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公开(公告)号:US09346029B2
公开(公告)日:2016-05-24
申请号:US11916525
申请日:2006-06-06
IPC分类号: A61P41/00 , A61K31/765 , A01N1/02 , C08G65/00 , B01F17/00 , A61K9/00 , A61K47/34 , C08L71/00
CPC分类号: A61K9/0026 , A61K47/34 , A61K47/60 , B01F17/0021 , C08G65/34 , C08G2650/04 , C08G2650/32 , C08G2650/38 , C08L71/00
摘要: This invention provides the use of a polymer comprising a hyperbranched polyether polyol such as hyperbranched polyglycerol as a serum albumin substitute. Also provided are high molecular weight hyperbranched polyglycerol polymers suitable for a variety of medical and non-medical uses including methods for making such high molecular weight polymers.
摘要翻译: 本发明提供了包含超支化聚醚多元醇如超支化聚甘油作为血清白蛋白替代物的聚合物的用途。 还提供了适用于各种医疗和非医学用途的高分子量超支化聚甘油聚合物,包括制备这种高分子量聚合物的方法。
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公开(公告)号:US20080292579A1
公开(公告)日:2008-11-27
申请号:US11916525
申请日:2006-06-06
IPC分类号: C08G65/00 , A01N1/02 , A61K31/765 , A61P41/00
CPC分类号: A61K9/0026 , A61K47/34 , A61K47/60 , B01F17/0021 , C08G65/34 , C08G2650/04 , C08G2650/32 , C08G2650/38 , C08L71/00
摘要: This invention provides the use of a polymer comprising a hyperbranched polyether polyol such as hyperbranched polyglycerol as a serum albumin substitute. Also provided are high molecular weight hyperbranched polyglycerol polymers suitable for a variety of medical and non-medical uses including methods for making such high molecular weight polymers.
摘要翻译: 本发明提供了包含超支化聚醚多元醇如超支化聚甘油作为血清白蛋白替代物的聚合物的用途。 还提供了适用于各种医疗和非医学用途的高分子量超支化聚甘油聚合物,包括制备这种高分子量聚合物的方法。
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公开(公告)号:US20130022647A1
公开(公告)日:2013-01-24
申请号:US13504841
申请日:2011-09-27
IPC分类号: C07C237/22 , B01D21/00 , A61K9/00 , C07D407/14 , C08B37/10 , A61K31/727
CPC分类号: A61K31/795 , A61K9/0014 , A61K9/06 , A61K31/765 , A61K31/785 , A61K47/34 , A61M1/3675 , A61M1/3679 , A61M2202/0021 , A61M2202/0413 , A61M2202/0478 , B01D15/36 , C08G73/024 , C08G2340/00 , C08L71/02
摘要: Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.
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公开(公告)号:US09962521B2
公开(公告)日:2018-05-08
申请号:US13997036
申请日:2012-02-03
IPC分类号: A61M31/00 , A61M25/00 , A61M25/01 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61B17/06 , A61B17/064 , A61B17/122 , A61B17/00 , A61B90/00
CPC分类号: A61M25/0045 , A61B17/06166 , A61B17/064 , A61B17/122 , A61B2017/00526 , A61B2017/00623 , A61B2017/00858 , A61B2017/00867 , A61B2017/00982 , A61B2017/00995 , A61B2090/065 , A61L29/041 , A61L29/085 , A61L29/16 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2400/16 , A61M25/0009 , A61M25/0158 , Y10T428/23979 , C08L33/10 , C08L27/06
摘要: Devices including a flexible substrate and a grafted polymer brush coating on at least one surface of the flexible substrate and methods for making and using such devices are provided herein. The grafted polymer brush included on the devices allow for controlled bending of the device during use.
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公开(公告)号:US20130303981A1
公开(公告)日:2013-11-14
申请号:US13997036
申请日:2012-02-03
IPC分类号: A61M25/00
CPC分类号: A61M25/0045 , A61B17/06166 , A61B17/064 , A61B17/122 , A61B2017/00526 , A61B2017/00623 , A61B2017/00858 , A61B2017/00867 , A61B2017/00982 , A61B2017/00995 , A61B2090/065 , A61L29/041 , A61L29/085 , A61L29/16 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2400/16 , A61M25/0009 , A61M25/0158 , Y10T428/23979 , C08L33/10 , C08L27/06
摘要: Devices including a flexible substrate and a grafted polymer brush coating on at least one surface of the flexible substrate and methods for making and using such devices are provided herein. The grafted polymer brush included on the devices allow for controlled bending of the device during use.
