公开(公告)号：US5621780A

公开(公告)日：1997-04-15

申请号：US507845

申请日：1995-07-27

申请人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte

发明人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte

IPC分类号： G21K5/02 ,  A61B1/00 ,  A61N5/10 ,  G01N23/083 ,  G21K5/00 ,  G21K5/04 ,  G21K5/10 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

CPC分类号： A61N5/1001 ,  G21K5/04 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61N2005/1005 ,  H01J2201/342

摘要： The present invention is directed to an x-ray source for irradiating a surface defining a body cavity in accordance with a predetermined dose distribution. The source comprises a housing, an elongated tubular probe, a target assembly, and an inflatable balloon. The housing encloses an electron beam source and includes elements for generating an electron beam along a beam path. The tubular probe extends along a central axis from the housing about the beam path. The target assembly extends along the central axis and is coupled to the end of the probe distal from the housing. The target assembly includes a target element is positioned in the beam path. The target element is adapted to emit x-rays in response to electrons incident thereon from the beam. The probe tip assembly and associated control electronics include elements for positioning the target element in the beam path, and is substantially x-ray transparent. The balloon is affixed to the distal end of the probe and is inflatable so that when that probe end is inserted into a body cavity, the balloon may be inflated to stretch the cavity to a known shape. Positioning the probe tip inside the inflated balloon allows delivery of a uniform, or other desired, dose of radiation to the surface defining a body cavity.

摘要翻译： 本发明涉及一种用于根据预定剂量分布照射限定体腔的表面的X射线源。 源包括壳体，细长管状探针，靶组件和可充气球囊。 壳体包围电子束源并且包括用于沿着光束路径产生电子束的元件。 管状探针沿着中心轴线从壳体围绕光束路径延伸。 目标组件沿着中心轴线延伸并且远离壳体耦合到探针的端部。 目标组件包括目标元件位于光束路径中。 目标元件适于响应于从光束入射到其上的电子而发射X射线。 探针尖端组件和相关联的控制电子器件包括用于将目标元件定位在光束路径中的元件，并且基本上是x射线透明的。 气囊固定在探头的远端，并且是可充气的，使得当该探针端插入体腔时，气囊可被充气以将空腔拉伸到已知形状。 将探针尖端定位在充气球囊内部允许将均匀的或其它所需剂量的辐射传送到限定体腔的表面。

公开(公告)号：US5422926A

公开(公告)日：1995-06-06

申请号：US184271

申请日：1994-01-21

申请人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Mark T. Dinsmore

发明人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Mark T. Dinsmore

IPC分类号： A61B19/00 ,  A61N5/10 ,  H01B11/22 ,  H01J35/00 ,  H01J35/06 ,  H01J35/08 ,  H01J35/14 ,  H01J35/30 ,  H01J35/32 ,  H05G1/00 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

CPC分类号： A61N5/1001 ,  A61B90/11 ,  H01J35/065 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61B2090/101 ,  A61N2005/1005 ,  H01J2201/342

摘要： The present invention is directed to an x-ray source for irradiating a volume in accordance with a predetermined dose distribution. The source comprises a housing, an elongated tubular probe, and a target assembly. The housing encloses an electron beam source and includes elements for generating an electron beam along a beam path. The tubular probe extends along a central axis from the housing about the beam path. The target assembly extends along the central axis and is adapted for coupling to the end of the probe distal from the housing. The target assembly includes a target element, a probe tip assembly, and a variable transmission shield. The target element is positioned in the beam path. The target element is adapted to emit x-rays in response to electrons incident thereon from the beam. The probe tip assembly and associated control electronics include elements for positioning the target element in the beam path, and is substantially x-ray transparent. The variable transmission shield is positioned on an outer surface of the probe tip assembly, and is adapted to control the position of the isodose surfaces of the x-rays emitted from the target and passing through the probe tip assembly.

