Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea
    1.
    发明授权
    Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea 失效
    用于封闭环刺激人类舌下神经治疗阻塞性睡眠呼吸暂停的方法和装置

    公开(公告)号:US06587725B1

    公开(公告)日:2003-07-01

    申请号:US09744640

    申请日:2001-03-26

    IPC分类号: A61N118

    CPC分类号: A61N1/3601

    摘要: This invention is a fully implanted functional electrical stimulator (20) apparatus, a method for treatment of obstructive sleep apnea that provides for both reliable detection/prediction or airway occlusion that relieves, and/or prevents same by selective, direct electrical stimulation of the hypoglossal nerve (HG). The method, and apparatus sense hypoglossal nerve electro-neurogram activity for purposes of detecting or predicting obstructive sleep apnea. The sensed hypoglossal nerve activity, itself, is used to trigger functional electrical stimulation of the hypoglossal nerve in order to improve upper airway patency. Further, an improved hypoglossal nerve stimulation electrode (10) interface (IC) is provided that allows for simultaneous hypoglossal nerve activity sensing, and stimulation by eliminating stimulation artifacts that would otherwise trigger further erroneous stimulation.

    摘要翻译: 本发明是一种完全植入的功能性电刺激器(20)装置,一种治疗阻塞性睡眠呼吸暂停的方法,其提供可靠的检测/预测或气道闭塞,所述阻塞性睡眠呼吸暂停和/或通过选择性的直接电刺激舌下液 神经(HG)。 该方法和装置感测舌下神经电神经活动,用于检测或预测阻塞性睡眠呼吸暂停。 感觉舌下神经活动本身用于触发舌下神经的功能性电刺激,以改善上呼吸道通畅。 此外,提供了改进的舌下神经刺激电极(10)界面(IC),其允许同时舌下神经活动感测和通过消除否则将触发进一步错误刺激的刺激伪影的刺激。

    Athermal, optical-fiber device comprising an integrated component
    2.
    发明授权
    Athermal, optical-fiber device comprising an integrated component 失效
    包括集成组件的光热纤维装置

    公开(公告)号:US06839487B2

    公开(公告)日:2005-01-04

    申请号:US10098674

    申请日:2002-03-15

    摘要: The present invention relates to an optical-fiber device comprising at least one component (11) integrated into the fiber (10), and a support assembly on which the fiber (10) is fixed at two points (1322, 1332) situated respectively on either side of the integrated component (11), which support comprises at least two elements (120, 130, 132) possessing different thermal-expansion coefficients which are arranged functionally in series between the two points of fixing of the fiber, characterized in that the interface (131, 133) between the two elements (120, 130, 132) possessing different thermal-expansion coefficients is at least substantially perpendicular to the axis of the fiber (10), and in that the means for support of the optical fiber (10) comprise a support assembly consisting of three pieces (130, 120 and 132) arranged in series, in a Z-shaped geometry.

    Package for folding intraocular implants
    3.
    发明授权
    Package for folding intraocular implants 失效
    用于折叠眼内植入物的包装

    公开(公告)号:US5941390A

    公开(公告)日:1999-08-24

    申请号:US171060

    申请日:1998-10-09

    IPC分类号: A61F2/16 A61B17/00

    CPC分类号: A61F2/1691 A61F2/1664

    摘要: The invention relates to packaging for folding intraocular implants having a flexible optical portion. The packaging (70) comprises: a base (31); folding support means (30) for supporting the optical portion (24) and comprising a folding edge (34) substantially parallel to said base, which edge is suitable for coming into contact with a portion of the bottom face of the optical portion (24) and forms a longitudinal axis (32) enabling the implant to be folded along said folding axis (28) on either side of said folding edge (34); and positioning means (50; 56; 60) designed to co-operate with at least a portion of the peripheral zone (26) of the optical portion (24) to support the implant and to enable the folding axis (28) of the implant to be maintained in the same vertical plane as the longitudinal axis (32) of said fold support means (30).

    摘要翻译: PCT No.PCT / FR97 / 00717 Sec。 371日期:1998年10月9日 102(e)1998年10月9日PCT PCT 1997年4月22日PCT公布。 第WO97 / 39701号公报 日期1997年10月30日本发明涉及具有柔性光学部分的折叠眼内植入物的包装。 包装(70)包括:基座(31); 用于支撑光学部分(24)并且包括基本上平行于所述基部的折叠边缘(34)的折叠支撑装置(30),该边缘适合于与光学部分(24)的底面的一部分接触, 并且形成使所述植入物沿所述折叠边缘(34)的任一侧上的所述折叠轴线(28)折叠的纵向轴线(32)。 以及设计成与所述光学部分(24)的周边区域(26)的至少一部分配合以支撑所述植入物并且使所述植入物的折叠轴线(28)能够相互配合的定位装置(50; 56; 60) 保持在与所述折叠支撑装置(30)的纵向轴线(32)相同的垂直平面中。

