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    Tool calibration system for micromachining system
    2.
    发明授权
    Tool calibration system for micromachining system 失效
    微加工系统工具校准系统

    公开(公告)号：US4142296A

    公开(公告)日：1979-03-06

    申请号：US860653

    申请日：1977-12-14

    申请人： Donald M. Miller

    发明人： Donald M. Miller

    IPC分类号： B23Q1/28 ,  B23Q1/48 ,  B23Q1/70 ,  B23Q17/22 ,  B24B13/04 ,  G01B7/00 ,  G01B7/28 ,  G12B13/00 ,  G01B5/00

    CPC分类号： B24B13/046 ,  B23Q1/28 ,  B23Q1/48 ,  B23Q1/70 ,  B23Q17/22 ,  B23Q17/2495 ,  G01B7/002 ,  G01B7/28 ,  G12B13/00 ,  Y10S82/90 ,  Y10T82/148

    摘要： A tool calibration system including a tool calibration fixture and a tool height and offset calibration insert for calibrating the position of a tool bit in a micromachining tool system. The tool calibration fixture comprises a yokelike structure having a triangular head, a cavity in the triangular head, and a port which communicates a side of the triangular head with the cavity. Yoke arms integral with the triangular head extend along each side of a tool bar and a tool head of the micromachining tool system. The yoke arms are secured to the tool bar to place the cavity around a tool bit which may be mounted to the end of the tool head. Three linear variable differential transformer's (LVDT) are adjustably mounted in the triangular head along an X axis, a Y axis, and a Z axis. The calibration insert comprises a main base which can be mounted in the tool head of the micromachining tool system in place of a tool holder and a reference projection extending from a front surface of the main base. Reference surfaces of the calibration insert and a reference surface on a tool bar standard length are used to set the three LVDT's of the calibration fixture to the tool reference position. These positions are transferred permanently to a mastering station. The tool calibration fixture is then used to transfer the tool reference position of the mastering station to the tool bit.

    摘要翻译： 刀具校准系统，包括刀具校准夹具和刀具高度和偏置校准刀片，用于校准微加工刀具系统中刀具位置。 工具校准夹具包括具有三角形头部，三角形头部中的空腔和将三角形头部的一侧与空腔连通的端口的袜形结构。 与三角头形成一体的轭形臂沿工具栏的两侧和微加工工具系统的工具头延伸。 轭臂固定到工具杆上，以将空腔围绕在可安装到工具头端部的工具头上。 三线式可变差动变压器（LVDT）可沿X轴，Y轴和Z轴可调安装在三角头中。 校准插入件包括可以安装在微加工工具系统的工具头中的主基座，以代替工具架和从主底座的前表面延伸的参考突起。 使用校准插入件的参考表面和工具栏标准长度上的参考表面将校准夹具的三个LVDT设置为刀具参考位置。 这些位置永久地转移到母盘台。 然后使用刀具校准夹具将母盘控制台的刀具参考位置传送到刀具位。

    Omega-X micromachining system
    3.
    发明授权
    Omega-X micromachining system 失效
    Omega-X微加工系统

    公开(公告)号：US4083272A

    公开(公告)日：1978-04-11

    申请号：US750317

    申请日：1976-12-14

    申请人： Donald M. Miller

    发明人： Donald M. Miller

    IPC分类号： B23Q1/28 ,  B23Q1/48 ,  B23Q1/70 ,  B23Q17/22 ,  B24B13/04 ,  G01B7/00 ,  G01B7/28 ,  G12B13/00 ,  B23B5/36 ,  B23B5/40

    CPC分类号： B24B13/046 ,  B23Q1/28 ,  B23Q1/48 ,  B23Q1/70 ,  B23Q17/22 ,  B23Q17/2495 ,  G01B7/002 ,  G01B7/28 ,  G12B13/00 ,  Y10S82/90 ,  Y10T82/148

    摘要： A micromachining tool system with X- and omega-axes is used to machine spherical, aspherical, and irregular surfaces with a maximum contour error of 100 nonometers (nm) and surface waviness of no more than 0.8 nm RMS. The omega axis, named for the angular measurement of the rotation of an eccentric mechanism supporting one end of a tool bar, enables the pulse increments of the tool toward the workpiece to be as little as 0 to 4.4 nm. A dedicated computer coordinates motion in the two axes to produce the workpiece contour. Inertia is reduced by reducing the mass pulsed toward the workpiece to about one-fifth of its former value. The tool system includes calibration instruments to calibrate the micromachining tool system. Backlash is reduced and flexing decreased by using a rotary table and servomotor to pulse the tool in the omega-axis instead of a ball screw mechanism. A thermally-stabilized spindle rotates the workpiece and is driven by a motor not mounted on the micromachining tool base through a torque-smoothing pulley and vibrationless rotary coupling. Abbe offset errors are almost eliminated by tool setting and calibration at spindle center height. Tool contour and workpiece contour are gaged on the machine; this enables the source of machining errors to be determined more readily, because the workpiece is gaged before its shape can be changed by removal from the machine.