摘要翻译： 本发明涉及一种用于根据预定剂量分布照射体积的x射线源。 源包括壳体，细长管状探针和目标组件。 壳体包围电子束源并且包括用于沿着光束路径产生电子束的元件。 管状探针沿着中心轴线从壳体围绕光束路径延伸。 目标组件沿着中心轴线延伸并且适于联接到远离壳体的探针的端部。 目标组件包括目标元件，探针尖端组件和可变透射屏蔽。 目标元件位于光束路径中。 目标元件适于响应于从光束入射到其上的电子而发射X射线。 探针尖端组件和相关联的控制电子器件包括用于将目标元件定位在光束路径中的元件，并且基本上是x射线透明的。 可变透射屏蔽定位在探针头组件的外表面上，并且适于控制从靶发射并穿过探针头组件的X射线的等剂量表面的位置。

公开(公告)号：US5566221A

公开(公告)日：1996-10-15

申请号：US273963

申请日：1994-07-12

申请人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Robert A. Roth

发明人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Robert A. Roth

IPC分类号： A61B17/22 ,  A61N5/10

CPC分类号： A61N5/1001 ,  A61N5/1014 ,  A61B2017/22068 ,  A61M2025/1047

摘要： The present invention is directed to a kit for delivering x-rays to the interior surface of a body cavity. The kit includes an x-ray source and an x-ray source guidance tube. The guidance tube includes an inflatable inelastic balloon disposed about and affixed at its distal end such that when inflated, the central axis of the balloon is coaxial with and is disposed about the central axis of the tubular element. Inflation and deflation of the balloon is controllable from the proximal end of the tubular element. The x-ray source may include an electron activated target for generating x-rays in response to electrons incident on the target. The x-ray source may also includes means for generating an electron beam and steering the beam so that it is incident on the target. The target end is slidably positionable within an interior channel of the source guidance tube.

摘要翻译： 本发明涉及一种用于将X射线输送到体腔内表面的试剂盒。 该套件包括一个x射线源和一个x射线源引导管。 引导管包括可膨胀的非弹性球囊，其设置在其远端周围并固定在其远端，使得当膨胀时，球囊的中心轴线与管状元件的中心轴线同轴并且围绕管状元件的中心轴线设置。 从管状元件的近端可以控制气囊的充气和放气。 X射线源可以包括用于响应于入射到靶上的电子而产生X射线的电子激活靶。 X射线源还可以包括用于产生电子束并转向光束以使其入射到靶上的装置。 目标端可滑动地定位在源引导管的内部通道内。

公开(公告)号：US5452720A

公开(公告)日：1995-09-26

申请号：US104338

申请日：1993-08-09

申请人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Peter J. Biggs ,  John F. Beatty

发明人： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Peter J. Biggs ,  John F. Beatty

IPC分类号： A61N5/10 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61B6/12 ,  A61M36/00

CPC分类号： A61N5/1001 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61N2005/1005 ,  H01J2201/342

摘要： A method of treating brain tumors in a patient, comprising the steps of: identifying and locating a brain tumor in vivo by affixing a stereotactic frame to the head of the patient, performing a computer tomographic (CT) scan of the skull of the patient to determine the location, size, and shape of the tumor with respect to the stereotactic frame, performing a biopsy by inserting an extraction tool along a path measured with respect to the frame to the tumor location, extracting a tissue from the location, removing the needle and the extracted tissue and analyzing the tissue; implanting at least a portion of an adjustable x-ray radiation source in the patient proximate the tumor, the adjustable radiation source including an electron beam source outside the head of the patient, and directing an electron beam produced by the source outside the head of the patient along the path to the location; and controlling the source to generate an x-ray radiation pattern characterized by a spatial and temporal distribution, to selectively irradiate the tumor.

摘要翻译： 一种治疗患者脑肿瘤的方法，包括以下步骤：通过将立体定向框架固定在患者的头部来识别和定位脑肿瘤，对患者的头骨进行计算机断层扫描（CT）扫描 确定相对于立体定向框架的肿瘤的位置，大小和形状，通过沿着相对于框架测量的路径将提取工具插入到肿瘤位置进行活检，从该位置提取组织，移除针 和提取的组织并分析组织; 在靠近肿瘤的患者中植入至少一部分可调节X射线辐射源，所述可调节辐射源包括位于患者头部外部的电子束源，并且将源头产生的电子束引导到患者头部外部 患者沿着路径到位置; 并且控制源以产生以空间和时间分布为特征的X射线辐射图，以选择性地照射肿瘤。

