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公开(公告)号：US12098356B2
公开(公告)日：2024-09-24
申请号：US17953889
申请日：2022-09-27
Applicant: EMULATE, Inc.
Inventor： Christopher David Hinojosa , Josiah Sliz , Iosif Pediaditakis , Sonalee Barthakur
CPC classification number: C12M29/10 , B01L3/502738 , C12M23/16 , C12M29/14 , B01L2300/0861 , B01L2400/0605 , C12M33/00 , G01N1/18
Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.
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公开(公告)号：US20240124822A1
公开(公告)日：2024-04-18
申请号：US17953889
申请日：2022-09-27
Applicant: EMULATE, Inc.
Inventor： Christopher David Hinojosa , Josiah Sliz , Iosif Pediaditakis , Sonalee Barthakur
CPC classification number: C12M29/10 , B01L3/502738 , C12M23/16 , C12M29/14 , B01L2300/0861 , B01L2400/0605 , G01N1/18
Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.
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公开(公告)号：US20240036033A1
公开(公告)日：2024-02-01
申请号：US18474875
申请日：2023-09-26
Applicant: EMULATE, INC.
Inventor： Kyung-Jin Jang , Jamey Ronxhi , Josiah Sliz , Sauveur Jeanty , Sushma Jadalannagari , Ananth Nookala , Hyoungshin Park
CPC classification number: G01N33/5088 , C12N5/0684 , C12N5/0691 , G01N33/5064 , G01N33/5014 , G01N33/5044 , C12N5/0697
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US11697792B2
公开(公告)日：2023-07-11
申请号：US16712439
申请日：2019-12-12
Applicant: EMULATE, INC.
Inventor： Christopher David Hinojosa , Josiah Sliz , Iosif Pediaditakis , Sonalee Barthakur
CPC classification number: C12M29/10 , B01L3/502738 , C12M23/16 , C12M29/14 , B01L2300/0861 , B01L2400/0605 , C12M33/00 , G01N1/18
Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.
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公开(公告)号：US11534753B2
公开(公告)日：2022-12-27
申请号：US16352234
申请日：2019-03-13
Applicant: EMULATE, Inc.
Inventor： Ville Kujala , Hyoungshin Park , Sonalee Barthakur , Sauveur Jeanty , Brian Zuckerman , Josiah Sliz , Tanvi Shroff , Geraldine A Hamilton , Kyung-Jin Jang , Ananth Nookala , Gang Luo , Donald Mckenzie
IPC: B01L3/00 , C12M3/06 , C12Q1/6809 , G01N33/50 , C12M1/12
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.
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Patent Agency Ranking
公开(公告)号：US20200269234A1
公开(公告)日：2020-08-27
申请号：US16352234
申请日：2019-03-13
Applicant: EMULATE, Inc.
Inventor： Ville Kujala , Hyoungshin Park , Sonalee Barthakur , Sauveur Jeanty , Brian Zuckerman , Josiah Sliz , Tanvi Shroff , Geraldine A. Hamilton , Kyung-Jin Jang , Ananth Nookala , Gang Luo , Donald Mckenzie
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.
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公开(公告)号：US12019083B2
公开(公告)日：2024-06-25
申请号：US17834165
申请日：2022-06-07
Applicant: EMULATE, Inc.
Inventor： Josiah Sliz , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
CPC classification number: G01N35/00584 , B01L3/502761 , C12Q3/00 , G01N15/06 , G01N33/5008 , B01L3/502707 , B01L2200/0647 , B01L2200/148 , B01L2300/0681 , B01L2300/069 , B01L2300/10 , B01L2400/0406 , G01N2035/00544 , G01N2035/0097
Abstract: The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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公开(公告)号：US11841361B2
公开(公告)日：2023-12-12
申请号：US17406732
申请日：2021-08-19
Applicant: EMULATE, INC.
Inventor： Kyung-Jin Jang , Janey Ronxhi , Josiah Sliz , Sauveur Jeanty , Sushma Jadalannagari , Ananth Nookala , Hyoungshin Park
CPC classification number: G01N33/5088 , C12N5/0684 , C12N5/0691 , C12N5/0697 , G01N33/5014 , G01N33/5044 , G01N33/5064
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US20220334139A1
公开(公告)日：2022-10-20
申请号：US17834165
申请日：2022-06-07
Applicant: EMULATE, Inc.
Inventor： Josiah Sliz , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
Abstract: The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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公开(公告)号：US12298320B2
公开(公告)日：2025-05-13
申请号：US17538518
申请日：2021-11-30
Applicant: EMULATE, Inc.
Inventor： Josiah Sliz , Daniel Levner , Brian Zuckerman , Norman Wen , Jonathan Rubins , Tanvi Shroff , Christopher David Hinojosa , Grace Ahn , Victor Antontsev , Jefferson Puerta , David Conegliano , S. Jordan Kerns
Abstract: The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.
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