公开(公告)号：US07153286B2

公开(公告)日：2006-12-26

申请号：US10155603

申请日：2002-05-24

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Shahid Din ,  Brian Lauman ,  Rick Kienman ,  Ian Richardson ,  Joseph H. Bowman, Jr. ,  Loren M. Lundtveit ,  Jose Alvaro ,  Bruce Ming-Da Eu ,  Sherwin Shang

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Shahid Din ,  Brian Lauman ,  Rick Kienman ,  Ian Richardson ,  Joseph H. Bowman, Jr. ,  Loren M. Lundtveit ,  Jose Alvaro ,  Bruce Ming-Da Eu ,  Sherwin Shang

IPC分类号： A31M37/00 ,  C02F1/33 ,  A61M1/36

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： The present invention provides automated peritoneal dialysis systems, methods of operating the systems and devices for performing same. A typical therapy performed by the present invention begins by draining dialysis solution that is already in the patient's peritoneal cavity. The system pumps fresh dialysate from one of a plurality of supply bags, through an in-line heater to the patient's peritoneal cavity. After a dwell period, the spent dialysate in the cavity is pumped out of the patient to a drain or other disposal means. The system then pumps fresh dialysate from the supply bags to the patient and the procedure is repeated as defined in the therapy protocol. The system can pump a last bag of dialysate to the peritoneal cavity for an extended dwell, such as a daytime dwell.

公开(公告)号：US07789849B2

公开(公告)日：2010-09-07

申请号：US11614850

申请日：2006-12-21

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Shahid Din ,  Brian Lauman ,  Rick Kienman ,  Ian Richardson ,  Joseph H. Bowman, Jr. ,  Loren M. Lundtveil ,  Jose Alvaro ,  Bruce Ming-Da Eu ,  Sherwin Shang

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Shahid Din ,  Brian Lauman ,  Rick Kienman ,  Ian Richardson ,  Joseph H. Bowman, Jr. ,  Loren M. Lundtveil ,  Jose Alvaro ,  Bruce Ming-Da Eu ,  Sherwin Shang

IPC分类号： A61M1/00 ,  A61M37/00

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes: (i) an enclosure; (ii) a stepper motor housed by the enclosure; (iii) a pump head in operable communication with the stepper motor; and (iv) a disposable unit including at least one flexible membrane attached to a rigid piece, the enclosure configured to receive the disposable unit such that the stepper motor can move the pump head towards and away from the flexible membrane to cause, (a) the flexible membrane to move outwardly with respect to the rigid piece as the pump head is moved away from the disposable unit, and (b) the flexible membrane to move inwardly with respect to the rigid piece as the pump head is moved away from the disposable unit.

摘要翻译： 腹膜透析系统包括：（i）外壳; （ii）由外壳容纳的步进电机; （iii）与步进电机可操作地连通的泵头; （iv）包括附接到刚性件的至少一个柔性膜的一次性单元，所述外壳被配置为容纳所述一次性单元，使得所述步进马达可以朝向和远离所述柔性膜移动所述泵头，从而使（a） 柔性膜随着泵头离开一次性单元而相对于刚性件向外移动，以及（b）柔性膜相对于刚性件向内移动，因为泵头远离一次性物品 单元。

公开(公告)号：US20070213651A1

公开(公告)日：2007-09-13

申请号：US11614850

申请日：2006-12-21

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Shahid Din ,  Brian Lauman ,  Rick Kienman ,  Ian Richardson ,  Joseph Bowman ,  Loren Lundtveil ,  Jose Alvaro ,  Bruce Eu ,  Sherwin Shang

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Shahid Din ,  Brian Lauman ,  Rick Kienman ,  Ian Richardson ,  Joseph Bowman ,  Loren Lundtveil ,  Jose Alvaro ,  Bruce Eu ,  Sherwin Shang

IPC分类号： B01D61/28

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes: (i) an enclosure; (ii) a stepper motor housed by the enclosure; (iii) a pump head in operable communication with the stepper motor; and (iv) a disposable unit including at least one flexible membrane attached to a rigid piece, the enclosure configured to receive the disposable unit such that the stepper motor can move the pump head towards and away from the flexible membrane to cause, (a) the flexible membrane to move outwardly with respect to the rigid piece as the pump head is moved away from the disposable unit, and (b) the flexible membrane to move inwardly with respect to the rigid piece as the pump head is moved away from the disposable unit.

