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1.发明授权
公开(公告)号：US5132463A
公开(公告)日：1992-07-21
申请号：US713895
申请日：1991-06-12
申请人： Donald W. Graham , John C. Chabala , Tesfaye Biftu , Michael N. Chang , Yuan-Ching P. Chiang , Shu S. Yang , Kathryn L. Thompson
发明人： Donald W. Graham , John C. Chabala , Tesfaye Biftu , Michael N. Chang , Yuan-Ching P. Chiang , Shu S. Yang , Kathryn L. Thompson
IPC分类号： C07C43/21 , C07C43/215 , C07C43/225 , C07C43/23 , C07C45/45 , C07C45/48 , C07C49/753 , C07C59/72 , C07C317/14 , C07C317/22 , C07C323/62
CPC分类号： C07C255/00 , C07C323/00 , C07C323/62 , C07C43/21 , C07C43/215 , C07C43/225 , C07C43/23 , C07C45/45 , C07C45/48 , C07C49/753 , C07C59/72 , C07C2101/08
摘要： Novel 1,3-Diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.
摘要翻译： 制备以下通式的新型1,3-二芳基环戊烷。 （I）发现这些化合物具有有效和特异的PAF（血小板活化因子）拮抗活性，因此可用于治疗或改善由PAF介导的各种疾病或病症，例如低血压，炎症，肾炎 ，中风和其他心血管疾病，哮喘，过敏性和皮肤疾病，消化性溃疡或胃溃疡，休克，肺水肿，牛皮癣，成人呼吸窘迫综合征，包括牙痛的疼痛和血小板聚集。
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2.发明授权
公开(公告)号：US5047420A
公开(公告)日：1991-09-10
申请号：US396489
申请日：1989-08-21
申请人： Donald W. Graham , Tesfaye Biftu , John C. Chabala , Michael N. Chang , Yuan-Ching P. Chiang , Kathryn L. Thompson , Shu S. Yang
发明人： Donald W. Graham , Tesfaye Biftu , John C. Chabala , Michael N. Chang , Yuan-Ching P. Chiang , Kathryn L. Thompson , Shu S. Yang
IPC分类号： C07C323/62
CPC分类号： C07C323/62 , C07C2101/08
摘要： Novel 1,3-diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediate by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.
摘要翻译： 制备以下通式的新型1,3-二芳基环戊烷。 （I）发现这些化合物具有有效和特异性的PAF（血小板活化因子）拮抗活性，因此可用于治疗或改善由PAF介导的各种疾病或病症，例如低血压，炎症，肾炎 ，中风和其他心血管疾病，哮喘，过敏性和皮肤疾病，消化性溃疡或胃溃疡，休克，肺水肿，牛皮癣，成人呼吸窘迫综合征，包括牙痛的疼痛和血小板聚集。
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公开(公告)号：US5120729A
公开(公告)日：1992-06-09
申请号：US540992
申请日：1990-06-20
申请人： John C. Chabala , Michael N. Chang , Yuan-Ching P. Chiang , James V. Heck , Kathryn L. Thompson , Shu S. Yang
发明人： John C. Chabala , Michael N. Chang , Yuan-Ching P. Chiang , James V. Heck , Kathryn L. Thompson , Shu S. Yang
IPC分类号： A61K31/395 , A61K31/397 , A61P3/06 , A61P9/10 , A61P43/00 , C07D205/08 , C12N9/99
CPC分类号： C07D205/08
摘要： This application relates to compounds of formula (I), which are useful as antihypercholesterolemic agents. ##STR1##
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公开(公告)号：US4847271A
公开(公告)日：1989-07-11
申请号：US21848
申请日：1987-03-04
申请人： John C. Chabala , Yuan-Ching P. Chiang , Michael N. Chang , Narindar M. Girotra , Donald W. Graham , Shu S. Yang
发明人： John C. Chabala , Yuan-Ching P. Chiang , Michael N. Chang , Narindar M. Girotra , Donald W. Graham , Shu S. Yang
IPC分类号： A61K31/335 , A61K31/337 , A61K31/365 , A61P3/06 , C07D305/12 , C07D405/12
CPC分类号： C07D405/12 , A61K31/365 , C07D305/12
摘要： The compounds of the following general structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
摘要翻译： 以下一般结构式（I）的化合物（I）是3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）合酶抑制剂，可用作抗高胆固醇血症药物，用于治疗其中抑制 胆固醇生物合成将是有用的，例如动脉硬化，高脂血症和家族性高胆固醇血症。
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公开(公告)号：US4806564A
公开(公告)日：1989-02-21
申请号：US53774
申请日：1987-05-26
