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    SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY
    1.
    发明申请
    SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY 有权
    内镜角解决低相干干涉的系统与方法

    公开(公告)号：US20130265582A1

    公开(公告)日：2013-10-10

    申请号：US13868215

    申请日：2013-04-23

    Applicant: DUKE UNIVERSITY

    Inventor： Adam Wax ,  John W. Pyhtila

    IPC: G01J3/45

    CPC classification number: A61B5/0084 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0075 ,  G01B9/02043 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01B9/02091 ,  G01J3/45 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

    Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

    Abstract translation: 傅里叶域a / LCI（faLCI）系统和方法，使用单次扫描能够以快速的速率进行体内数据采集。 通过一次扫描获得角度分辨和深度解析的光谱信息。 由于仅需要一次扫描，参考臂可以相对于样品保持固定。 参考信号和反射的采样信号以相对于样本的多个反射角度相互相关并分散，从而同时并行地表示来自样品上的多个点的反射。 可以通过大约40毫秒量级的一次扫描获得关于样本上多个不同点的每个样本的所有深度的信息。 从空间相互关联的参考信号，也可以使用允许从角度分辨数据获得散射体的尺寸信息的技术来获得结构（尺寸）信息。

    SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY
    2.
    发明申请
    SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY 审中-公开
    内镜角解决低相干干涉的系统与方法

    公开(公告)号：US20150045677A1

    公开(公告)日：2015-02-12

    申请号：US14494080

    申请日：2014-09-23

    Applicant: Duke University

    Inventor： Adam Wax ,  John W. Pyhtila

    IPC: A61B5/00 ,  A61B1/00 ,  G01B9/02

    CPC classification number: A61B5/0084 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0075 ,  G01B9/02043 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01B9/02091 ,  G01J3/45 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

    Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.

    Abstract translation: 评估组织健康的方法包括以下步骤：获得体内组织的选定区域的深度分辨光谱，以及基于散射体的深度分辨结构信息来评估所选区域的健康状况。 获得所选区域的深度分辨光谱包括将样品光束以一定角度朝向选定区域引导，并且接收角度分辨的散射样品光束。 角度分辨的散射采样光束与参考光束交叉相关，以产生关于所选区域的角度分辨的交叉相关信号，其被频谱分散以产生具有深度的角度分辨，频谱分辨的互相关分布 解决有关所选区域的信息。 处理角度分辨的，光谱解析的互相关轮廓以获得关于所选区域中的散射体的深度解析信息。

    Systems and methods for endoscopic angle-resolved low coherence interferometry
    3.
    发明授权
    Systems and methods for endoscopic angle-resolved low coherence interferometry 有权
    内镜角度分辨低相干干涉测量系统和方法

    公开(公告)号：US08860945B2

    公开(公告)日：2014-10-14

    申请号：US13868215

    申请日：2013-04-23

    Applicant: Duke University

    Inventor： Adam Wax ,  John W. Pyhtila

    IPC: G01B9/02 ,  G01J3/45 ,  G01N21/31 ,  A61B5/00 ,  G01N21/47

    CPC classification number: A61B5/0084 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0075 ,  G01B9/02043 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01B9/02091 ,  G01J3/45 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

    Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

    Abstract translation: 傅里叶域a / LCI（faLCI）系统和方法，使用单次扫描能够以快速的速率进行体内数据采集。 通过一次扫描获得角度分辨和深度解析的光谱信息。 由于仅需要一次扫描，参考臂可以相对于样品保持固定。 参考信号和反射的采样信号以相对于样本的多个反射角度相互相关并分散，从而同时并行地表示来自样品上的多个点的反射。 可以通过大约40毫秒量级的一次扫描获得关于样本上多个不同点的每个样本的所有深度的信息。 从空间相互关联的参考信号，也可以使用允许从角度分辨数据获得散射体的尺寸信息的技术来获得结构（尺寸）信息。

    Systems and methods for endoscopic angle-resolved low coherence interferometry
    4.
    发明授权
    Systems and methods for endoscopic angle-resolved low coherence interferometry 有权

    公开(公告)号：US10292595B2

    公开(公告)日：2019-05-21

    申请号：US15634456

    申请日：2017-06-27

    Applicant: Duke University

    Inventor： Adam Wax ,  John W. Pyhtila

    IPC: G01B9/02 ,  G01J3/45 ,  A61B5/00 ,  G01N21/31 ,  G01N21/47 ,  A61B1/00

    Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.

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