公开(公告)号：US06421416B1

公开(公告)日：2002-07-16

申请号：US09502759

申请日：2000-02-11

申请人： Alan P. Sliski ,  Kenneth J. Harte

发明人： Alan P. Sliski ,  Kenneth J. Harte

IPC分类号： A61N510

CPC分类号： A61N5/1001 ,  A61N2005/1022 ,  A61N2005/1095

摘要： A radiation applicator system is structured to be mounted to a radiation source for producing a predefined dose of radiation for treating a localized volume of tissue, such as the tissue surrounding the site of an excised tumor. The applicator system includes an applicator and, in some embodiments, an adapter. The adapter is formed for fixedly securing the applicator to a radiation source, such as the x-ray source of a radiosurgery system which produces a predefined radiation dose profile with respect to a predefined location along its radiation producing probe. The applicator includes a shank and an applicator head, wherein the head is located at a distal end of the applicator shank. A proximate end of the applicator shank couples to the adapter. A distal end of the shank includes the applicator head, which defines a concave treatment surface for engaging and, preferably, supporting the area to be treated with a predefined does of radiation. The applicator can include a low energy radiation filter inside of the applicator head to reduce undesirable low energy radiation emissions. A plurality of applicators having applicator heads of different sizes and shapes can be provided to accommodate treatment sites of various sizes and shapes. And, an adaptable applicator having a plurality of radiation positions can be provided to deliver a substantially cylindrical dose of radiation.

摘要翻译： 辐射施加器系统被构造成安装到辐射源，以产生用于治疗局部体积的组织的预定剂量的辐射，例如围绕切除的肿瘤部位的组织。 施用器系统包括施加器，并且在一些实施例中包括适配器。 适配器被形成用于将施加器固定地固定到辐射源，例如放射外科系统的x射线源，其相对于沿其辐射产生探针的预定位置产生预定的辐射剂量分布。 施用器包括柄和施用器头，其中头位于施用器柄的远端。 施加器柄的近端耦合到适配器。 柄的远端包括施用器头，其限定凹入的处理表面，用于接合并且优选地以预定的辐射功率来支撑待处理的区域。 施用器可以在施用头内部包括低能量辐射过滤器，以减少不期望的低能量辐射发射。 可以提供具有不同尺寸和形状的施用器头的多个施用器以适应各种尺寸和形状的处理部位。 并且，可以提供具有多个辐射位置的适应性施加器以递送基本上圆柱形的辐射剂量。

公开(公告)号：US06301328B1

公开(公告)日：2001-10-09

申请号：US09502273

申请日：2000-02-11

申请人： Alan P. Sliski ,  Kenneth J. Harte

发明人： Alan P. Sliski ,  Kenneth J. Harte

IPC分类号： A61N510

CPC分类号： A61N5/1017 ,  A61N5/1001 ,  A61N2005/1094

摘要： A radiation applicator system is structured to be mounted to a radiation source for producing a beam of radiation for treating a localized volume of tissue, such as growing blood vessels in the eye that can cause macular degeneration. The applicator system includes an applicator and, in some embodiments, an adapter. The adapter is formed for fixedly securing the applicator to a radiation source, such as a radiosurgery system which produces a predefined radiation dose profile with respect to a predefined location along the radiation producing probe. The applicator includes a shank and an applicator head. A proximate end of the applicator shank couples to the adapter. A distal end of the shank includes the applicator head, which is adapted to produce a beam of radiation. The applicator head includes a radiation shield and a beam collimator. The radiation shield selectively blocks the emitted radiation so that the applicator can be held by a surgeon during treatment. The beam collimator extends from an aperture in the shield that forms and directs a beam of radiation at a target area. Applicator systems that form different size and shape beams of radiation can be provided to accommodate a wide range of treatment volumes and for use in different treatments.

摘要翻译： 辐射施加器系统被构造成安装到辐射源，用于产生用于治疗局部体积的组织的放射线束，例如在眼睛中生长的可导致黄斑变性的血管。 施用器系统包括施加器，并且在一些实施例中包括适配器。 适配器被形成用于将施加器固定地固定到辐射源，例如放射外科系统，其相对于沿辐射产生探针的预定位置产生预定的辐射剂量分布。 施用器包括柄和施用头。 施加器柄的近端耦合到适配器。 柄的远端包括施加头，其适于产生辐射束。 施用器头包括辐射屏蔽和射束准直器。 辐射屏蔽选择性地阻挡发射的辐射，使得施用器可以在治疗期间被外科医生保持。 光束准直器从屏蔽中的孔延伸，其形成并引导目标区域的辐射束。 可以提供形成不同尺寸和形状的辐射束的施放器系统以适应宽范围的处理量并用于不同的处理。

