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公开(公告)号：US06672129B1
公开(公告)日：2004-01-06
申请号：US10067224
申请日：2002-02-07
申请人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
发明人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
IPC分类号： G01N3700
CPC分类号： A61M15/02 , A61M11/041 , A61M15/008 , A61M15/025 , A61M16/0066 , A61M2205/332 , A61M2205/3375 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/8206 , B01F3/022 , B01F3/04049 , B01F15/0255 , F24F2003/1689
摘要： A method and apparatus is disclosed which employs a pulse-controlled microdroplet fluid delivery system for precisely dispensing fragrances and other odor producing vapors. The pulse-controlled fluid delivery device is capable of ejecting microdroplets of fluid with a diameter less than 350 micrometers at a controlled ejection rate based upon inkjet printing technology. The pulse-controlled fluid delivery system includes mechanisms for vaporizing the fluids and delivery of the vapors to the nose, which is controlled by a programmable system controller capable of real time data-driven dispensing with a multi-fluid capability. Synthesis of custom fragrances is made possible by a multijet programmed control system which adjusts dispensing rates of components. Calibration of a prior art “electronic nose” is disclosed. A precise calibration gas is produced in real-time to counteract the effect of drifting.
摘要翻译： 公开了一种采用脉冲控制微滴流体输送系统来精确地分配香料和其它产生气味的蒸气的方法和装置。 脉冲控制流体输送装置能够以基于喷墨打印技术的受控喷射速率喷射直径小于350微米的流体微滴。 脉冲控制流体输送系统包括用于蒸发流体和将蒸气输送到鼻子的机构，其由可实时数据驱动分配多流体能力的可编程系统控制器控制。 通过调整组件的分配速率的多喷射编程控制系统可以实现定制香料的合成。 公开了现有技术的“电子鼻”的校准。 实时精确校准气体，以抵消漂移的影响。
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2.发明授权Method for fabricating laminated carrier for collecting interstitial fluid from the skin 失效用于从皮肤收集组织液的层压载体的制造方法公开(公告)号：US06620283B1
公开(公告)日：2003-09-16
申请号：US09993489
申请日：2001-11-27
IPC分类号： B32B3128
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2017/22089
摘要： A method for making a laminated carrier film for use in releasing interstitial fluid from skin for collection or measurement includes providing a printhead having an orifice and a reservoir containing a meltable absorber substance, the printhead being capable in response to electrical signals, to eject droplets of said meltable absorber substance from the orifice; supporting a carrier film having a series of spaced apart openings for a meltable absorber substance on a support base, in close proximity to the printhead, whereby the spaced apart openings on the carrier film can be positioned relative to the orifice to receive absorber substance droplets ejected from the printhead; filling the spaced apart openings of the carrier film with meltable absorber substance ejected from the printhead; and covering the carrier film on one side with a clear polymer film strip selected to allow laser energy to pass through the clear polymer film in order to reach the meltable absorber substance inside the openings.
摘要翻译： 制备用于从皮肤释放组织液以进行收集或测量的层压载体膜的方法包括提供具有孔的打印头和包含可熔化吸收物质的储存器，该打印头能够响应于电信号而喷射液滴 所述可熔化的吸收剂物质来自孔口; 支撑载体膜，其具有一系列间隔开的开口，用于紧靠打印头的支撑基座上的可熔化吸收体，由此载体膜上的间隔开的开口可以相对于孔口定位，以接收喷射的吸收物质液滴 从打印头; 用从所述打印头喷射的可熔化的吸收体填充所述载体膜的间隔开的开口; 并且在一侧覆盖载体膜，其中所述透明聚合物膜条被选择为允许激光能量通过透明聚合物膜以便到达开口内部的可熔化吸收体。
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公开(公告)号：US06390453B1
公开(公告)日：2002-05-21
申请号：US09845714
申请日：2001-04-30
申请人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
发明人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
IPC分类号： B01F304
CPC分类号： B01F3/04049 , A61M11/001 , A61M11/042 , A61M15/02 , A61M15/025 , A61M2205/8206 , B01F3/022 , B01F15/0255 , F24F2003/1689 , Y10S261/65 , Y10S261/88
摘要： A method and apparatus is disclosed which employs a pulse-controlled microdroplet fluid delivery system for precisely dispensing fragrances and other odor producing vapors. The pulse-controlled fluid delivery device is capable of ejecting microdroplets of fluid with a diameter less than 350 micrometers at a controlled ejection rate based upon ink-jet printing technology. The pulse-controlled fluid delivery system includes mechanisms for vaporizing the fluids and delivery of the vapors to the nose, which is controlled by a programmable system controller capable of real time data-driven dispensing with a multi-fluid capability. Synthesis of custom fragrances is made possible by a multijet programmed control system which adjusts dispensing rates of components. Calibration of a prior art “electronic nose” is disclosed. A precise calibration gas is produced in real-time to counteract the effect of drifting.
