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公开(公告)号：US06390453B1
公开(公告)日：2002-05-21
申请号：US09845714
申请日：2001-04-30
申请人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
发明人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
IPC分类号： B01F304
CPC分类号： B01F3/04049 , A61M11/001 , A61M11/042 , A61M15/02 , A61M15/025 , A61M2205/8206 , B01F3/022 , B01F15/0255 , F24F2003/1689 , Y10S261/65 , Y10S261/88
摘要： A method and apparatus is disclosed which employs a pulse-controlled microdroplet fluid delivery system for precisely dispensing fragrances and other odor producing vapors. The pulse-controlled fluid delivery device is capable of ejecting microdroplets of fluid with a diameter less than 350 micrometers at a controlled ejection rate based upon ink-jet printing technology. The pulse-controlled fluid delivery system includes mechanisms for vaporizing the fluids and delivery of the vapors to the nose, which is controlled by a programmable system controller capable of real time data-driven dispensing with a multi-fluid capability. Synthesis of custom fragrances is made possible by a multijet programmed control system which adjusts dispensing rates of components. Calibration of a prior art “electronic nose” is disclosed. A precise calibration gas is produced in real-time to counteract the effect of drifting.
摘要翻译： 公开了一种采用脉冲控制微滴流体输送系统来精确地分配香料和其它产生气味的蒸气的方法和装置。 脉冲控制流体输送装置能够以基于喷墨打印技术的受控喷射速率喷射直径小于350微米的流体微滴。 脉冲控制流体输送系统包括用于蒸发流体和将蒸气输送到鼻子的机构，其由可实时数据驱动分配多流体能力的可编程系统控制器控制。 通过调整组件的分配速率的多喷射编程控制系统可以实现定制香料的合成。 公开了现有技术的“电子鼻”的校准。 实时精确校准气体，以抵消漂移的影响。
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公开(公告)号：US06338715B1
公开(公告)日：2002-01-15
申请号：US09540836
申请日：2000-03-31
IPC分类号： A61B508
CPC分类号： A61B5/4011
摘要： A more reliable and precise method of determining the olfactory threshold is provided by a digitally operated apparatus that dispenses controlled amounts of a volatile test fluid from a digital jetting device of the type used for ink jet printing. A precise number and size of micro droplets are dispensed onto a heater which vaporizes the fluid at a test location where a patient can sniff and report whether the odor is sensed. Incremental adjustments are made to determine the approximate threshold of olfactory perception of the odor. Sensors are included to verify dispensing and to coordinate dispensing with breathing.
摘要翻译： 用于确定嗅觉阈值的更可靠和精确的方法由数字操作的装置提供，该装置从用于喷墨打印的类型的数字喷射装置中分配受控量的挥发性测试流体。 将精确数量和大小的微滴分配到加热器上，该加热器在患者可以窥视并报告是否检测到气味的测试位置使流体蒸发。 进行增量调整，以确定气味嗅觉的近似阈值。 包括传感器以验证分配并协调点胶呼吸。
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公开(公告)号：US06334851B1
公开(公告)日：2002-01-01
申请号：US09567915
申请日：2000-05-10
IPC分类号： A61B500
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2017/22089
摘要： A carrier film has one or more openings or wells loaded with a meltable absorbing substance for absorbing laser energy. The carrier film has a clear film which covers one side of the opening containing the absorber substance and the open side of the opening in the carrier film is positioned adjacent to the skin and irradiated through the clear cover film by a laser beam. The melted laser energy absorbing substance is ejected to form a spot laying on the skin. After moving the carrier film, a laser beam impinges the spot thereby raising a tiny blister on the skin containing interstitial fluid. The interstitial fluid is collected for diagnosis and analysis. A method of making and loading the carrier film with a digitally operated dispenser of the type used for ink jet printing is disclosed. Special construction of the opening appears to enhance ejection.
摘要翻译： 载体膜具有一个或多个装有可吸收吸收物质的开口或孔，用于吸收激光能量。 载体膜具有透明膜，其覆盖包含吸收体的开口的一侧，并且载体膜中的开口的开放侧定位成与皮肤相邻并且通过激光束透过透明覆盖膜照射。 熔化的激光能量吸收物质被喷射以形成铺在皮肤上的斑点。 在移动载体膜之后，激光束撞击斑点，从而在含有间质液的皮肤上引起微小的气泡。 收集间质液进行诊断和分析。 公开了一种使用用于喷墨印刷的数字操作的分配器来制造和加载载体膜的方法。 开幕式的特殊构造似乎增强了弹射。
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公开(公告)号：US06672129B1
公开(公告)日：2004-01-06
申请号：US10067224
申请日：2002-02-07
申请人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
发明人： Christopher J. Frederickson , Donald J. Hayes , David B. Wallace , David W. Taylor , Matthew D. Hayes
IPC分类号： G01N3700
CPC分类号： A61M15/02 , A61M11/041 , A61M15/008 , A61M15/025 , A61M16/0066 , A61M2205/332 , A61M2205/3375 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/8206 , B01F3/022 , B01F3/04049 , B01F15/0255 , F24F2003/1689
摘要： A method and apparatus is disclosed which employs a pulse-controlled microdroplet fluid delivery system for precisely dispensing fragrances and other odor producing vapors. The pulse-controlled fluid delivery device is capable of ejecting microdroplets of fluid with a diameter less than 350 micrometers at a controlled ejection rate based upon inkjet printing technology. The pulse-controlled fluid delivery system includes mechanisms for vaporizing the fluids and delivery of the vapors to the nose, which is controlled by a programmable system controller capable of real time data-driven dispensing with a multi-fluid capability. Synthesis of custom fragrances is made possible by a multijet programmed control system which adjusts dispensing rates of components. Calibration of a prior art “electronic nose” is disclosed. A precise calibration gas is produced in real-time to counteract the effect of drifting.