公开(公告)号：US06285735B1

公开(公告)日：2001-09-04

申请号：US09505413

申请日：2000-02-11

申请人： Alan P. Sliski ,  Kenneth J. Harte

发明人： Alan P. Sliski ,  Kenneth J. Harte

IPC分类号： A61N510

CPC分类号： A61N5/1001

摘要： A radiation applicator system is structured to be mounted to a radiation source for providing a predefined dose of radiation for treating a localized volume of tissue, such as the tissue surrounding the site of an excised tumor. The applicator system includes an applicator and, in some embodiments, an adapter. The adapter is formed for fixedly securing the applicator to a radiation source, such as a radiosurgery system which produces a predefined radiation dose profile with respect to a predefined location along its radiation producing probe. The applicator includes a shank and an end cap, wherein the end cap includes a substantially flat or convex treatment surface and is located at a distal end of the applicator shank. A proximate end of the applicator shank couples to the adapter. A distal end of the shank includes the end cap, which is adapted for engaging and preferably supporting the area to be treated with a predefined does of radiation. The applicator can include a low energy radiation filter inside of the applicator end cap to reduce undesirable low energy radiation emissions. A plurality of applicators having end caps of different sizes and shapes can be provided to accommodate treatment sites of various sizes and shapes. And, an adaptable applicator having a plurality of radiation positions can be provided to deliver a substantially cylindrical dose of radiation.

摘要翻译： 辐射施加器系统被构造成安装到辐射源，以提供预定剂量的辐射来治疗局部体积的组织，例如围绕切除的肿瘤部位的组织。 施用器系统包括施加器，并且在一些实施例中包括适配器。 适配器被形成用于将施用器固定地固定到辐射源，例如放射外科系统，其相对于沿其辐射产生探针的预定位置产生预定的辐射剂量分布。 施用器包括柄和端盖，其中端盖包括基本平坦或凸起的处理表面并且位于施用器柄的远端。 施加器柄的近端耦合到适配器。 柄的远端包括端盖，该端盖适于接合并且优选地以预定的辐射功率来支撑待处理的区域。 施加器可以在施加器端盖内部包括低能量辐射过滤器，以减少不期望的低能量辐射发射。 可以提供具有不同尺寸和形状的端盖的多个施加器以适应各种尺寸和形状的处理部位。 并且，可以提供具有多个辐射位置的适应性施加器以递送基本上圆柱形的辐射剂量。

公开(公告)号：US07109505B1

公开(公告)日：2006-09-19

申请号：US09502762

申请日：2000-02-11

申请人： Alan P. Sliski ,  Kenneth J. Harte

发明人： Alan P. Sliski ,  Kenneth J. Harte

IPC分类号： G02B5/00

CPC分类号： A61N5/1015 ,  A61B6/08 ,  A61N5/1001 ,  A61N2005/1094

摘要： A radiation applicator system is structured to be mounted to a radiation source for providing a predefined dose of radiation for treating a localized area or volume, such as the tissue surrounding the site of an excised tumor. The applicator system includes an applicator and an adapter. The adapter is formed for fixedly securing the applicator to a radiation source, such as a radiosurgery system which produces a predefined radiation dose profile with respect to a predefined location along the radiation producing probe. The applicator includes a shank and an applicator head, wherein the head is located at a distal end of the applicator shank. A proximate end of the applicator shank couples to the adapter. A distal end of the shank includes the applicator head, which is adapted for engaging and/or supporting the area or volume to be treated with a predefined does of radiation. The applicator can include a low energy radiation filter inside of the applicator head to reduce undesirable low energy radiation emissions. A biocompatible radiation shield may be coupled to the outer surface of the applicator head to block radiation emitted from a portion of the radiation probe, in order to shield an adjacent location or vital organ from any undesired radiation exposure. A plurality of applicators having applicator heads and radiation shields of different sizes and shapes can be provided to accommodate treatment sites of various sizes and shapes.

摘要翻译： 辐射施加器系统构造成安装到辐射源，以提供用于治疗局部区域或体积的预定剂量的辐射，例如围绕切除的肿瘤部位的组织。 涂抹器系统包括涂敷器和适配器。 适配器被形成用于将施加器固定地固定到辐射源，例如放射外科系统，其相对于沿辐射产生探针的预定位置产生预定的辐射剂量分布。 施用器包括柄和施用器头，其中头位于施用器柄的远端。 施加器柄的近端耦合到适配器。 柄的远端包括施用器头，其适于用预定义的辐射来接合和/或支撑待处理的区域或体积。 施用器可以在施用头内部包括低能量辐射过滤器，以减少不期望的低能量辐射发射。 生物相容的辐射屏蔽可以耦合到施用器头的外表面以阻挡从辐射探针的一部分发射的辐射，以便屏蔽相邻位置或重要器官免受任何不期望的辐射照射。 可以提供具有不同尺寸和形状的施用器头和辐射屏蔽的多个施加器以适应各种尺寸和形状的治疗部位。