摘要翻译： 公开了一种采用脉冲控制微滴流体输送系统来精确地分配香料和其它产生气味的蒸气的方法和装置。 脉冲控制流体输送装置能够以基于喷墨打印技术的受控喷射速率喷射直径小于350微米的流体微滴。 脉冲控制流体输送系统包括用于蒸发流体和将蒸气输送到鼻子的机构，其由可实时数据驱动分配多流体能力的可编程系统控制器控制。 通过调整组件的分配速率的多喷射编程控制系统可以实现定制香料的合成。 公开了现有技术的“电子鼻”的校准。 实时精确校准气体，以抵消漂移的影响。
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公开(公告)号：US06338715B1
公开(公告)日：2002-01-15
申请号：US09540836
申请日：2000-03-31
IPC分类号： A61B508
CPC分类号： A61B5/4011
摘要： A more reliable and precise method of determining the olfactory threshold is provided by a digitally operated apparatus that dispenses controlled amounts of a volatile test fluid from a digital jetting device of the type used for ink jet printing. A precise number and size of micro droplets are dispensed onto a heater which vaporizes the fluid at a test location where a patient can sniff and report whether the odor is sensed. Incremental adjustments are made to determine the approximate threshold of olfactory perception of the odor. Sensors are included to verify dispensing and to coordinate dispensing with breathing.
摘要翻译： 用于确定嗅觉阈值的更可靠和精确的方法由数字操作的装置提供，该装置从用于喷墨打印的类型的数字喷射装置中分配受控量的挥发性测试流体。 将精确数量和大小的微滴分配到加热器上，该加热器在患者可以窥视并报告是否检测到气味的测试位置使流体蒸发。 进行增量调整，以确定气味嗅觉的近似阈值。 包括传感器以验证分配并协调点胶呼吸。
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公开(公告)号：US06334851B1
公开(公告)日：2002-01-01
申请号：US09567915
申请日：2000-05-10
IPC分类号： A61B500
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2017/22089
摘要： A carrier film has one or more openings or wells loaded with a meltable absorbing substance for absorbing laser energy. The carrier film has a clear film which covers one side of the opening containing the absorber substance and the open side of the opening in the carrier film is positioned adjacent to the skin and irradiated through the clear cover film by a laser beam. The melted laser energy absorbing substance is ejected to form a spot laying on the skin. After moving the carrier film, a laser beam impinges the spot thereby raising a tiny blister on the skin containing interstitial fluid. The interstitial fluid is collected for diagnosis and analysis. A method of making and loading the carrier film with a digitally operated dispenser of the type used for ink jet printing is disclosed. Special construction of the opening appears to enhance ejection.
摘要翻译： 载体膜具有一个或多个装有可吸收吸收物质的开口或孔，用于吸收激光能量。 载体膜具有透明膜，其覆盖包含吸收体的开口的一侧，并且载体膜中的开口的开放侧定位成与皮肤相邻并且通过激光束透过透明覆盖膜照射。 熔化的激光能量吸收物质被喷射以形成铺在皮肤上的斑点。 在移动载体膜之后，激光束撞击斑点，从而在含有间质液的皮肤上引起微小的气泡。 收集间质液进行诊断和分析。 公开了一种使用用于喷墨印刷的数字操作的分配器来制造和加载载体膜的方法。 开幕式的特殊构造似乎增强了弹射。
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公开(公告)号：US5658802A
公开(公告)日：1997-08-19
申请号：US524781
申请日：1995-09-07
IPC分类号： B01J19/00 , B01L3/02 , B01L99/00 , B41J3/407 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/543 , G01N35/10
CPC分类号： G01N33/54366 , B01J19/0046 , B01L3/0268 , B01L3/0293 , B41J3/407 , B82Y30/00 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00621 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00686 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N2035/1041
摘要： Arrays of electro-mechanical dispensers are used to form extremely small drops of fluid and locate them precisely on substrate surfaces in miniature arrays. The printed arrays may consist of DNA, immunoassay reagents or the like. A positioning support such as an X-Y table moves the dispensing devices and substrate surfaces relative to each other to locate the drops on the substrates in predetermined patterns. Arrays of probes as dense as one thousand per square centimeter with center-to-center spacing as small as twenty-five micrometers are formed.
