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    High-throughput methods and systems for screening of compounds to treat/prevent kidney disorders
    1.
    发明申请
    High-throughput methods and systems for screening of compounds to treat/prevent kidney disorders 审中-公开
    用于筛选化合物治疗/预防肾脏疾病的高通量方法和系统

    公开(公告)号：US20050233461A1

    公开(公告)日：2005-10-20

    申请号：US10517044

    申请日：2003-06-04

    申请人： Douglas Levinson ,  Kurt Amsler ,  Matthew Peterson

    发明人： Douglas Levinson ,  Kurt Amsler ,  Matthew Peterson

    IPC分类号： G01N25/14 ,  G01N33/15 ,  G01N33/20

    CPC分类号： G01N33/15 ,  G01N25/147

    摘要： The invention concerns arrays, systems and methods for screening compounds, compositions or conditions useful to treat or prevent kidney diseases. These methods are useful to discover, optimize and select compounds, compositions, or conditions that prevent, inhibit, induce, modify, or reverse physical-state transitions, particularly in-vivo physical-state transitions relating to disease causing processes such as development and growth of renal calculi. Such compounds, compositions, or conditions can be exploited to treat, prevent or manage the disease itself, the cause of the disease, or the symptoms of the disease.

    摘要翻译： 本发明涉及筛选用于治疗或预防肾脏疾病的化合物，组合物或病症的阵列，系统和方法。 这些方法可用于发现，优化和选择预防，抑制，诱导，修饰或逆转物理状态转换的化合物，组合物或病症，特别是与疾病引起过程如发育和生长有关的体内物理状态转化 的肾结石。 可以利用这些化合物，组合物或病症来治疗，预防或治疗疾病本身，疾病的病因或疾病的症状。

    Selected phosphoric acid esters as hardeners for epoxy resins
    2.
    发明授权
    Selected phosphoric acid esters as hardeners for epoxy resins 失效
    选择的磷酸酯作为环氧树脂的硬化剂

    公开(公告)号：US4853455A

    公开(公告)日：1989-08-01

    申请号：US191088

    申请日：1988-05-06

    申请人： Wolfgang Schneider ,  Kurt Amsler

    发明人： Wolfgang Schneider ,  Kurt Amsler

    IPC分类号： C08G59/14 ,  C08G59/18 ,  C08G59/40

    CPC分类号： C08G59/4071 ,  C08G59/1488 ,  C08G59/18

    摘要： The present invention relates to hardenable mixtures containing:(i) a polyglycidyl ether or ester based on an aliphatic, cycloaliphatic or aromatic alcohol or a corresponding carboxylic acid and(ii) a hardener obtainable by reaction of:(A) a mixture of 2-4 mol of a monohydric, aliphatic alcohol and 1 mol of phosphorus pentoxide in an inert organic solvent, or of 2 mol of a dialkyl phosphate or of 2 mol of phosphoric acid, if appropriate in combination with 1-2 mol of a monohydric, aliphatic alcohol, with(B) 0.5-1.5 mol of a diglycidyl ether based on a cycloaliphatic or aromatic diol,with the proviso that the said diglycidyl ether used for the preparation of the hardener has an average molecular weight (number-average) of not more than 2,500 and the said hardener is essentially free from 1,2-epoxide groups.The hardenably mixtures are suitable in particular for the production of coatings.

    摘要翻译： 本发明涉及可硬化混合物，其包含：（i）基于脂族，脂环族或芳族醇或相应羧酸的多缩水甘油醚或酯，和（ii）可通过以下反应获得的固化剂：（A）2- 4摩尔一元脂肪醇和1摩尔五氧化二磷在惰性有机溶剂中，或2摩尔磷酸二烷基酯或2摩尔磷酸，如果合适地与1-2摩尔一元脂族 醇，与（B）0.5-1.5mol基于脂环族或芳族二醇的二缩水甘油醚，条件是用于制备固化剂的所述二缩水甘油醚的平均分子量（数均）不超过 超过2500，所述硬化剂基本上不含1,2-环氧基团。 可硬化混合物特别适用于制备涂料。

    Salts of 2-m-propylimidazole
    5.
    发明授权
    Salts of 2-m-propylimidazole 失效
    2-丙基咪唑盐

    公开(公告)号：US4845234A

    公开(公告)日：1989-07-04

    申请号：US176579

    申请日：1988-04-01

    申请人： Wolfgang Schneider ,  Kurt Amsler

    发明人： Wolfgang Schneider ,  Kurt Amsler

    IPC分类号： F16L58/10 ,  B29C63/36 ,  C07D233/58 ,  C08G59/00 ,  C08G59/50 ,  C08G59/56 ,  C08G59/62 ,  C09D163/00 ,  F16L55/165