摘要翻译: 本文提供了包括柔性基底和在柔性基底的至少一个表面上的接枝聚合物刷涂层的装置以及用于制造和使用这种装置的方法。 包含在设备中的接枝聚合物刷子允许在使用期间该装置的受控弯曲。
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公开(公告)号:US08637008B2
公开(公告)日:2014-01-28
申请号:US13458899
申请日:2012-04-27
CPC分类号: A61K31/795 , A61K9/0014 , A61K9/06 , A61K31/765 , A61K31/785 , A61K47/34 , A61M1/3675 , A61M1/3679 , A61M2202/0021 , A61M2202/0413 , A61M2202/0478 , B01D15/36 , C08G73/024 , C08G2340/00 , C08L71/02
摘要: Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.
摘要翻译: 本文提供的实施方案涉及各种聚合物。 一些聚合物实施方案是肝素结合聚合物。 肝素结合聚合物的一些实施方案可用于与肝素结合,用于分离,纯化,除去和/或分离肝素和肝素样分子等方法。
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公开(公告)号:US08519189B2
公开(公告)日:2013-08-27
申请号:US13504841
申请日:2011-09-27
IPC分类号: C07C237/22 , C08B37/10 , A61K31/727 , A61K9/00 , C07D407/14
CPC分类号: A61K31/795 , A61K9/0014 , A61K9/06 , A61K31/765 , A61K31/785 , A61K47/34 , A61M1/3675 , A61M1/3679 , A61M2202/0021 , A61M2202/0413 , A61M2202/0478 , B01D15/36 , C08G73/024 , C08G2340/00 , C08L71/02
摘要: Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.
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公开(公告)号:US20120308546A1
公开(公告)日:2012-12-06
申请号:US13458899
申请日:2012-04-27
CPC分类号: A61K31/795 , A61K9/0014 , A61K9/06 , A61K31/765 , A61K31/785 , A61K47/34 , A61M1/3675 , A61M1/3679 , A61M2202/0021 , A61M2202/0413 , A61M2202/0478 , B01D15/36 , C08G73/024 , C08G2340/00 , C08L71/02
摘要: Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.
摘要翻译: 本文提供的实施方案涉及各种聚合物。 一些聚合物实施方案是肝素结合聚合物。 肝素结合聚合物的一些实施方案可用于与肝素结合,用于分离,纯化,除去和/或分离肝素和肝素样分子等方法。
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公开(公告)号:US20170095421A1
公开(公告)日:2017-04-06
申请号:US15143738
申请日:2016-05-02
申请人: MARIA I.C. GYONGYOSSY-ISSA , Jayachandran N. Kizhakkedathu , Iren Constantinescu , William Campbell , Carlos A. Del Carpio Munoz
发明人: MARIA I.C. GYONGYOSSY-ISSA , Jayachandran N. Kizhakkedathu , Iren Constantinescu , William Campbell , Carlos A. Del Carpio Munoz
CPC分类号: A61K9/1271 , A61K9/1277 , A61K35/19 , A61K47/6911
摘要: A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.
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公开(公告)号:US20070274945A1
公开(公告)日:2007-11-29
申请号:US11441359
申请日:2006-05-25
IPC分类号: A61K31/785 , C08G63/91 , C08G63/48
CPC分类号: A61K31/785 , A61K47/58 , A61K47/60 , Y02A50/411
摘要: A chelation structure and method of forming and using the chelation structure. The chelation structure has a backbone that includes a linear sequence of monomeric backbone units, at least one polymer side chain, and at least one chelator side chain. The side chains are each covalently coupled to the backbone at one of the monomeric backbone units by a bond that is independently biodegradable or non-biodegradable. The chelation structure is synthesized by Radical Addition Fragmentation Transfer (RAFT), Atom Transfer Radical Polymerization (ATRP), or Free Radical Polymerization (FRP). The chelation structure, individually or in combination with a shuttle chelator, may be introduced into a mammal to bind an amount of a substance in a mammal, the substance being at least one of a metal and heme. The chelation structure has a log stability constant exceeding that of the shuttle chelator for binding the substance within cells of the mammal.
摘要翻译: 一种螯合结构和形成和使用螯合结构的方法。 螯合结构具有主链,其包括单体主链单元,至少一个聚合物侧链和至少一个螯合剂侧链的线性序列。 侧链通过单独的可生物降解或不可生物降解的键共价偶联到单体主链单元之一的骨架上。 螯合结构通过自由基加成转移(RAFT),原子转移自由基聚合(ATRP)或自由基聚合(FRP)合成。 螯合结构单独地或与穿梭螯合剂组合可以引入到哺乳动物中以结合一定量的哺乳动物物质,该物质是金属和血红素中的至少一种。 螯合结构的对数稳定性常数超过用于结合哺乳动物细胞内的物质的穿梭螯合剂的对数稳定性。
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