摘要翻译： 电子机械分配器的阵列用于形成非常小的液滴，并将它们精确地定位在微型阵列的基板表面上。 印刷的阵列可以由DNA，免疫测定试剂等组成。 诸如X-Y台之类的定位支撑件相对于彼此移动分配装置和基板表面，以预定图案将液滴定位在基板上。 形成密度为千平方厘米的中心至中心间距小至二十五微米的探针阵列。
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公开(公告)号：US5554247A
公开(公告)日：1996-09-10
申请号：US420152
申请日：1995-04-11
申请人： John R. Pies , David B. Wallace , Donald J. Hayes
发明人： John R. Pies , David B. Wallace , Donald J. Hayes
CPC分类号： B41J2/1623 , B41J2/14209 , B41J2/1609 , B41J2/1618 , B41J2/1632 , B41J2002/14379 , Y10T156/1064 , Y10T156/1082 , Y10T29/42 , Y10T29/49401
摘要： Method for manufacturing a sidewall actuatable, high density channel array for an ink jet printhead. A first surface of a main body portion formed from an inactive material is conductively bonded to a first surface of a first intermediate body portion formed from an active material. A plurality of parallel grooves are then machined through the first intermediate body portion and part of the main body portion to form a plurality of channels separated by a corresponding plurality of sidewall actuators comprised of a first sidewall section formed from an inactive material and a second sidewall section formed from an active material. A top body portion is then conductively mounted to the intermediate body portion.
摘要翻译： 制造用于喷墨打印头的可侧壁致动的高密度通道阵列的方法。 由非活性材料形成的主体部分的第一表面导电结合到由活性材料形成的第一中间体部分的第一表面上。 然后通过第一中间体部分和主体部分的一部分加工多个平行的凹槽，以形成由相应的多个侧壁致动器隔开的多个通道，该侧壁致动器包括由非活性材料形成的第一侧壁部分和第二侧壁 由活性物质形成。 然后将顶部主体部分导电地安装到中间体部分。
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公开(公告)号：US5400064A
公开(公告)日：1995-03-21
申请号：US859671
申请日：1992-03-30
申请人： John R. Pies , David B. Wallace , Donald J. Hayes
发明人： John R. Pies , David B. Wallace , Donald J. Hayes
CPC分类号： B41J2/1623 , B41J2/14209 , B41J2/155 , B41J2/1609 , B41J2/1618 , B41J2/1632
摘要： An ink jet printhead includes of a lower body part having a base section and a plurality of generally parallel spaced projections extending upwardly therefrom and an upper body part having a top section and a corresponding plurality of generally parallel spaced projections extending downwardly therefrom. The top sides of the lower body projections are conductively mounted to the bottom sides of the upper body projections to form sidewalls which define a plurality of ink-carrying channels. Strips of a conductive adhesive mount the lower and upper body projections together and a controller is electrically connected to the strips to selectively impart either a positive, zero, or negative voltage to each strip. The lower body part is formed using a piezoelectric material poled in a first direction generally perpendicular to the channels and the upper body part is formed using a piezoelectric material also poled in the first direction. By applying a positive voltage to a first strip of conductive adhesive and a negative voltage to an adjacent strip of conductive adhesive, first and second electric fields oppositely orientated to each other and normal to the direction of poling are produced in the lower and upper body projections which form first and second sidewalls for the channel, thereby causing the first and second sidewalls to deform in first and second channel expanding directions, respectively.
