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    Connectors For Pneumatic Devices In Microfluidic Systems
    4.
    发明申请
    Connectors For Pneumatic Devices In Microfluidic Systems 审中-公开

    公开(公告)号：US20190210017A1

    公开(公告)日：2019-07-11

    申请号：US16351828

    申请日：2019-03-13

    Applicant: EMD Millipore Corporation

    Inventor： Terry Gaige ,  Andrew Zayac ,  Paul Sydlowski ,  Philip Lee

    IPC: B01L3/00 ,  G01N35/00 ,  C12M3/06 ,  C12M1/00

    Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.

    Micro-incubation systems for microfluidic cell culture and methods
    5.
    发明授权
    Micro-incubation systems for microfluidic cell culture and methods 有权

    公开(公告)号：US10190085B2

    公开(公告)日：2019-01-29

    申请号：US15163818

    申请日：2016-05-25

    Applicant: EMD Millipore Corporation

    Inventor： Philip J. Lee ,  Terry Gaige ,  Wei Hsuan (Jessie) Ho

    IPC: C12M3/06 ,  C12M1/00 ,  C12Q1/02 ,  C12M1/34 ,  B01L3/00 ,  B01L7/00 ,  C12M1/107 ,  C12M1/02 ,  C12M1/36 ,  G01N33/50 ,  G01N33/574

    Abstract: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems are disclosed. Various embodiments relate to assays, systems, and/or devices for culturing cells or other biologic material in controlled environments and are applicable to related fields generally using microfluidic systems. Particular embodiments involve configurations that can be used with various standard automated handling systems, with active or passive loading and perfusion of medium and to provide high-throughput multi-assay automated systems for culturing, viewing, and analyzing cell growth, invasion, movement, chemotaxis or other properties. More specifically, specific embodiments relate to heat control systems for microfluidic culture plates and other automated systems for culture plates.

    Connectors for pneumatic devices in microfluidic systems
    7.
    发明授权
    Connectors for pneumatic devices in microfluidic systems 有权

    公开(公告)号：US10737266B2

    公开(公告)日：2020-08-11

    申请号：US16351828

    申请日：2019-03-13

    Applicant: EMD Millipore Corporation

    Inventor： Terry Gaige ,  Andrew Zayac ,  Paul Sydlowski ,  Philip Lee

    IPC: G01N21/00 ,  G01N1/10 ,  B01L3/00 ,  A61J1/06 ,  C23F11/00 ,  A61L2/00 ,  C12M3/06 ,  C12M1/00 ,  G01N35/00

    Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port. A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.

    Connectors for pneumatic devices in microfluidic systems
    9.
    发明授权
    Connectors for pneumatic devices in microfluidic systems 有权

    公开(公告)号：US10272429B2

    公开(公告)日：2019-04-30

    申请号：US15831976

    申请日：2017-12-05

    Applicant: EMD Millipore Corporation

    Inventor： Terry Gaige ,  Andrew Zayac ,  Paul Sydlowski ,  Philip Lee

    IPC: B01L3/00 ,  A61J1/06 ,  B01L99/00 ,  C12M3/06 ,  C12M1/00 ,  G01N35/00

    Abstract: In one embodiment, a removable pneumatic connector, comprises a body having a plurality of bores passing through, each bore surrounded by a sealing member on an inner surface of the body. A plurality of gas lines may be placed within a corresponding bore. A vacuum port is disposed on the inner surface of the body, and an outer seal on the inner surface of the body surrounds the sealing members and the vacuum port.A vacuum line may be placed within the vacuum port, and configured to deliver negative pressure to the vacuum port. A vacuum holding area is created in the volume between the outer seal and each of the sealing members when the inner surface of the body is placed against a substrate. When the vacuum line is activated, a vacuum is created within the vacuum holding area, creating a positive seal between the body and the substrate.

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