    Method of treating obstructive sleep apnea using electrical nerve stimulation
    4.
    发明申请
    Method of treating obstructive sleep apnea using electrical nerve stimulation 有权
    使用电神经刺激治疗阻塞性睡眠呼吸暂停的方法

    公开(公告)号:US20060224211A1

    公开(公告)日:2006-10-05

    申请号:US11109338

    申请日:2005-04-19

    IPC分类号: A61N1/36

    摘要: A method for treating a medical condition, such as obstructive sleep apnea, includes the step of stimulating a nerve, particularly the hypoglossal nerve, using at least one of the following techniques: (a) continuous low-level electrical stimulation; (b) electrical stimulation synchronized with a physical process, such as inspiration, without feedback from the nerve being stimulated; and (c) intermittent electrical stimulation at controlled intervals based on the patient's metabolism.

    摘要翻译: 用于治疗诸如阻塞性睡眠呼吸暂停之类的医学病症的方法包括使用以下技术中的至少一种来刺激神经,特别是舌下神经的步骤:(a)连续的低水平电刺激; (b)与物理过程同步的电刺激,例如灵感,无刺激的神经的反馈; 和(c)基于患者代谢的受控间隔的间歇性电刺激。

    Flexible intraocular implant and set of such implants
    6.
    发明授权
    Flexible intraocular implant and set of such implants 失效
    灵活的眼内植入物和这种植入物的组合

    公开(公告)号:US6051025A

    公开(公告)日:2000-04-18

    申请号:US142685

    申请日:1998-09-11

    IPC分类号: A61F2/16 A61F2/14

    CPC分类号: A61F2/1616

    摘要: The invention relates to an intraocular implant made of a flexible material presenting an optical refractive index included between 1.40 and 1.56 including an optic portion (10) and a haptic portion, the optic portion generally being circular. The optic portion of the implant has a cylindrical circumferential surface (16) with a width e of 0.1-0.3 mm and a diameter De of 5-7 mm, and two main surfaces (12, 14), each consisting of a spherical cap (18) of which the geometrical axis coincides with the optical axis and a frusto-conical surface (20) with an inner edge connected to the edge of the spherical cap via a toroidal surface portion (22), and an outer edge connected to said circumferential surface, the thickness E of said optic portion being between 1 and 1.5 mm along the optical axis.

    摘要翻译: PCT No.PCT / FR97 / 00445 Sec。 371日期:1998年9月11日 102(e)1998年9月11日PCT PCT 1997年3月13日PCT公布。 出版物WO97 / 33536 日期:1997年9月18日本发明涉及一种由柔性材料制成的眼内植入物,其具有包括光学部分(10)和触觉部分在内的1.40至1.56之间的光学折射率,所述光学部分通常为圆形。 植入物的光学部分具有宽度e为0.1-0.3mm,直径De为5-7mm的圆柱形周向表面(16)和两个主表面(12,14),每个主表面由球形帽 18),其几何轴线与光轴重合,并且具有通过环形表面部分(22)连接到球形帽的边缘的内边缘的截头圆锥形表面(20),以及连接到所述圆周表面 表面,所述光学部分的厚度E沿着光轴在1和1.5mm之间。

    Scale turning device, notably for streamlined tractor rope comprising such scales
    7.
    发明授权
    Scale turning device, notably for streamlined tractor rope comprising such scales 有权
    标尺车削装置,特别是用于包括这种秤的流线型拖拉机绳索

    公开(公告)号:US08240267B2

    公开(公告)日:2012-08-14

    申请号:US12741823

    申请日:2008-11-06

    IPC分类号: B63B21/66

    CPC分类号: B63B21/663

    摘要: The present invention relates to a means for mutually aligning the scales of a rope streamlined by means of scales articulated to rotate about its axis, the alignment being necessary to enable such a rope to be wound onto the drum of a winch. It mainly consists of a device presenting a bevelled front face and comprising a cavity extending from front to rear, inside which passes the rope before it is wound. The cavity presents a longitudinal opening with two lateral edges, each edge following, from front to back, a profile in helical form, the two helices being coaxial to each other and with the axis of symmetry of the cavity. The wall of the cavity is also configured so as to follow the cross-sectional profile of the scale all along its path in the device. The device is arranged relative to the drum on which the rope is wound so that, given the length of the edges of the opening, regardless of the orientation of a scale on entering the device, the latter, on exiting, assumes the desired orientation, in the alignment of the adjacent scales. The invention applies notably to the systems for handling tractor ropes streamlined by means of scales, used on a ship to pull a submersible body cast off at sea.