摘要翻译： 腹膜透析系统包括：（i）外壳; （ii）由外壳容纳的步进电机; （iii）与步进电机可操作地连通的泵头; （iv）包括附接到刚性件的至少一个柔性膜的一次性单元，所述外壳被配置为容纳所述一次性单元，使得所述步进马达可以朝向和远离所述柔性膜移动所述泵头，从而使（a） 柔性膜随着泵头离开一次性单元而相对于刚性件向外移动，以及（b）柔性膜相对于刚性件向内移动，因为泵头远离一次性物品 单元。

公开(公告)号：US20110040244A1

公开(公告)日：2011-02-17

申请号：US12903902

申请日：2010-10-13

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

IPC分类号： A61M1/28

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes a hardware unit including a piston having a contact surface and a stepper motor configured to move the piston; and a disposable unit received by the hardware unit, the disposable unit including a moveable membrane operable with the contact surface of the piston, the piston moveable towards and away from the disposable unit, wherein (i) the piston and the membrane are positioned relative to each other and (ii) the hardware unit is configured to apply a negative pressure to the moveable membrane of the disposable unit so that the negative pressure causes the moveable membrane to contact and conform to a shape of the contact surface and to follow the piston as the piston is moved away from the disposable unit by the stepper motor, and wherein the shape-contacted membrane moves with the piston as the piston is moved into the disposable unit by the stepper motor.

摘要翻译： 腹膜透析系统包括硬件单元，其包括具有接触表面的活塞和构造成移动活塞的步进马达; 以及由所述硬件单元接收的一次性单元，所述一次性单元包括可与所述活塞的接触表面一起操作的可移动膜，所述活塞朝向和远离所述一次性单元移动，其中（i）所述活塞和所述膜相对于 （ii）硬件单元构造成对一次性单元的可移动膜施加负压，使得负压使得可移动膜接触并符合接触表面的形状并且将活塞跟随作为 活塞通过步进电动机移动离开一次性单元，并且其中当活塞通过步进电机移动到一次性单元中时，形状接触的膜随活塞一起移动。

公开(公告)号：US07815595B2

公开(公告)日：2010-10-19

申请号：US11614858

申请日：2006-12-21

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

IPC分类号： A61M1/00

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes: (i) a hardware unit, the hardware unit including a pump actuator; (ii) a disposable unit received by the hardware unit, the disposable unit having a moveable membrane operable with the pump actuator, the pump actuator moveable towards and away from the disposable unit; and (iii) the hardware unit and disposable unit configured to hold a negative pressure between the pump actuator and the moveable membrane of the disposable unit, the negative pressure causing the moveable membrane to follow the pump actuator as the actuator is moved away from the disposable unit, the pump actuator and membrane positioned relative to each other such that the membrane moves with the pump actuator as the actuator is moved into the disposable unit.

摘要翻译： 腹膜透析系统包括：（i）硬件单元，硬件单元包括泵致动器; （ii）由所述硬件单元接收的一次性单元，所述一次性单元具有可与所述泵致动器一起操作的可移动膜，所述泵致动器可朝向和远离所述一次性单元移动; 和（iii）配置成在泵致动器和一次性单元的可移动膜之间保持负压的硬件单元和一次性单元，当致动器从一次性部件移动离开时，负压使得可移动膜跟随泵致动器 单元，泵致动器和膜相对于彼此定位，使得当致动器移动到一次性单元中时，膜随着泵致动器移动。

公开(公告)号：US08376999B2

公开(公告)日：2013-02-19

申请号：US13303191

申请日：2011-11-23

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

IPC分类号： A61M37/00

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes: a hardware unit including a piston having a contact surface, a pneumatic source for supplying a negative pressure, a stepper motor, a controller including a processor and memory programmed to control the pneumatic source and the stepper motor, and a video monitor operating with a touch screen for sending and receiving information to and from the controller; and a disposable unit including a moveable membrane positioned adjacent to the contact surface, the programmed processor and memory operable to (i) cause the pneumatic source to apply the negative pressure to the membrane so that the negative pressure moves the membrane to conform to a shape of the contact surface and (ii) control the stepper motor so that the membrane follows the piston as the piston is moved away from the disposable unit and moves with the piston as the piston is moved into the disposable unit.