摘要翻译： 喷墨打印头包括具有底部的下主体部分和从其向上延伸的多个大致平行的间隔开的突出部分，以及具有从其向下延伸的顶部部分和对应的多个大致平行间隔的突出部的上主体部分。 下体突起的顶侧导电地安装在上体突起的底侧，以形成限定多个墨载送通道的侧壁。 导电胶粘带将下部和上部主体突出物固定在一起，并且控制器电连接到条带以选择性地向每个条带施加正的，零的或负的电压。 下体部使用在大致垂直于通道的第一方向上极化的压电材料形成，并且使用也沿第一方向极化的压电材料形成上主体部。 通过向导电粘合剂的第一条带施加正电压并将负电压施加到相邻的导电粘合带上，在下部和上部主体突起中产生彼此相反定向并垂直于极化方向的第一和第二电场 其形成用于通道的第一和第二侧壁，从而分别使第一和第二侧壁在第一和第二通道扩张方向上变形。
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公开(公告)号：US5581286A
公开(公告)日：1996-12-03
申请号：US371888
申请日：1995-01-12
申请人： Donald J. Hayes , David B. Wallace
发明人： Donald J. Hayes , David B. Wallace
CPC分类号： B41J2/04581 , B23K26/389 , B23K26/40 , B41J2/0458 , B41J2/04593 , B41J2/14209 , B41J2/1433 , B41J2/2128 , B23K2203/52 , B41J2002/14379
摘要： A spot size modulatable, drop-on-demand type ink jet printhead and associated methods for ejecting volume modulatable droplets of ink therefrom. The ink jet printhead includes a main body portion having first and second ink carrying channels longitudinally extending therethrough and a cover plate fixedly mounted thereto. Formed in the cover plate is a tapered orifice which extends from first and second openings along a back side surface to a third opening along a front side surface thereof. The cover plate is mounted to the main body portion such that the first opening is in communication with the first ink carrying channel and the second opening is in communication with the second ink carrying channel. The ink jet printhead further includes first and second actuators coupled with the first and second ink carrying channels, respectively. Volume modulatable droplets of ink may be ejected from the ink jet printhead by simultaneously applying a voltage pulse having a selected magnitude to the first ink carrying channel and a voltage pulse having a magnitude ranging between zero and the selected magnitude to the second ink carrying channel. Alternately, volume modulatable droplets of ink may be ejected from the ink jet printhead by sequentially applying a voltage pulse having a selected time duration to the first ink carrying channel and a voltage pulse having a time duration ranging between zero and the selected time duration to the second ink carrying channel.
摘要翻译： 点尺寸可调节的按需喷墨打印头和用于从其中排出墨水的体积可调节液滴的相关方法。 喷墨打印头包括主体部分，其具有纵向延伸穿过其中的第一和第二墨水输送通道和固定地安装在其上的盖板。 在盖板中形成有锥形孔，其从第一和第二开口沿着背侧表面沿着其前侧表面延伸到第三开口。 盖板安装到主体部分，使得第一开口与第一墨水输送通道连通，第二开口与第二墨水输送通道连通。 喷墨打印头还包括分别与第一和第二墨水输送通道耦合的第一和第二致动器。 可以通过将具有选定幅度的电压脉冲同时施加到第一墨水承载通道和具有在零和所选大小之间的幅度范围的电压脉冲到第二墨水承载通道而从墨水喷射打印头喷射体积可调节墨水的墨滴。 或者，可以通过将具有选定持续时间的电压脉冲顺序地施加到第一墨水携带通道和具有从0到所选择的持续时间之间的持续时间范围的电压脉冲，从墨喷射打印头喷射体积可调节的墨水滴 第二墨水通道。
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公开(公告)号：US5433809A
公开(公告)日：1995-07-18
申请号：US149717
申请日：1993-11-09
申请人： John R. Pies , David B. Wallace , Donald J. Hayes
发明人： John R. Pies , David B. Wallace , Donald J. Hayes
CPC分类号： B41J2/1623 , B41J2/14209 , B41J2/1609 , B41J2/1618 , B41J2/1632 , B41J2002/14379 , Y10T156/1064 , Y10T156/1082 , Y10T29/42 , Y10T29/49401
摘要： Method for manufacturing a sidewall actuatable, high density channel array for an ink jet printhead. A first surface of a main body portion formed from an active material is conductively bonded to a first surface of a first intermediate body portion formed from an active material. A plurality of parallel grooves are then machined through the first intermediate body portion and part of the main body portion to form a plurality of channels separated by a corresponding plurality of sidewall actuators comprised of a first sidewall section formed from an active material and a second sidewall section formed from an active material. A top body portion is then conductively mounted to the intermediate body portion.
摘要翻译： 制造用于喷墨打印头的可侧壁致动的高密度通道阵列的方法。 由活性材料形成的主体部分的第一表面与由活性材料形成的第一中间体部分的第一表面导电地结合。 然后通过第一中间体部分和主体部分的一部分加工多个平行的凹槽，以形成由相应的多个侧壁致动器隔开的多个通道，该侧壁致动器包括由活性材料形成的第一侧壁部分和第二侧壁 由活性物质形成。 然后将顶部主体部分导电地安装到中间体部分。
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