公开(公告)号：US07722810B2

公开(公告)日：2010-05-25

申请号：US11010773

申请日：2004-12-13

申请人： Douglas P. Allen ,  Dominic P. DiNovo ,  Matthew J. Huddleston ,  Kenneth E. Hughes ,  George A. Keller ,  Keith A. Kuisick ,  Rebeccah P. Quam ,  Cecil R. Robinson ,  Jonathan E. Turner ,  Ernest D. VanHoose ,  Thomas J. Ward ,  Warren P. Williamson, IV

发明人： Douglas P. Allen ,  Dominic P. DiNovo ,  Matthew J. Huddleston ,  Kenneth E. Hughes ,  George A. Keller ,  Keith A. Kuisick ,  Rebeccah P. Quam ,  Cecil R. Robinson ,  Jonathan E. Turner ,  Ernest D. VanHoose ,  Thomas J. Ward ,  Warren P. Williamson, IV

IPC分类号： G01N21/00

CPC分类号： G01N1/36 ,  G01N35/00732 ,  G01N2001/366 ,  Y10T436/2525 ,  Y10T436/2575

摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.

摘要翻译： 一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。 该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。 输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。 冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。 安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。 托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。 分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

公开(公告)号：US20110165615A1

公开(公告)日：2011-07-07

申请号：US13047053

申请日：2011-03-14

申请人： Douglas P. Allen ,  Dominic P. DiNovo ,  George A. Keller ,  Rebeccah P. Quam ,  Thomas J. Ward ,  Warren P. Williamson, IV

发明人： Douglas P. Allen ,  Dominic P. DiNovo ,  George A. Keller ,  Rebeccah P. Quam ,  Thomas J. Ward ,  Warren P. Williamson, IV

IPC分类号： G01N1/30 ,  C12M1/34

CPC分类号： G01N1/36 ,  G01N35/00732 ,  G01N2001/366 ,  Y10T436/2525 ,  Y10T436/2575

摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.

摘要翻译： 一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。 该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。 输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。 冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。 安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。 托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。 分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

公开(公告)号：US20100129859A1

公开(公告)日：2010-05-27

申请号：US12696506

申请日：2010-01-29

申请人： Douglas P. Allen ,  Dominic P. DiNovo ,  Matthew J. Huddleston ,  Kenneth E. Hughes ,  George A. Keller ,  Keith A. Kuisick ,  Rebeccah P. Quam ,  Cecil R. Robinson ,  Jonathan E. Turner ,  Ernest D. VanHoose ,  Thomas J. Ward ,  Warren P. Williamson, IV

发明人： Douglas P. Allen ,  Dominic P. DiNovo ,  Matthew J. Huddleston ,  Kenneth E. Hughes ,  George A. Keller ,  Keith A. Kuisick ,  Rebeccah P. Quam ,  Cecil R. Robinson ,  Jonathan E. Turner ,  Ernest D. VanHoose ,  Thomas J. Ward ,  Warren P. Williamson, IV

IPC分类号： G01N1/30 ,  C12M1/34

CPC分类号： G01N1/36 ,  G01N35/00732 ,  G01N2001/366 ,  Y10T436/2525 ,  Y10T436/2575

摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.

摘要翻译： 一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。 该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。 输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。 冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。 安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。 托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。 分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件承载的至少一个组织样本。

公开(公告)号：US08034292B2

公开(公告)日：2011-10-11

申请号：US13047053

申请日：2011-03-14

申请人： Douglas P. Allen ,  Dominic P. DiNovo ,  George A. Keller ,  Rebeccah P. Quam ,  Thomas J. Ward ,  Warren P. Williamson, IV

发明人： Douglas P. Allen ,  Dominic P. DiNovo ,  George A. Keller ,  Rebeccah P. Quam ,  Thomas J. Ward ,  Warren P. Williamson, IV

IPC分类号： G01N21/00

CPC分类号： G01N1/36 ,  G01N35/00732 ,  G01N2001/366 ,  Y10T436/2525 ,  Y10T436/2575

摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.