摘要翻译： 公开了一种采用脉冲控制微滴流体输送系统来精确地分配香料和其它产生气味的蒸气的方法和装置。 脉冲控制流体输送装置能够以基于喷墨打印技术的受控喷射速率喷射直径小于350微米的流体微滴。 脉冲控制流体输送系统包括用于蒸发流体和将蒸气输送到鼻子的机构，其由可实时数据驱动分配多流体能力的可编程系统控制器控制。 通过调整组件的分配速率的多喷射编程控制系统可以实现定制香料的合成。 公开了现有技术的“电子鼻”的校准。 实时精确校准气体，以抵消漂移的影响。
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5.发明授权Method for fabricating laminated carrier for collecting interstitial fluid from the skin 失效用于从皮肤收集组织液的层压载体的制造方法公开(公告)号：US06620283B1
公开(公告)日：2003-09-16
申请号：US09993489
申请日：2001-11-27
IPC分类号： B32B3128
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765 , A61B2017/22089
摘要： A method for making a laminated carrier film for use in releasing interstitial fluid from skin for collection or measurement includes providing a printhead having an orifice and a reservoir containing a meltable absorber substance, the printhead being capable in response to electrical signals, to eject droplets of said meltable absorber substance from the orifice; supporting a carrier film having a series of spaced apart openings for a meltable absorber substance on a support base, in close proximity to the printhead, whereby the spaced apart openings on the carrier film can be positioned relative to the orifice to receive absorber substance droplets ejected from the printhead; filling the spaced apart openings of the carrier film with meltable absorber substance ejected from the printhead; and covering the carrier film on one side with a clear polymer film strip selected to allow laser energy to pass through the clear polymer film in order to reach the meltable absorber substance inside the openings.
摘要翻译： 制备用于从皮肤释放组织液以进行收集或测量的层压载体膜的方法包括提供具有孔的打印头和包含可熔化吸收物质的储存器，该打印头能够响应于电信号而喷射液滴 所述可熔化的吸收剂物质来自孔口; 支撑载体膜，其具有一系列间隔开的开口，用于紧靠打印头的支撑基座上的可熔化吸收体，由此载体膜上的间隔开的开口可以相对于孔口定位，以接收喷射的吸收物质液滴 从打印头; 用从所述打印头喷射的可熔化的吸收体填充所述载体膜的间隔开的开口; 并且在一侧覆盖载体膜，其中所述透明聚合物膜条被选择为允许激光能量通过透明聚合物膜以便到达开口内部的可熔化吸收体。
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公开(公告)号：US06325475B1
公开(公告)日：2001-12-04
申请号：US08837646
申请日：1997-04-21
IPC分类号： B41J300
CPC分类号： A61M15/08 , A61B5/00 , A61B5/4011 , A61K49/1815 , A61L9/035 , A61L9/037 , A61M11/042 , A61M15/0011 , A61M15/0045 , A61M15/0048 , A61M15/025 , A61M2021/0016 , A61M2205/3306 , B24B49/003 , B41J3/00 , B41J3/4073
摘要： An ink-jet dispenser for the micro-dispensation of airborne materials into an individual's airspace for inhalation or sniffing. The ink-jet dispenser will allow the study of temporal integration times, inter-nostril summation, backwards and forwards masking, and other olfactory phenomena.
摘要翻译： 一种喷墨分配器，用于将空气传播材料微量分配到个人的空域用于吸入或嗅探。 喷墨分配器将允许研究时间积分时间，鼻孔总和，向后和向后掩蔽以及其他嗅觉现象。
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公开(公告)号：US5406319A
公开(公告)日：1995-04-11
申请号：US65920
申请日：1993-05-20
申请人： Donald J. Hayes , John R. Pies , David B. Wallace
发明人： Donald J. Hayes , John R. Pies , David B. Wallace
CPC分类号： B41J2/1632 , B41J2/14209 , B41J2/155 , B41J2/1609 , B41J2/1618 , B41J2/1623
摘要： The operation of U type drop-on-demand ink jet printheads are enhanced by selectively incorporating therein volume modifying tapers in the ink carrying channels, means for electrically isolating portions of the actuators thereof, and/or forming a variable layer of conductive material between the upper and lower sidewall portions therefore.
