公开(公告)号：US11464795B2

公开(公告)日：2022-10-11

申请号：US16630309

申请日：2018-07-12

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  YUNNAN UNIVERSITY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Honglin Li ,  Weilie Xiao ,  Lili Zhu ,  Lina Quan ,  Qiao Li ,  Yanyan Diao ,  Zhenjiang Zhao ,  Hualiang Jiang

IPC分类号： A61K31/704 ,  A61P35/00 ,  A61K31/56

摘要： Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.

公开(公告)号：US10479798B2

公开(公告)日：2019-11-19

申请号：US15523058

申请日：2015-10-30

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Honglin Li ,  Hualiang Jiang ,  Yufang Xu ,  Jia Li ,  Zhenjiang Zhao ,  Jingya Li ,  Hongling Xu ,  Shiliang Li

IPC分类号： C07D311/60 ,  C07D311/92 ,  C07D405/04 ,  C07D493/04 ,  A61K31/352 ,  A61K31/5377 ,  C07D221/10 ,  C07D335/04 ,  C07D417/04

摘要： The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.

公开(公告)号：US09670213B2

公开(公告)日：2017-06-06

申请号：US14400508

申请日：2013-04-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Xiaofeng Liu ,  Wei Zhou ,  Fang Bai ,  Mengzhu Xue ,  Lei Zhang ,  Youli Zhang

IPC分类号： C07D401/12 ,  C07D475/04 ,  C07D487/02 ,  C07D475/00 ,  C07D239/50

CPC分类号： C07D475/00 ,  C07D239/50

摘要： Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.

公开(公告)号：US11590109B2

公开(公告)日：2023-02-28

申请号：US16306465

申请日：2017-06-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES

发明人： Ke Xu ,  Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Lili Zhu ,  Wenlin Song ,  Yi Tong

IPC分类号： A61K31/426 ,  A61P31/12 ,  C07D277/50

摘要： Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:

公开(公告)号：US10919869B2

公开(公告)日：2021-02-16

申请号：US16302564

申请日：2017-05-17

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin Li ,  Yufang Xu ,  Rui Wang ,  Zhenjiang Zhao ,  Wenlin Song ,  Liuxin Xu

IPC分类号： C07D277/50 ,  A61P19/02 ,  A61P37/00 ,  A61P33/00 ,  A61K31/426 ,  A61P35/00 ,  A61P17/06 ,  A61P31/04

摘要： A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.

公开(公告)号：US11306095B2

公开(公告)日：2022-04-19

申请号：US15577518

申请日：2016-05-30

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Wei Zhou ,  Yuqiong Xu ,  Deheng Sun ,  Xia Wang ,  Zhuo Chen

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P35/02 ,  A61K31/519 ,  C07D475/00

摘要： The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.

公开(公告)号：US11534427B2

公开(公告)日：2022-12-27

申请号：US16302574

申请日：2017-05-17

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin Li ,  Zhenjiang Zhao ,  Rui Wang ,  Yufang Xu ,  Wanqi Wang ,  Yingfang Yang

IPC分类号： A61K31/426 ,  A61P1/04

摘要： The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis. The present invention specifically relates to applications of a compound represented by formula I and a pharmaceutical composition containing the compound represented by formula I, in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis:

公开(公告)号：US20150126508A1

公开(公告)日：2015-05-07

申请号：US14400508

申请日：2013-04-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Xiaofeng Liu ,  Wei Zhou ,  Fang Bai ,  Mengzhu Xue ,  Lei Zhang ,  Youli Zhang

IPC分类号： C07D475/00

CPC分类号： C07D475/00 ,  C07D239/50

摘要： Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.

摘要翻译： 提供用作EGFR，BLK和FLT3抑制剂的蝶啶酮衍生物及其应用。 具体地，提供下式I的化合物，含有式I化合物的药物组合物，以及化合物在制备用于治疗由EGFR，BLK或FLT3介导的疾病或抑制EGFR，BLK和FLT3的疾病的药物中的用途。