摘要翻译： 一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。 该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。 输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。 冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。 安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。 托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。 分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。

公开(公告)号：US6162233A

公开(公告)日：2000-12-19

申请号：US369196

申请日：1999-08-06

申请人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

发明人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/115 ,  A61B17/34 ,  A61B19/00 ,  A61F2/24 ,  A61B17/10

CPC分类号： A61B17/0644 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/0684 ,  A61B17/072 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/07214 ,  A61B2017/07242 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395 ,  A61F2/2409 ,  A61F2/2427

摘要： Wire fasteners having legs with lengths that can be one hundred times the width of the fastener are used to secure items, such as prosthesis valves to a patient during minimally invasive surgery. The fasteners are manipulated into position and then are immobilized by the legs thereof for tensioning, cutting and forming in situ. The fasteners are manipulated, tensioned and formed from the leg end of the fasteners. Tools for initially placing the fasteners and for immobilizing, tensioning, cutting and bending the fastener legs are disclosed. Once the fasteners are initially placed, the prosthesis is placed on the long legs of the placed fasteners and is guided into position on the legs. Once the prosthesis is in position, the legs of the fasteners are immobilized, tensioned, cut and bent into staple-like shapes to secure the prosthesis to the patient. A method for carrying out the procedure using the long fastener is also disclosed. Using the teaching of the present disclosure, a surgeon can customize a fastener to the particular surgery or even to the particular portion of surgery being performed during the surgery.

摘要翻译： 具有长度为紧固件宽度的一百倍的腿的电线紧固件用于在微创手术期间将物品（例如假体瓣膜）固定到患者。 紧固件被操纵到位，然后被其腿固定，用于张紧，切割和成形。 紧固件由紧固件的腿端被操纵，张紧和形成。 公开了用于初始放置紧固件并固定，张紧，切割和弯曲紧固件腿的工具。 一旦紧固件被初始放置，假体被放置在所放置的紧固件的长腿上并被引导到腿上的位置。 一旦假体就位，紧固件的腿被固定，张紧，切割并弯曲成钉状形状以将假体固定到患者身上。 还公开了一种使用该长紧固件执行该过程的方法。 使用本公开的教导，外科医生可以定制针对特定手术的紧固件，或甚至可以在手术期间执行手术的特定部分。

公开(公告)号：US07722642B2

公开(公告)日：2010-05-25

申请号：US10786657

申请日：2004-02-25

申请人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

发明人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

IPC分类号： A61B17/08 ,  A61B17/10

CPC分类号： A61F2/2427 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/0684 ,  A61B17/072 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0641 ,  A61B2017/0725 ,  A61B2017/07271 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395 ,  A61F2/2409

摘要： Wire fasteners having legs with lengths that can be one hundred times the width of the fastener are used to secure items, such as prosthesis valves to a patient during minimally invasive surgery. The fasteners are manipulated into position and then are immobilized by means of the legs thereof for tensioning, cutting and forming in situ. The fasteners are manipulated, tensioned and formed from the leg end of the fasteners. Tools for initially placing the fasteners and for immobilizing, tensioning, cutting and bending the fastener legs are disclosed. Once the fasteners are initially placed, the prosthesis is placed on the long legs of the placed fasteners and is guided into position on the legs. Once the prosthesis is in position, the legs of the fasteners are immobilized, tensioned, cut and bent into staple-like shapes to secure the prosthesis to the patient. A method for carrying out the procedure using the long fastener is also disclosed. Using the teaching of the present disclosure, a surgeon can customize a fastener to the particular surgery or even to the particular portion of surgery being performed during the surgery.