摘要翻译： U型按需喷墨打印头的操作通过选择性地将其中的油墨传送通道中的体积改变锥度，将其致动器的部分电隔离的装置和/或在其间形成可变的导电材料层来增强 因此上下侧壁部分。
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公开(公告)号：US4877745A
公开(公告)日：1989-10-31
申请号：US325037
申请日：1989-03-14
CPC分类号： G01N35/1095 , B01J19/0046 , B01J4/02 , B01L3/0268 , B82Y30/00 , G01F11/08 , G01F11/088 , B01J2219/00378 , B01J2219/00603 , B01J2219/00659 , B01J2219/00677 , C40B60/14 , G01N2035/1041 , Y10T436/2575
摘要： This invention relates to a system for printing and dispensing chemical reagents in precisely controlled volumes onto a medium at a precisely controlled location. A jetting tube, comprising an orifice at one end and a fluid receiving aperture at the other end, is concentrically mounted within a cylindrical piezo-electric transducer. The fluid receiving aperture is connected to a reservoir containing a selected reagent by means of a filter. The reservoir may be pressurized by a regulated air supply. An electrical signal of short duration is applied to the transducer. The pulse causes the transducer and the volume defined by the jetting tube to expand, thereby drawing in a small quantity of reagent fluid. The cessation of the pulse causes the transducer and the volume of the jetting tube to de-expand, thereby causing at least a substantially uniformly sized droplet of reagent fluid to be propelled through the orifice. The droplet may be directed to impact a printing medium or collected in a dispensing recepticle.
摘要翻译： 本发明涉及一种用于将精确控制体积的化学试剂印刷并分配到精确控制位置的介质上的系统。 一个包括一端的孔和另一端的流体接收孔的喷射管同心地安装在圆柱形的压电换能器内。 流体接收孔通过过滤器连接到容纳选定试剂的贮存器。 储存器可以通过调节空气供应来加压。 将短时间的电信号施加到换能器。 脉冲使得换能器和由喷射管限定的体积膨胀，从而抽取少量试液。 脉冲的停止导致换能器和喷射管的体积不扩张，从而使得至少基本上均匀大小的试剂流体的小滴通过孔被推进。 液滴可以被引导以冲击打印介质或者收集在分配容器中。
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公开(公告)号：US5658802A
公开(公告)日：1997-08-19
申请号：US524781
申请日：1995-09-07
IPC分类号： B01J19/00 , B01L3/02 , B01L99/00 , B41J3/407 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/543 , G01N35/10
CPC分类号： G01N33/54366 , B01J19/0046 , B01L3/0268 , B01L3/0293 , B41J3/407 , B82Y30/00 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00621 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00686 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N2035/1041
摘要： Arrays of electro-mechanical dispensers are used to form extremely small drops of fluid and locate them precisely on substrate surfaces in miniature arrays. The printed arrays may consist of DNA, immunoassay reagents or the like. A positioning support such as an X-Y table moves the dispensing devices and substrate surfaces relative to each other to locate the drops on the substrates in predetermined patterns. Arrays of probes as dense as one thousand per square centimeter with center-to-center spacing as small as twenty-five micrometers are formed.
摘要翻译： 电子机械分配器的阵列用于形成非常小的液滴，并将它们精确地定位在微型阵列的基板表面上。 印刷的阵列可以由DNA，免疫测定试剂等组成。 诸如X-Y台之类的定位支撑件相对于彼此移动分配装置和基板表面，以预定图案将液滴定位在基板上。 形成密度为千平方厘米的中心至中心间距小至二十五微米的探针阵列。
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公开(公告)号：US5554247A
公开(公告)日：1996-09-10
申请号：US420152
申请日：1995-04-11
申请人： John R. Pies , David B. Wallace , Donald J. Hayes
发明人： John R. Pies , David B. Wallace , Donald J. Hayes
CPC分类号： B41J2/1623 , B41J2/14209 , B41J2/1609 , B41J2/1618 , B41J2/1632 , B41J2002/14379 , Y10T156/1064 , Y10T156/1082 , Y10T29/42 , Y10T29/49401
摘要： Method for manufacturing a sidewall actuatable, high density channel array for an ink jet printhead. A first surface of a main body portion formed from an inactive material is conductively bonded to a first surface of a first intermediate body portion formed from an active material. A plurality of parallel grooves are then machined through the first intermediate body portion and part of the main body portion to form a plurality of channels separated by a corresponding plurality of sidewall actuators comprised of a first sidewall section formed from an inactive material and a second sidewall section formed from an active material. A top body portion is then conductively mounted to the intermediate body portion.
摘要翻译： 制造用于喷墨打印头的可侧壁致动的高密度通道阵列的方法。 由非活性材料形成的主体部分的第一表面导电结合到由活性材料形成的第一中间体部分的第一表面上。 然后通过第一中间体部分和主体部分的一部分加工多个平行的凹槽，以形成由相应的多个侧壁致动器隔开的多个通道，该侧壁致动器包括由非活性材料形成的第一侧壁部分和第二侧壁 由活性物质形成。 然后将顶部主体部分导电地安装到中间体部分。
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