    摘要翻译: 本发明涉及一种用于相互对准通过铰链流动的绳索的绳索相对于其轴线旋转的装置,所述对准是使得这种绳索能够卷绕在绞盘的滚筒上所必需的。 它主要由具有斜面前表面的装置组成,包括从前到后延伸的腔体,其内部在绳索缠绕之前通过绳索。 空腔具有两个横向边缘的纵向开口,每个边缘从前到后依次为螺旋形轮廓,两个螺旋彼此同轴并且与空腔的对称轴线相同。 空腔的壁也被构造成沿着其在设备中的路径跟随标尺的横截面轮廓。 设备相对于缠绕绳索的滚筒布置,使得在给定开口的边缘的长度的情况下,无论标尺进入设备的方向如何,后者在退出时呈现期望的取向, 在相邻尺度的对齐中。 本发明特别适用于用于处理通过水垢流线化的拖拉机绳索的系统,用于在船上拉动在海上抛出的潜水体。

    NERVE CUFF FOR IMPLANTABLE ELECTRODE
    8.
    发明申请
    NERVE CUFF FOR IMPLANTABLE ELECTRODE 有权
    用于可植入电极的神经钳

    公开(公告)号:US20080046055A1

    公开(公告)日:2008-02-21

    申请号:US11839313

    申请日:2007-08-15

    IPC分类号: A61N1/05

    摘要: A flat interface nerve electrode provides a plurality of electrical contacts embedded in a non-conductive cuff structure, which acts to gently and non-evasively redefine the geometry of a nerve through the application of a force acting on the nerve without causing damage to the nerve. The cuff is open at one side and has a connection to a lead at the other side. During implantation the open sides of the cuff are closed so as to capture the nerve in the cuff in a single motion.

    摘要翻译: 平坦的界面神经电极提供嵌入非导电袖带结构中的多个电触点,其通过施加作用在神经上的力而轻轻地并且非显着地重新定义神经的几何形状,而不会对神经造成损伤 。 袖口在一侧开口,并且与另一侧的导线连接。 在植入期间,袖带的开放侧面被封闭,以便以单个运动捕获袖带中的神经。

    Scale Turning Device, Notably for Streamlined Tractor Rope Comprising Such Scales
    9.
    发明申请
    Scale Turning Device, Notably for Streamlined Tractor Rope Comprising Such Scales 有权
    缩小转向装置,特别适用于包括这种尺度的流线型拖拉机绳索

    公开(公告)号:US20100236465A1

    公开(公告)日:2010-09-23

    申请号:US12741823

    申请日:2008-11-06

    IPC分类号: B63B21/66

    CPC分类号: B63B21/663

    摘要: The present invention relates to a means for mutually aligning the scales of a rope streamlined by means of scales articulated to rotate about its axis, the alignment being necessary to enable such a rope to be wound onto the drum of a winch. It mainly consists of a device presenting a bevelled front face and comprising a cavity extending from front to rear, inside which passes the rope before it is wound. The cavity presents a longitudinal opening with two lateral edges, each edge following, from front to back, a profile in helical form, the two helices being coaxial to each other and with the axis of symmetry of the cavity. The wall of the cavity is also configured so as to follow the cross-sectional profile of the scale all along its path in the device. The device is arranged relative to the drum on which the rope is wound so that, given the length of the edges of the opening, regardless of the orientation of a scale on entering the device, the latter, on exiting, assumes the desired orientation, in the alignment of the adjacent scales. The invention applies notably to the systems for handling tractor ropes streamlined by means of scales, used on a ship to pull a submersible body cast off at sea.

    摘要翻译: 本发明涉及一种用于相互对准通过铰链流动的绳索的绳索相对于其轴线旋转的装置,所述对准是使得这种绳索能够卷绕在绞盘的滚筒上所必需的。 它主要由具有斜面前表面的装置组成,包括从前到后延伸的腔体,其内部在绳索缠绕之前穿过绳索。 空腔具有两个横向边缘的纵向开口,每个边缘从前到后依次为螺旋形轮廓,两个螺旋彼此同轴并且与空腔的对称轴线相同。 空腔的壁也被构造成沿着其在设备中的路径跟随标尺的横截面轮廓。 设备相对于缠绕绳索的滚筒布置,使得在给定开口的边缘的长度的情况下,无论标尺进入装置的方向如何,后者在退出时呈现期望的取向, 在相邻尺度的对齐中。 本发明特别适用于用于处理通过水垢流线化的拖拉机绳索的系统,用于在船上拉动在海上抛出的潜水体。