申请人： Dominique Costantini
发明人： Dominique Costantini
IPC分类号： A61K31/445 , A61K31/4178 , A61K31/454 , A61K31/5517 , A61K31/519 , A61K31/221 , A61K31/53 , A61K31/55 , A61K31/195 , A61K31/485 , A61K31/551 , A61K31/404 , A61K31/4196 , A61K31/422 , A61K31/4025 , A61K31/403 , A61K31/495 , A61K31/435 , A61K31/135 , A61K31/375 , A61K31/57 , A61K31/522 , A61K31/573 , A61K31/4535 , A61K31/451 , A61K31/13 , A61K31/5415 , A61K31/4164 , A61P43/00
CPC分类号： A61K31/13 , A61K9/006 , A61K31/135 , A61K31/195 , A61K31/221 , A61K31/375 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4164 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/435 , A61K31/445 , A61K31/451 , A61K31/4535 , A61K31/454 , A61K31/485 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5517 , A61K31/57 , A61K31/573
摘要： The present invention related to the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with critical buccal condition, leading to difficulties in swallowing oral medicine forms and thus difficulties in treating said illnesses. Particularly, the present invention discloses the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with dysphagia and/or odynophagia and/or aspiration risk. Another aspect of the present invention is the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for the treatment of dysphagia and/or odynophagia and/or aspiration risk.
摘要翻译： 本发明涉及通过口服快速分散/溶解药物递送系统施用生物活性剂，用于治疗患有关键口腔病症的患者的疾病，导致吞咽口服药物形式困难，因此难以治疗所述疾病。 特别地，本发明公开了通过口服快速分散/溶解药物递送系统来施用生物活性剂，用于治疗患有吞咽困难和/或odynophagia和/或吸入风险的患者的疾病。 本发明的另一方面是通过口服快速分散/溶解药物递送系统来施用生物活性剂以治疗吞咽困难和/或食欲不全和/或吸入风险。
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公开(公告)号：US07651698B2
公开(公告)日：2010-01-26
申请号：US11113072
申请日：2005-04-25
CPC分类号： A61K47/20 , A61K9/006 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K9/2013 , A61K9/2063 , A61K9/2077 , A61K31/4174 , A61K31/445 , A61K31/4468 , A61K31/485 , A61K31/522 , A61K31/551 , A61K31/7072 , A61K45/06
摘要： The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active principle dissolution test of more than 70% over 8 hours and to a method for its preparation. This bioadhesive therapeutic system comprises quantities of natural proteins representing 50% by weight of active principle and at least 20% by weight of said tablet, between 10% and 20% of a hydrophilic polymer, and compression excipients, and comprising between 4% and 10% of an alkali metal alkylsulphate to reinforce the local availability of active principle and between 0.1% and 1% of a monohydrate sugar.
摘要翻译： 本发明涉及含有至少一种活性成分的延长释放的生物粘附性粘膜治疗系统，其具有超过70％的8小时的主动溶解试验及其制备方法。 该生物粘附性治疗系统包含代表活性成分的50重量％和所述片剂的至少20重量％，亲水性聚合物的10％至20％的压缩赋形剂和包含4％至10％的天然蛋白质 ％的碱金属烷基硫酸盐以增强活性成分的局部可用性和0.1％至1％的一水合物糖。
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公开(公告)号：US20050208129A1
公开(公告)日：2005-09-22
申请号：US11113072
申请日：2005-04-25
IPC分类号： A61K9/70 , A61K9/00 , A61K9/20 , A61K9/22 , A61K31/4174 , A61K31/4468 , A61K31/7048 , A61K31/7064 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/42 , A61P1/02 , A61P13/00 , A61P17/00 , A61P25/04 , A61P29/00 , A61P29/02 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/14 , A61P31/18 , A61P35/00 , A61K38/00 , A61K31/4178 , A61K31/4196 , A61K31/496
CPC分类号： A61K47/20 , A61K9/006 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K9/2013 , A61K9/2063 , A61K9/2077 , A61K31/4174 , A61K31/445 , A61K31/4468 , A61K31/485 , A61K31/522 , A61K31/551 , A61K31/7072 , A61K45/06
摘要： The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active principle dissolution test of more than 70% over 8 hours and to a method for its preparation. Said bioadhesive therapeutic system comprises quantities of natural proteins representing at least 50% by weight of active principle and at least 20% by weight of said tablet, between 10% and 20% of a hydrophilic polymer, and compression excipients, and comprising between 4% and 10% of an alkali metal alkylsulphate to reinforce the local availability of active principle and between 0.1% and 1% of a monohydrate sugar.
摘要翻译： 本发明涉及含有至少一种活性成分的延长释放的生物粘附性粘膜治疗系统，其具有超过70％的8小时的主动溶解试验及其制备方法。 所述生物粘附性治疗系统包含代表活性成分的至少50重量％和所述片剂的至少20重量％，亲水性聚合物的10至20重量％的压缩赋形剂和包含4重量％ 和10％的碱金属烷基硫酸盐，以增强活性成分的局部可用性和0.1％至1％的一水合糖。
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10.发明申请Synergic Combinations Comprising a Quinoline Compound and Other Hiv Infection Therapeutic Agents 审中-公开喹啉化合物和其他感染治疗剂的协同组合公开(公告)号：US20080280849A1
公开(公告)日：2008-11-13
申请号：US11915786
申请日：2005-06-01
申请人： Herve Leh , Fatima Zouhiri , Jean-Francois Mouscadet , Claire-Marie Thomas , Elisabeth Dam , Dominique Costantini
发明人： Herve Leh , Fatima Zouhiri , Jean-Francois Mouscadet , Claire-Marie Thomas , Elisabeth Dam , Dominique Costantini
IPC分类号： A61K31/47 , A61K31/7064 , A61K31/52 , A61K31/708 , A61K31/7068 , A61K31/513 , A61K31/7072 , A61K31/675 , A61K31/496 , A61K31/538 , A61K31/551 , A61K31/472 , A61P31/18 , C07D215/00
CPC分类号： C07D215/26 , A61K31/402 , A61K31/47 , A61K31/506 , A61K31/551 , A61K45/06 , C07D215/48 , A61K2300/00
摘要： The invention relates to a combination comprising a quinoline compound or its sail, according to general formula (I) and at least one HIV infection therapeutic agent selected from the group consisting of entry inhibitors, reverse-transcriptase inhibitors, strand-transfer inhibitors, protease inhibitors, and maturation inhibitors. Said combination has therapeutic synergy in the treatment of an HIV infection compared with the quinoline compound, or HIV infection therapeutic agent alone.
摘要翻译： 本发明涉及包含根据通式（I）的喹啉化合物或其帆的组合和至少一种选自入侵抑制剂，逆转录酶抑制剂，链转移抑制剂，蛋白酶抑制剂的HIV感染治疗剂 ，和成熟抑制剂。 与喹啉化合物或单独的HIV感染治疗剂相比，所述组合在治疗HIV感染中具有治疗协同作用。
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