申请人： John C. Chabala , Yuan-Ching P. Chiang , Michael N. Chang , Donald W. Graham , James V. Heck , Shu S. Yang
发明人： John C. Chabala , Yuan-Ching P. Chiang , Michael N. Chang , Donald W. Graham , James V. Heck , Shu S. Yang
IPC分类号： A61K31/337 , A61K31/365 , A61P3/06 , A61P43/00 , C07D305/12 , C07D407/06 , C07D305/08
CPC分类号： C07D407/06 , C07D305/12
摘要： The compounds of the following structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatmet of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
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公开(公告)号：US4983597A
公开(公告)日：1991-01-08
申请号：US401391
申请日：1989-08-31
IPC分类号： A61K31/34 , A61K31/395 , A61K31/397 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/50 , A61P3/06 , C07D205/08 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , C07D205/08 , C07D405/06
摘要： Compounds of formula (I), which are useful as antihypercholesterolemic agents, are disclosed. ##STR1##
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公开(公告)号：US4920106A
公开(公告)日：1990-04-24
申请号：US388716
申请日：1989-08-01
IPC分类号： C07D317/36 , C07F7/08
CPC分类号： C07F7/0812 , C07D317/36
摘要： This invention relates to acetylenic cyclic carbonates that are useful in the treatment of fungal diseases and hypercholesterolemic conditions.
摘要翻译： 本发明涉及可用于治疗真菌疾病和高胆固醇血症的炔属环状碳酸酯。
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公开(公告)号：US4816477A
公开(公告)日：1989-03-28
申请号：US53646
申请日：1987-05-26
IPC分类号： A61K31/337 , A61K31/365 , A61P3/06 , A61P43/00 , C07D305/12 , C07D305/08
CPC分类号： C07D305/12
摘要： The compounds of the following structural formula (I) ##STR1## ar 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
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9.发明授权
公开(公告)号：US4515722A
公开(公告)日：1985-05-07
申请号：US362632
申请日：1982-03-30
IPC分类号： C07C43/192 , C07C43/196 , C07D493/10 , C07F9/117 , C07F9/40 , C07H15/18 , C07F9/10 , A61K31/66 , C07F9/08 , C07F9/113
CPC分类号： C07D493/10 , C07C43/192 , C07C43/196 , C07F9/117 , C07F9/4081 , C07H15/18 , Y02P20/55
摘要： Phosphatidyl inositol analogs are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These phosphatidyl inositol analogs are prepared by condensation of a protected inositol with a substituted phosphonic or phosphorous acid followed by removal of protecting groups.
摘要翻译： 磷脂酰肌醇类似物被发现是有效的磷脂酶C抑制剂，从而有效的抗炎和止痛剂。 这些磷脂酰肌醇类似物通过将保护的肌醇与取代的膦酸或亚磷酸缩合，然后除去保护基来制备。
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10.发明授权Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents 失效用作抗炎/止痛剂的磺酰基或羰基肌醇衍生物
公开(公告)号：US4474806A
公开(公告)日：1984-10-02
申请号：US376364
申请日：1982-05-10
申请人： Thomas R. Beattie , Shu S. Yang
发明人： Thomas R. Beattie , Shu S. Yang
IPC分类号： A61K31/17 , A61K31/325 , C07C271/06 , C07C309/65 , C07C125/065 , C07C127/15
CPC分类号： C07C317/00 , Y02P20/55
摘要： Sulfonyl or carbonyl derivatives of inositols are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These inositol derivatives are prepared by condensation of a protected inositol with a substituted sulfonic or carboxylic acid derivative followed by removal of protecting groups.
摘要翻译： 肌醇的磺酰基或羰基衍生物被发现是有效的磷脂酶C抑制剂，从而有效的抗炎和止痛剂。 这些肌醇衍生物通过保护的肌醇与取代的磺酸或羧酸衍生物的缩合，然后除去保护基来制备。
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