High molecular weight chelation structure
    10.
    发明申请
    High molecular weight chelation structure 失效
    高分子量螯合结构

    公开(公告)号:US20070274945A1

    公开(公告)日:2007-11-29

    申请号:US11441359

    申请日:2006-05-25

    摘要: A chelation structure and method of forming and using the chelation structure. The chelation structure has a backbone that includes a linear sequence of monomeric backbone units, at least one polymer side chain, and at least one chelator side chain. The side chains are each covalently coupled to the backbone at one of the monomeric backbone units by a bond that is independently biodegradable or non-biodegradable. The chelation structure is synthesized by Radical Addition Fragmentation Transfer (RAFT), Atom Transfer Radical Polymerization (ATRP), or Free Radical Polymerization (FRP). The chelation structure, individually or in combination with a shuttle chelator, may be introduced into a mammal to bind an amount of a substance in a mammal, the substance being at least one of a metal and heme. The chelation structure has a log stability constant exceeding that of the shuttle chelator for binding the substance within cells of the mammal.

    摘要翻译: 一种螯合结构和形成和使用螯合结构的方法。 螯合结构具有主链,其包括单体主链单元,至少一个聚合物侧链和至少一个螯合剂侧链的线性序列。 侧链通过单独的可生物降解或不可生物降解的键共价偶联到单体主链单元之一的骨架上。 螯合结构通过自由基加成转移(RAFT),原子转移自由基聚合(ATRP)或自由基聚合(FRP)合成。 螯合结构单独地或与穿梭螯合剂组合可以引入到哺乳动物中以结合一定量的哺乳动物物质,该物质是金属和血红素中的至少一种。 螯合结构的对数稳定性常数超过用于结合哺乳动物细胞内的物质的穿梭螯合剂的对数稳定性。