Polynucleotides encoding GDNFRα
    4.
    发明授权
    Polynucleotides encoding GDNFRα 有权
    编码GDNFRα的多核苷酸

    公开(公告)号:US07691606B2

    公开(公告)日:2010-04-06

    申请号:US11336555

    申请日:2006-01-20

    IPC分类号: C12N15/12 C12N15/79 C12N15/85

    摘要: GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.

    摘要翻译: GDNFRα,GDNFRα细胞外结构域(ECD),GDNFRα变体,嵌合GDNFRα(例如GDNFRα免疫粘附素)和与其结合的抗体(包括激动剂和中和抗体)。 描述了这些分子的各种用途,包括通过向细胞提供GDNFRα来调节对GDNFRα-配体(例如GDNF)的响应来调节细胞活性和存活的方法。 还提供了使用GDNFRα,GDNF或其分别或复合物的激动剂来治疗肾脏疾病的方法。

    GDNF receptorα
    5.
    发明授权
    GDNF receptorα 有权
    GDNF接受者

    公开(公告)号:US07105484B2

    公开(公告)日:2006-09-12

    申请号:US10033350

    申请日:2001-11-02

    IPC分类号: A61K38/17 C07K14/71

    摘要: GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.

    摘要翻译: 公开了GDNFRalpha,GDNFRalpha细胞外结构域(ECD),GDNFRalpha变体,嵌合GDNFRα(例如,GDNFRα免疫粘附素)和与其结合的抗体(包括激动剂和中和抗体)。 描述了这些分子的各种用途,包括通过向细胞提供GDNFRα来调节对GDNFRα-配体(例如GDNF)的响应来调节细胞活性和存活的方法。 还提供了分别或复合的使用GDNFRalpha,GDNF或其激动剂来治疗肾脏疾病的方法。

    Paper supply adjustment mechanism
    8.
    发明授权
    Paper supply adjustment mechanism 有权
    纸张供应调整机制

    公开(公告)号:US6158342A

    公开(公告)日:2000-12-12

    申请号:US406156

    申请日:1999-09-27

    申请人: Mark W. Moore

    发明人: Mark W. Moore

    摘要: A mechanism for a label printer that automatically locks two, spaced-apart, paper supporting guides. A supply roll of paper is disposed between the guides, and the guides are adjusted to a proper paper width position. The guides are each mounted on a rack that engages a centralized pinion gear disposed in the cover plate that is closed over the printer housing. The guides are locked in an adjusted position when the cover is latched to the housing of the label printer.

    摘要翻译: 用于标签打印机的机构,其自动锁定两个间隔开的纸张支撑引导件。 在导向件之间设置供应卷纸,并且将引导件调整到适当的纸张宽度位置。 引导件各自安装在齿条上,该齿条与设置在盖板上的集中式小齿轮接合,该小齿轮封闭在打印机壳体上。 当盖子被锁定到标签打印机的外壳上时,导轨被锁定在调整位置。