摘要翻译： 具有长度为紧固件宽度的一百倍的腿的电线紧固件用于在微创手术期间将物品（例如假体瓣膜）固定到患者。 紧固件被操纵到位，然后通过其腿部固定，用于原位张紧，切割和成形。 紧固件由紧固件的腿端被操纵，张紧和形成。 公开了用于初始放置紧固件并固定，张紧，切割和弯曲紧固件腿的工具。 一旦紧固件被初始放置，假体被放置在所放置的紧固件的长腿上并且被引导到腿上的位置。 一旦假体就位，紧固件的腿被固定，张紧，切割并弯曲成钉状形状以将假体固定到患者身上。 还公开了一种使用该长紧固件执行该过程的方法。 使用本公开的教导，外科医生可以定制针对特定手术的紧固件，或甚至可以在手术期间执行手术的特定部分。

公开(公告)号：US5972004A

公开(公告)日：1999-10-26

申请号：US026671

申请日：1998-02-20

申请人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

发明人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/115 ,  A61B17/34 ,  A61B19/00 ,  A61F2/24

CPC分类号： A61B17/0469 ,  A61B17/0644 ,  A61B17/0684 ,  A61B17/072 ,  A61F2/2409 ,  A61F2/2427 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0641 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395

摘要： Wire fasteners having legs with lengths that can be one hundred times the width of the fastener are used to secure items, such as prosthesis valves to a patient during minimally invasive surgery. The fasteners are manipulated into position and then are immobilized by means of the legs thereof for tensioning, cutting and forming in situ. The fasteners are manipulated, tensioned and formed from the leg end of the fasteners. Tools for initially placing the fasteners and for immobilizing, tensioning, cutting and bending the fastener legs are disclosed. Once the fasteners are initially placed, the prosthesis is placed on the long legs of the placed fasteners and is guided into position on the legs. Once the prosthesis is in position, the legs of the fasteners are immobilized, tensioned, cut and bent into staple-like shapes to secure the prosthesis to the patient. A method for carrying out the procedure using the long fastener is also disclosed. Using the teaching of the present disclosure, a surgeon can customize a fastener to the particular surgery or even to the particular portion of surgery being performed during the surgery.

摘要翻译： 具有长度为紧固件宽度的一百倍的腿的电线紧固件用于在微创手术期间将物品（例如假体瓣膜）固定到患者。 紧固件被操纵到位，然后通过其腿部固定，用于原位张紧，切割和成形。 紧固件由紧固件的腿端被操纵，张紧和形成。 公开了用于初始放置紧固件并固定，张紧，切割和弯曲紧固件腿的工具。 一旦紧固件被初始放置，假体被放置在所放置的紧固件的长腿上并且被引导到腿上的位置。 一旦假体就位，紧固件的腿被固定，张紧，切割并弯曲成钉状形状以将假体固定到患者身上。 还公开了一种使用该长紧固件执行该过程的方法。 使用本公开的教导，外科医生可以定制针对特定手术的紧固件，或甚至可以在手术期间执行手术的特定部分。

公开(公告)号：US6042607A

公开(公告)日：2000-03-28

申请号：US802948

申请日：1997-02-21

申请人： Warren Williamson, IV ,  Paul A. Spence ,  George T. Christakis ,  Thomas J. Ward ,  Dominic P. DiNovo ,  George A. Keller ,  Cecil R. Robinson ,  E. Dale VanHoose

发明人： Warren Williamson, IV ,  Paul A. Spence ,  George T. Christakis ,  Thomas J. Ward ,  Dominic P. DiNovo ,  George A. Keller ,  Cecil R. Robinson ,  E. Dale VanHoose

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/115 ,  A61B17/34 ,  A61B19/00 ,  A61F2/24

CPC分类号： A61B17/072 ,  A61B17/0469 ,  A61B17/0644 ,  A61B17/0684 ,  A61F2/2409 ,  A61F2/2427 ,  A61F2/2496 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/047 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395

摘要： A heart valve can be replaced using minimally invasive methods which include a sutureless sewing cuff that and a fastener delivery tool that holds the cuff against the patient's tissue while delivering fasteners, two at a time to attach the cuff to the tissue from the inside out. The tool stores a plurality of fasteners. Drawstrings are operated from outside the patient's body and cinch the sewing cuff to the valve body. The cuff is releasably mounted on the tool and the tool holds the cuff against tissue and drives the fastener through the cuff and the tissue before folding over the legs of the fastener whereby secure securement between the cuff and the tissue is assured. At least two rows of staggered fasteners are formed whereby fasteners are located continuously throughout the entire circumference of the cuff. A minimally invasive surgical method is disclosed, and a method and tool are disclosed for repairing abdominal aortic aneurysms in a minimally invasive manner.