    CPC分类号： C09D163/00 ,  C08G59/5093 ,  C08G59/56 ,  F16L55/1651

    摘要： A process is described for lining the inner surfaces of pipes or pipe sections using the Insituform method by pressing a tubular flexible laminate made up of an essentially liquid-impermeable membrane and a fibrous layer which has been impregnated with a binder which is not as yet fully cured with the face with the binder against the inner surface of the pipe by means of liquid pressure in such a way that the laminate takes on the shape of the inner surface of the pipe and the binder becomes fully cured in this state, forming a firmly adhering internal lining. The binder used according to the invention in this process contains(a) a curing agent which is a salt of one or more (poly)amines having at least one tertiary nitrogen atom and one or more aromatic polyols or one or more aliphatically substituted phenols, the aliphatic radical having at least 9 carbon atoms, and(b) a liquid epoxy resin or a liquid mixture of epoxy resins and can, if desired, also contain(c) further additives.The process according to the invention is suitable, for example, for lining the inner surfaces or sewers and of gas and water mains.

    摘要翻译： 描述了使用Insituform方法对管或管部分的内表面进行衬垫的方法，该方法是通过压制由基本上不透液膜和纤维层组成的管状柔性层压材料，所述管状柔性层压材料已被不完全地粘合在一起 使用粘合剂的表面通过液体压力固化在管的内表面上，使得层压体呈管状内表面的形状，并且粘合剂在该状态下完全固化，形成牢固 粘贴内衬。 根据本发明在该方法中使用的粘合剂包含（a）固化剂，其为具有至少一个叔氮原子的一种或多种（多）胺和一种或多种芳族多元醇或一种或多种脂族取代的酚的盐， 具有至少9个碳原子的脂族基团，和（b）液体环氧树脂或环氧树脂的液体混合物，如果需要，可以还含有（c）另外的添加剂。 根据本发明的方法适用于例如用于衬里的内表面或下水道以及气体和水源。

    Process for lining the inner surfaces of pipes or pipe sections
    6.
    发明授权
    Process for lining the inner surfaces of pipes or pipe sections 失效
    用于衬管管道或管道部分的内表面的工艺

    公开(公告)号：US4762585A

    公开(公告)日：1988-08-09

    申请号：US881512

    申请日：1986-06-30

    申请人： Wolfgang Schneider ,  Kurt Amsler

    发明人： Wolfgang Schneider ,  Kurt Amsler

    IPC分类号： F16L58/10 ,  B29C63/36 ,  C07D233/58 ,  C08G59/00 ,  C08G59/50 ,  C08G59/56 ,  C08G59/62 ,  C09D163/00 ,  F16L55/165 ,  B32B31/00

    CPC分类号： C09D163/00 ,  C08G59/5093 ,  C08G59/56 ,  F16L55/1651

    摘要： A Process is described for lining the inner surfaces of pipes or pipe sections using the Insituform method by pressing a tubular flexible laminate made up of an essentially liquid-impermeable membrane and a fibrous layer which has been impregnated with a binder which is not as yet fully cured with the face with the binder against the inner surface of the pipe by means of liquid pressure in such a way that the laminate takes on the shape of the inner surface of the pipe and the binder becomes fully cured in the state, forming a firmly adhering internal lining. The binder used according to the invention in this process contains(a) a curing agent which is a salt of one or more (poly)amines having at least one tertiary nitrogen atom and one or more aromtic polyols or one or more aliphatically substituted phenols, the aliphatic radical having at least 9 carbon atoms, and(b) a liquid epoxy resin or a liquid mixture of epoxy resins and can, if desired, also contain(c) further additives.The process according to the invention is suitable, for example, for lining the inner surfaces of sewers and of gas and water mains.

    摘要翻译： 描述了一种使用Insituform方法对管或管部分的内表面进行衬垫的方法，该方法是通过压制由基本上不透液的膜和纤维层构成的管状柔性层压材料，所述纤维层已经浸渍有尚未完全的粘合剂 使用粘合剂的表面通过液体压力固化在管的内表面上，使得层压体呈管状内表面的形状，并且粘结剂在该状态下完全固化，形成牢固 粘贴内衬。 根据本发明在该方法中使用的粘合剂包含（a）固化剂，其为具有至少一个叔氮原子的一种或多种（多）胺和一种或多种芳族多元醇或一种或多种脂族取代的酚的盐， 具有至少9个碳原子的脂族基团，和（b）液体环氧树脂或环氧树脂的液体混合物，如果需要，可以还含有（c）另外的添加剂。 根据本发明的方法适用于例如用于衬里下水道和气体和水源的内表面。