公开(公告)号：US11841361B2

公开(公告)日：2023-12-12

申请号：US17406732

申请日：2021-08-19

Applicant: EMULATE, INC.

Inventor： Kyung-Jin Jang ,  Janey Ronxhi ,  Josiah Sliz ,  Sauveur Jeanty ,  Sushma Jadalannagari ,  Ananth Nookala ,  Hyoungshin Park

IPC: G01N33/50 ,  C12N5/071

CPC classification number: G01N33/5088 ,  C12N5/0684 ,  C12N5/0691 ,  C12N5/0697 ,  G01N33/5014 ,  G01N33/5044 ,  G01N33/5064

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.

公开(公告)号：US20240036033A1

公开(公告)日：2024-02-01

申请号：US18474875

申请日：2023-09-26

Applicant: EMULATE, INC.

Inventor： Kyung-Jin Jang ,  Jamey Ronxhi ,  Josiah Sliz ,  Sauveur Jeanty ,  Sushma Jadalannagari ,  Ananth Nookala ,  Hyoungshin Park

IPC: G01N33/50 ,  C12N5/071

CPC classification number: G01N33/5088 ,  C12N5/0684 ,  C12N5/0691 ,  G01N33/5064 ,  G01N33/5014 ,  G01N33/5044 ,  C12N5/0697

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.

公开(公告)号：US11534753B2

公开(公告)日：2022-12-27

申请号：US16352234

申请日：2019-03-13

Applicant: EMULATE, Inc.

Inventor： Ville Kujala ,  Hyoungshin Park ,  Sonalee Barthakur ,  Sauveur Jeanty ,  Brian Zuckerman ,  Josiah Sliz ,  Tanvi Shroff ,  Geraldine A Hamilton ,  Kyung-Jin Jang ,  Ananth Nookala ,  Gang Luo ,  Donald Mckenzie

IPC: B01L3/00 ,  C12M3/06 ,  C12Q1/6809 ,  G01N33/50 ,  C12M1/12

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.

公开(公告)号：US20200269234A1

公开(公告)日：2020-08-27

申请号：US16352234

申请日：2019-03-13

Applicant: EMULATE, Inc.

Inventor： Ville Kujala ,  Hyoungshin Park ,  Sonalee Barthakur ,  Sauveur Jeanty ,  Brian Zuckerman ,  Josiah Sliz ,  Tanvi Shroff ,  Geraldine A. Hamilton ,  Kyung-Jin Jang ,  Ananth Nookala ,  Gang Luo ,  Donald Mckenzie

IPC: B01L3/00 ,  C12M3/06

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.