摘要翻译： 腹膜透析系统包括：包括具有接触表面的活塞，用于提供负压的气动源的硬件单元，步进电动机，包括处理器的控制器和被编程为控制气动源和步进电动机的存储器，以及 使用触摸屏操作的视频监视器，用于向控制器发送和接收信息; 以及包括邻近接触表面定位的可移动膜的一次性单元，所述编程处理器和存储器可操作以（i）使所述气源将所述负压施加到所述膜，使得所述负压使所述膜移动以符合形状 和（ii）控制步进电机，使得当活塞从一次性单元移开时膜与活塞相接触，并随着活塞移动到一次性单元中而与活塞一起移动。

公开(公告)号：US20120071816A1

公开(公告)日：2012-03-22

申请号：US13303191

申请日：2011-11-23

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

IPC分类号： A61M1/28

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes: a hardware unit including a piston having a contact surface, a pneumatic source for supplying a negative pressure, a stepper motor, a controller including a processor and memory programmed to control the pneumatic source and the stepper motor, and a video monitor operating with a touch screen for sending and receiving information to and from the controller; and a disposable unit including a moveable membrane positioned adjacent to the contact surface, the programmed processor and memory operable to (i) cause the pneumatic source to apply the negative pressure to the membrane so that the negative pressure moves the membrane to conform to a shape of the contact surface and (ii) control the stepper motor so that the membrane follows the piston as the piston is moved away from the disposable unit and moves with the piston as the piston is moved into the disposable unit.

摘要翻译： 腹膜透析系统包括：包括具有接触表面的活塞，用于提供负压的气动源的硬件单元，步进电动机，包括处理器的控制器和被编程为控制气动源和步进电动机的存储器，以及 使用触摸屏操作的视频监视器，用于向控制器发送和接收信息; 以及包括邻近接触表面定位的可移动膜的一次性单元，所述编程处理器和存储器可操作以（i）使所述气源将所述负压施加到所述膜，使得所述负压使所述膜移动以符合形状 和（ii）控制步进电机，使得当活塞从一次性单元移开时膜与活塞相接触，并随着活塞移动到一次性单元中而与活塞一起移动。

公开(公告)号：US08066671B2

公开(公告)日：2011-11-29

申请号：US12903902

申请日：2010-10-13

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

IPC分类号： A61M37/00

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes a hardware unit including a piston having a contact surface and a stepper motor configured to move the piston; and a disposable unit received by the hardware unit, the disposable unit including a moveable membrane operable with the contact surface of the piston, the piston moveable towards and away from the disposable unit, wherein (i) the piston and the membrane are positioned relative to each other and (ii) the hardware unit is configured to apply a negative pressure to the moveable membrane of the disposable unit so that the negative pressure causes the moveable membrane to contact and conform to a shape of the contact surface and to follow the piston as the piston is moved away from the disposable unit by the stepper motor, and wherein the shape-contacted membrane moves with the piston as the piston is moved into the disposable unit by the stepper motor.