摘要翻译： 可以使用微创方法来替换心脏瓣膜，所述方法包括无缝线缝合口袋，以及紧固件递送工具，其在递送紧固件的同时将袖带保持在患者组织上，同时两次将袖带从内向外连接到组织。 该工具存储多个紧固件。 束带从患者身体外部进行操作，并将缝合袖带固定在阀体上。 袖带可释放地安装在工具上，并且工具将袖带保持抵靠组织，并且在折叠紧固件的腿部之前通过袖口和组织驱动紧固件，从而确保袖带和组织之间的牢固固定。 形成至少两排交错的紧固件，由此紧固件连续地位于袖带的整个圆周上。 公开了一种微创手术方法，并且公开了一种以微创方式修复腹主动脉瘤的方法和工具。

公开(公告)号：US06406424B1

公开(公告)日：2002-06-18

申请号：US09398535

申请日：1999-09-16

申请人： Warren P. Williamson, IV ,  Paul A. Spence ,  Mark Ortiz ,  George A. Keller ,  Harry Leonard Green, II

发明人： Warren P. Williamson, IV ,  Paul A. Spence ,  Mark Ortiz ,  George A. Keller ,  Harry Leonard Green, II

IPC分类号： A61B132

CPC分类号： A61B17/02 ,  A61B1/32 ,  A61B2017/0243 ,  A61B2017/306

摘要： Devices and methods are disclosed for stabilizing tissue within a patient's body during a surgical operation to provide a relatively motionless surgical field, such as during a coronary artery bypass graft procedure. The devices include tissue stabilizers which engage and provide stabilization to a targeted area of tissue and further have the ability to engage and manipulate some portion of tissue within or adjacent the targeted area to improve the surgical presentation of that portion of tissue. The tissue stabilizer typically has one or more stabilizer feet which have a first foot portion configured to provide stabilization to the targeted tissue and a second foot portion moveable relative to the first foot portion for manipulating a portion of tissue to improve the surgical presentation.

摘要翻译： 公开了用于在外科手术期间稳定患者体内的组织以提供相对不动的外科手术领域的装置和方法，例如在冠状动脉旁路移植手术期间。 所述装置包括组织稳定器，所述组织稳定器与组织的目标区域接合并提供稳定性，并且还具有接合和操纵在目标区域内或附近的组织的一部分的能力，以改善该部分组织的手术呈现。 组织稳定器通常具有一个或多个稳定器脚，其具有被配置为向目标组织提供稳定性的第一脚部和相对于第一脚部移动的第二脚部，用于操纵一部分组织以改善手术呈现。

公开(公告)号：US07326177B2

公开(公告)日：2008-02-05

申请号：US10137643

申请日：2002-04-30

申请人： William P. Williamson, IV ,  Paul A. Spence ,  Mark Ortiz ,  George A. Keller ,  Harry Leonard Green, II

发明人： William P. Williamson, IV ,  Paul A. Spence ,  Mark Ortiz ,  George A. Keller ,  Harry Leonard Green, II

IPC分类号： A61B1/32 ,  A61F2/00

CPC分类号： A61B17/02 ,  A61B1/32 ,  A61B2017/0243 ,  A61B2017/306

摘要： Devices and methods are disclosed for stabilizing tissue within a patient's body during a surgical operation to provide a relatively motionless surgical field, such as during a coronary artery bypass graft procedure. The devices include tissue stabilizers which engage and provide stabilization to a targeted area of tissue and further have the ability to engage and manipulate some portion of tissue within or adjacent the targeted area to improve the surgical presentation of that portion of tissue. The tissue stabilizer typically has one or more stabilizer feet which have a first foot portion configured to provide stabilization to the targeted tissue and a second foot portion moveable relative to the first foot portion for manipulating a portion of tissue to improve the surgical presentation.