公开(公告)号：US4661709A

公开(公告)日：1987-04-28

申请号：US749792

申请日：1985-06-28

申请人： David M. Walker ,  Alan P. Sliski ,  Kenneth J. Harte ,  John J. Carrona

发明人： David M. Walker ,  Alan P. Sliski ,  Kenneth J. Harte ,  John J. Carrona

IPC分类号： H01J37/30 ,  H01J37/317 ,  H01J3/38

CPC分类号： B82Y10/00 ,  B82Y40/00 ,  H01J37/3007 ,  H01J37/3177

摘要： The invention provides a modular-building block method and system of fabrication, installation, alignment and operation of a multi-beam assembly of miniaturized, all-electrostatic charged particle optical columns, such electron beam or ion beam optical columns mounted in parallel in a closely packed cluster over a small target surface area for parallel simultaneous charged particle beam writing on the target surface with the multiple-channel cluster of charged particle beam optical columns. The assembly provides a system and method of increased thru-put in the direct charged particle beam writing on semiconductor target wafers during fabrication of semiconductor micro-circuit chips.

摘要翻译： 本发明提供了一种用于小型化，全静电带电粒子光学柱的多光束组件的制造，安装，对准和操作的模块化构建块方法和系统，这种电子束或离子束光学柱被紧密地安装 在小目标表面区域上的堆叠簇，用于并行同时带电的粒子束在目标表面上与带有带电粒子束光柱的多通道簇一起写入。 该组件提供了在制造半导体微电路芯片期间在半导体靶晶片上的直接带电粒子束写入中增加通量的系统和方法。

公开(公告)号：US06302581B1

公开(公告)日：2001-10-16

申请号：US09502473

申请日：2000-02-11

申请人： Alan P. Sliski ,  Kenneth J. Harte

发明人： Alan P. Sliski ,  Kenneth J. Harte

IPC分类号： H05G102

CPC分类号： A61N5/1001 ,  A61N5/01 ,  Y10S212/901

摘要： A support system for a radiation treatment system includes a rotatable extension arm extending from a vertical shaft and a rotatable counterbalance extending diametrically opposed to the extension arm from the vertical shaft. The vertical shaft is rotatably supported by a support base. The support base may include a damping mechanism to damp the rotational motion of the vertical shaft relative to the support base, wherein the damping force is preferably proportional to the velocity of the vertical shaft. The radiation treatment system is suspended from a cable extending from a distal end of the extension arm. The extension arm can be formed from a first arm extending from the vertical shaft and a second arm rotatably coupled to the first arm in order to permit the radiation treatment system to be moved in horizontal direction. The cable supporting the radiation treatment system can be coupled to a vertical counterbalance weight to allow the vertical position of the radiation treatment system to be adjusted. In addition, mass of the vertical counterbalance weight can be adjusted to compensate for attachments which may be used with the radiation treatment system during treatment. The radiation treatment system can be supported to permit rotation about a horizontal axis that extends through the center of mass of the radiation treatment system. In addition position of the horizontal axis of rotation relative to the center of mass of the radiation treatment system can be adjusted to compensate for attachments which may change the center of mass of the radiation treatment system.

摘要翻译： 用于放射线治疗系统的支撑系统包括从垂直轴延伸的可旋转的延伸臂和从垂直轴与延伸臂径向相对延伸的可旋转平衡物。 垂直轴由支撑基座可旋转地支撑。 支撑基座可以包括阻尼机构，以阻止垂直轴相对于支撑基座的旋转运动，其中阻尼力优选地与垂直轴的速度成比例。 辐射处理系统从延伸臂的远端延伸的电缆悬挂。 延伸臂可以由从垂直轴延伸的第一臂和可旋转地联接到第一臂的第二臂形成，以允许辐射处理系统在水平方向上移动。 支撑辐射处理系统的电缆可以连接到垂直平衡重，以允许辐射处理系统的垂直位置被调节。 此外，可以调整垂直平衡重量的质量以补偿在处理期间可能与辐射处理系统一起使用的附件。 辐射处理系统可以被支撑以允许围绕延伸穿过辐射处理系统的质心的水平轴旋转。 相对于辐射处理系统的质心的水平旋转轴线的位置可以被调整以补偿可能改变辐射处理系统的质心的附件。