摘要翻译： 腹膜透析系统包括硬件单元，其包括具有接触表面的活塞和构造成移动活塞的步进马达; 以及由所述硬件单元接收的一次性单元，所述一次性单元包括可与所述活塞的接触表面一起操作的可移动膜，所述活塞朝向和远离所述一次性单元移动，其中（i）所述活塞和所述膜相对于 （ii）硬件单元构造成对一次性单元的可移动膜施加负压，使得负压使得可移动膜接触并符合接触表面的形状并且将活塞跟随作为 活塞通过步进电动机移动离开一次性单元，并且其中当活塞通过步进电机移动到一次性单元中时，形状接触的膜随活塞一起移动。

公开(公告)号：US20070149913A1

公开(公告)日：2007-06-28

申请号：US11614858

申请日：2006-12-21

申请人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

发明人： Don Busby ,  Peter Hopping ,  Robert Childers ,  Rick Kienman ,  Ian Richardson

IPC分类号： A61M37/00

CPC分类号： A61M1/267 ,  A61M1/166 ,  A61M1/28 ,  A61M1/281 ,  A61M1/288 ,  A61M2205/127 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/583 ,  G06F19/00

摘要： A peritoneal dialysis system includes: (i) a hardware unit, the hardware unit including a pump actuator; (ii) a disposable unit received by the hardware unit, the disposable unit having a moveable membrane operable with the pump actuator, the pump actuator moveable towards and away from the disposable unit; and (iii) the hardware unit and disposable unit configured to hold a negative pressure between the pump actuator and the moveable membrane of the disposable unit, the negative pressure causing the moveable membrane to follow the pump actuator as the actuator is moved away from the disposable unit, the pump actuator and membrane positioned relative to each other such that the membrane moves with the pump actuator as the actuator is moved into the disposable unit.

摘要翻译： 腹膜透析系统包括：（i）硬件单元，硬件单元包括泵致动器; （ii）由所述硬件单元接收的一次性单元，所述一次性单元具有可与所述泵致动器一起操作的可移动膜，所述泵致动器可朝向和远离所述一次性单元移动; 和（iii）配置成在泵致动器和一次性单元的可移动膜之间保持负压的硬件单元和一次性单元，当致动器从一次性部件移动离开时，负压使得可移动膜跟随泵致动器 单元，泵致动器和膜相对于彼此定位，使得当致动器移动到一次性单元中时，膜随着泵致动器移动。

公开(公告)号：US20050131332A1

公开(公告)日：2005-06-16

申请号：US10982170

申请日：2004-11-04

申请人： Thomas Kelly ,  Robert Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Mutasem Sayyid ,  Shahid Din

发明人： Thomas Kelly ,  Robert Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Mutasem Sayyid ,  Shahid Din

IPC分类号： A61M1/16 ,  A61M1/34 ,  B01D61/58 ,  A61M37/00

CPC分类号： A61M1/3621 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1062 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/1621 ,  A61M1/1629 ,  A61M1/1633 ,  A61M1/1635 ,  A61M1/1656 ,  A61M1/166 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/288 ,  A61M1/341 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3444 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3656 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/75

摘要： A system, method and apparatus for performing a renal replacement therapy is provided. In one embodiment, two small high flux dialyzers are connected in series. A restriction is placed between the two dialyzers in the dialysate flow path. The restriction is variable and adjustable in one preferred embodiment. The restriction builds a positive pressure in the venous dialyzer, causing a high degree of intentional backfiltration. That backfiltration causes a significant flow of dialysate through the high flux venous membrane directly into the patient's blood. That backfiltered solution is subsequently ultrafiltered from the patient from the arterial dialyzer. The diffusion of dialysate into the venous filter and removal of dialysate from the arterial dialyzer causes a convective transport of toxins from the patient. Additionally, the dialysate that does not diffuse directly into the patient but instead flows across the membranes of both dialyzers provides a diffusive clearance of waste products.

摘要翻译： 提供了一种用于进行肾脏替代疗法的系统，方法和装置。 在一个实施例中，两个小型高通量透析器串联连接。 在透析液流动路径中的两个透析器之间进行限制。 在一个优选实施例中，限制是可变的和可调节的。 限制在静脉透析器中产生正压，导致高度有意的反渗透。 该回流导致透析液通过高通量静脉膜直接流入患者血液中。 随后从动脉透析器将患者的过滤后的溶液进行超滤。 透析液扩散到静脉过滤器中，从动脉透析器中除去透析液会导致患者的毒素对流运输。 另外，透析液不直接扩散到患者体内，而是穿过两个透析器的膜，从而提供废物的扩散清除。