    摘要翻译： 具有X-和ω-轴的微加工工具系统用于加工球面，非球面和不规则表面，其最大轮廓误差为100个不计（nm），表面波纹不超过0.8nm RMS。 称为用于角度测量支撑工具杆一端的偏心机构的旋转的ω轴，使得刀具朝向工件的脉冲增量可以低至0至4.4nm。 一个专用的计算机在两个轴上坐标运动以产生工件轮廓。 通过将朝向工件脉冲的质量减小到其前值的约五分之一来减小惯量。 该工具系统包括用于校准微加工工具系统的校准仪器。 通过使用旋转工作台和伺服电机将ω-轴上的工具代替滚珠丝杠机构来减小和弯曲齿隙。 热稳定的主轴旋转工件，并由未安装在微加工工具基座上的电机通过扭矩平滑滑轮和无振动的旋转联轴器驱动。 主轴中心高度的刀具设置和校准几乎消除了阿贝偏移误差。 刀具轮廓和工件轮廓在机器上进行加工; 这使得能够更容易地确定加工误差源，因为在通过从机器移除之前可以改变工件的形状之前对其进行计量。

    Compositions and Methods for Treating Cancer, Inhibiting Proliferation, and Inducing Cell Death
    4.
    发明申请
    Compositions and Methods for Treating Cancer, Inhibiting Proliferation, and Inducing Cell Death 有权
    治疗癌症，抑制增殖和诱导细胞死亡的组合物和方法

    公开(公告)号：US20110213019A1

    公开(公告)日：2011-09-01

    申请号：US13063509

    申请日：2009-09-11

    申请人： Donald M. Miller ,  Shelia Diann Thomas ,  Kara Joyce Sedoris

    发明人： Donald M. Miller ,  Shelia Diann Thomas ,  Kara Joyce Sedoris

    IPC分类号： A61K31/7088 ,  C12N5/09 ,  A61P35/00 ,  A61P35/02

    CPC分类号： A61K31/7088

    摘要： Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a patient are provided, including (i) a safe and effective amount of a sequence having at least 80% nucleic acid identity with a guanine-rich promoter gene oligonucleotide (GPGO), and (ii) a carrier, wherein the oligonucleotide forms at least one quadruplex.

    摘要翻译： 富含四肽的富含鸟嘌呤的核酸序列可用于抑制细胞生长和增殖并诱导细胞死亡的组合物和方法。 提供用于治疗患者的组合物，其包括（i）安全有效量的与富含鸟嘌呤的启动子基因寡核苷酸（GPGO）具有至少80％的核酸同一性的序列，和（ii）载体，其中寡核苷酸 形成至少一个quadruplex。

    Breathing apparatus
    8.
    发明授权
    Breathing apparatus 失效
    呼吸设备

    公开(公告)号：US5311861A

    公开(公告)日：1994-05-17

    申请号：US961453

    申请日：1992-10-15

    申请人： Donald M. Miller

    发明人： Donald M. Miller

    IPC分类号： A61M16/08 ,  A61M16/00

    CPC分类号： A61M16/08 ,  Y10S128/909 ,  Y10S128/912

    摘要： The breathing apparatus disclosed includes a first connector structure which provides ports for connection to a supply of fresh breathing gases, to an afferent gas tube and to an afferent gas bag. The first connector structure also provides a port to which a ventilator can be connected, a port to which an efferent gas tube can be connected, and a connection to an efferent gas bag. The afferent gas tube is of larger diameter than the efferent gas tube. The apparatus further includes a second connector construction to which said tubes are connected and which has a port for connection to the patient. The second connector structure causes preferential flow between the patient port and the afferent gas tube port.

    摘要翻译： 所公开的呼吸装置包括第一连接器结构，其提供用于连接到新鲜呼吸气体源的端口，传送气体管和传入气囊。 第一连接器结构还提供了可以连接呼吸机的端口，可以连接传出气体管的端口和与传出气囊的连接。 传入气管的直径大于传出气管的直径。 该装置还包括第二连接器结构，所述管连接到该第二连接器结构，并且具有用于连接到患者的端口。 第二连接器结构导致患者端口和传入气管端口之间的优先流动。

    Motion transmitting remote control assembly
    9.
    发明授权
    Motion transmitting remote control assembly 失效
    运动遥控装置

    公开(公告)号：US4173157A

    公开(公告)日：1979-11-06

    申请号：US896319

    申请日：1978-04-14

    申请人： Donald M. Miller ,  Grant A. Webb

    发明人： Donald M. Miller ,  Grant A. Webb

    IPC分类号： F16C1/20 ,  F16C1/26 ,  F16C11/06 ,  F16C1/10

    CPC分类号： F16C1/265 ,  F16C1/107 ,  Y10T74/2042

    摘要： A motion transmitting remote control assembly of the type for transmitting forces along a curved path by a flexible motion transmitting core element movably supported within a conduit. The core element is a stranded cable-like member having a first end extending from a support member secured to the conduit and supported by a support structure. A terminal member is disposed on the end of the core element and is operatively attached to a control member. The support member includes a male spherical end portion and a wiper means comprising a female spherical member is snapped onto the male spherical portion for swivelling movement. The female spherical member is in wiping engagement with the core element for preventing foreign matter on the extended length of the core element from entering into the conduit upon movement of the core element while at the same time allows the axis of the extended length of the core element to move in a conical area.

    摘要翻译： 一种用于通过可移动地支撑在导管内的柔性运动传递芯元件沿弯曲路径传递力的类型的运动发射遥控组件。 所述芯元件是绞合的电缆状构件，其具有从固定到所述导管并由支撑结构支撑的支撑构件延伸的第一端。 端子构件设置在芯元件的端部上并且可操作地附接到控制构件。 支撑构件包括阳性球形端部，并且包括阴性球形构件的擦拭器装置卡扣在阳性球形部分上用于旋转运动。 雌性球形构件与芯元件擦拭接合，用于防止芯元件的延伸长度上的异物在芯元件移动时进入导管，同时允许芯的延伸长度的轴线 元件在圆锥形区域中移动。