-
公开(公告)号：US20080176794A1
公开(公告)日：2008-07-24
申请号：US11877300
申请日：2007-10-23
申请人： Dominique P. Bridon , Robert S. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
发明人： Dominique P. Bridon , Robert S. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
-
公开(公告)号：US20080199483A1
公开(公告)日：2008-08-21
申请号：US11877221
申请日：2007-10-23
申请人： Dominique P. Bridon , Robert S. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
发明人： Dominique P. Bridon , Robert S. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
-
3.发明授权Long-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides 失效包含白蛋白和人类免疫缺陷病毒（HIV）肽的长效抗病毒融合抑制剂肽缀合物公开(公告)号：US07582301B1
公开(公告)日：2009-09-01
申请号：US09623533
申请日：2000-05-17
申请人： Dominique P. Bridon , Robert P. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
发明人： Dominique P. Bridon , Robert P. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
IPC分类号： A61K39/385 , A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
-
公开(公告)号：US07090851B1
公开(公告)日：2006-08-15
申请号：US09657336
申请日：2000-09-07
申请人： Dominique P. Bridon , Robert R. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
发明人： Dominique P. Bridon , Robert R. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
IPC分类号： A61K39/385
CPC分类号： C07K14/005 , C12N2740/16122
摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
-
5.发明授权Modified human immunodeficiency virus anti-fusogenic GP41 peptides comprising a maleimide-containing group 失效包含含马来酰亚胺基团的修饰的人免疫缺陷病毒抗融合GP41肽公开(公告)号：US07608271B2
公开(公告)日：2009-10-27
申请号：US10950010
申请日：2004-09-24
申请人： Dominique P. Bridon , Robert S. Dufresne , Nisssab Boudjellab , Martin Robitaille , Peter G. Milner
发明人： Dominique P. Bridon , Robert S. Dufresne , Nisssab Boudjellab , Martin Robitaille , Peter G. Milner
IPC分类号： A61K39/385 , A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
-
6.发明授权Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders 失效持久的胰高血糖素样肽2（glp-2）用于治疗胃肠道疾病和病症公开(公告)号：US07112567B2
公开(公告)日：2006-09-26
申请号：US10203808
申请日：2002-02-15
申请人： Dominique P. Bridon , Nissab Boudjellab , Roger Léger , Martin Robitaille , Karen Thibaudeau , Julie Carette
发明人： Dominique P. Bridon , Nissab Boudjellab , Roger Léger , Martin Robitaille , Karen Thibaudeau , Julie Carette
IPC分类号： A61K38/00
CPC分类号： C07K14/605 , A61K38/26 , A61K38/38 , A61K47/643 , C07K2319/00 , A61K2300/00
摘要： This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders or diseases such as inflammatory bowel disease and other gastrointestinal functions, from any segment of the gastrointestinal tract, from the oesophagus to the anus.
摘要翻译： 本发明涉及胰高血糖素样肽2（GLP-2）衍生物。 特别地，本发明涉及具有延长的体内半衰期的GLP-2肽衍生物，用于治疗或预防来自胃肠道的任何部分的胃肠道疾病或诸如炎性肠病和其它胃肠功能的疾病 食道到肛门。
-
7.发明申请LONG LASTING GLUCAGON-LIKE PEPTIDE 2 (GLP-2) FOR THE TREATMENT OF GASTROINTESTINAL DISEASES AND DISORDERS 审中-公开用于治疗胃肠疾病和疾病的长效GLUCAGON-like肽2（GLP-2）公开(公告)号：US20090312259A1
公开(公告)日：2009-12-17
申请号：US12505506
申请日：2009-07-19
申请人： Dominique P. Bridon , Nissab Boudjellab , Roger Leger , Martin Robitaille , Karen Thibaudeau , Julie Carette
发明人： Dominique P. Bridon , Nissab Boudjellab , Roger Leger , Martin Robitaille , Karen Thibaudeau , Julie Carette
IPC分类号： A61K38/16 , C07K14/00 , C07K14/765
CPC分类号： C07K14/605 , A61K38/26 , A61K38/38 , A61K47/643 , C07K2319/00 , A61K2300/00
摘要： This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular, this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders or diseases such as inflammatory bowel disease and other gastrointestinal functions, from any segment of the gastrointestinal tract, from the oesophagus to the anus.
摘要翻译： 本发明涉及胰高血糖素样肽2（GLP-2）衍生物。 特别地，本发明涉及具有延长的体内半衰期的GLP-2肽衍生物，用于治疗或预防胃肠道疾病或疾病如炎性肠病和其他胃肠功能，从胃肠道的任何部分，从 食道到肛门。
-
8.发明授权Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders 失效持久的胰高血糖素样肽2（GLP-2）用于治疗胃肠道疾病和病症公开(公告)号：US07737251B2
公开(公告)日：2010-06-15
申请号：US11318323
申请日：2005-12-23
申请人： Dominique P. Bridon , Nissab Boudjellab , Roger Leger , Martin Robitaille , Karen Thibaudeau , Julie Carette
发明人： Dominique P. Bridon , Nissab Boudjellab , Roger Leger , Martin Robitaille , Karen Thibaudeau , Julie Carette
CPC分类号： C07K14/605 , A61K38/26 , A61K38/38 , A61K47/643 , C07K2319/00 , A61K2300/00
摘要： This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular, this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders or diseases such as inflammatory bowel disease and other gastrointestinal functions, from any segment of the gastrointestinal tract, from the oesophagus to the anus.
摘要翻译： 本发明涉及胰高血糖素样肽2（GLP-2）衍生物。 特别地，本发明涉及具有延长的体内半衰期的GLP-2肽衍生物，用于治疗或预防胃肠道疾病或疾病如炎性肠病和其它胃肠功能，从胃肠道的任何部分，从 食道到肛门。
-
公开(公告)号：US07268113B2
公开(公告)日：2007-09-11
申请号：US10203809
申请日：2002-02-01
申请人： Dominique P. Bridon , Nissab Boudjellab , Roger Léger , Martin Robitaille , Lucie Jetté , Corinne Benquet
发明人： Dominique P. Bridon , Nissab Boudjellab , Roger Léger , Martin Robitaille , Lucie Jetté , Corinne Benquet
IPC分类号： A61K38/18 , C07K14/475
摘要： This invention relates to growth hormone releasing factor (GRF) derivatives. In particular, this invention relates to GRF peptide derivatives having an extended in vivo half-life, for promoting the endogenous production or release of growth hormone in humans and animals.
摘要翻译： 本发明涉及生长激素释放因子（GRF）衍生物。 特别地，本发明涉及具有延长的体内半衰期的GRF肽衍生物，用于促进人和动物中生长激素的内源性产生或释放。
-
公开(公告)号：US06706892B1
公开(公告)日：2004-03-16
申请号：US09656121
申请日：2000-09-06
IPC分类号： A61K314015
CPC分类号： A61K9/0075 , A61K47/50 , A61K47/643
摘要： Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary solution protein are disclosed. Therapeutic agents useful in the invention include wound healing agents, antibiotics, anti-inflammatories, anti-oxidants, anti-proliferatives, immunosupressants, anti-infective and anti-cancer agents.
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.033 秒)
