公开(公告)号：US20240124822A1

公开(公告)日：2024-04-18

申请号：US17953889

申请日：2022-09-27

Applicant: EMULATE, Inc.

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Iosif Pediaditakis ,  Sonalee Barthakur

IPC: C12M1/00 ,  B01L3/00 ,  C12M3/06

CPC classification number: C12M29/10 ,  B01L3/502738 ,  C12M23/16 ,  C12M29/14 ,  B01L2300/0861 ,  B01L2400/0605 ,  G01N1/18

Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.

公开(公告)号：US20200181555A1

公开(公告)日：2020-06-11

申请号：US16712439

申请日：2019-12-12

Applicant: EMULATE, INC.

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  losif Pediaditakis ,  Sonalee Barthakur

IPC: C12M1/00 ,  C12M3/06 ,  B01L3/00

Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.

公开(公告)号：US12098356B2

公开(公告)日：2024-09-24

申请号：US17953889

申请日：2022-09-27

Applicant: EMULATE, Inc.

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Iosif Pediaditakis ,  Sonalee Barthakur

IPC: C12M1/00 ,  B01L3/00 ,  C12M3/06 ,  C12M1/26 ,  G01N1/18

CPC classification number: C12M29/10 ,  B01L3/502738 ,  C12M23/16 ,  C12M29/14 ,  B01L2300/0861 ,  B01L2400/0605 ,  C12M33/00 ,  G01N1/18

Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.

公开(公告)号：US11788044B2

公开(公告)日：2023-10-17

申请号：US16820530

申请日：2020-03-16

Applicant: EMULATE, INC.

Inventor： Antonio Varone ,  Magdalena Kasendra ,  Carolina Lucchesi ,  S. Jordan Kerns ,  Riccardo Barrile ,  Sonalee Barthakur

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/12 ,  C12N5/071 ,  G01N33/50 ,  C12M1/00

CPC classification number: C12M23/16 ,  B01L3/502715 ,  B01L3/502761 ,  C12M23/26 ,  C12M25/02 ,  C12N5/069 ,  G01N33/5047 ,  G01N33/5064 ,  B01L2200/16 ,  B01L2300/123 ,  B01L2300/16 ,  C12N2500/00 ,  C12N2501/052 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/25

Abstract: The present invention contemplates compositions, devices and methods of simulating biological fluids in a fluidic device, including but not limited to a microfluidic chip. In one embodiment, fluid comprising a colloid under flow in a microfluidic chip has a fluid density or viscosity similar to a bodily fluid, e.g. blood, lymph, lung fluid, or the like. In one embodiment, a fluid is provided as a Theologically biomimetic blood surrogate or substitute for simulating physiological shear stress and cell dynamics in fluidic device, including but not limited to immune cells.

公开(公告)号：US20200332240A1

公开(公告)日：2020-10-22

申请号：US16820530

申请日：2020-03-16

Applicant: EMULATE, INC.

Inventor： Antonio Varone ,  Magdalena Kasendra ,  Carolina Lucchesi ,  S. Jordan Kerns ,  Riccardo Barrile ,  Sonalee Barthakur

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12N5/071 ,  G01N33/50

Abstract: The present invention contemplates compositions, devices and methods of simulating biological fluids in a fluidic device, including but not limited to a microfluidic chip. In one embodiment, fluid comprising a colloid under flow in a microfluidic chip has a fluid density or viscosity similar to a bodily fluid, e.g. blood, lymph, lung fluid, or the like. In one embodiment, a fluid is provided as a Theologically biomimetic blood surrogate or substitute for simulating physiological shear stress and cell dynamics in fluidic device, including but not limited to immune cells.

公开(公告)号：US20240076625A1

公开(公告)日：2024-03-07

申请号：US18243242

申请日：2023-09-07

Applicant: EMULATE, INC.

Inventor： Antonio Varone ,  Magdalena Kasendra ,  Carolina Lucchesi ,  S. Jordan Kerns ,  Riccardo Barrile ,  Sonalee Barthakur

IPC: C12N5/071 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M3/06 ,  G01N1/30 ,  G01N33/50

CPC classification number: C12N5/0679 ,  B01L3/502715 ,  B01L3/502761 ,  C12M23/16 ,  C12M23/26 ,  C12M25/02 ,  C12N5/069 ,  G01N1/30 ,  G01N33/5047 ,  G01N33/5064 ,  B01L2200/16 ,  B01L2300/123 ,  B01L2300/16 ,  C12N2500/00 ,  C12N2501/052 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/25

Abstract: The present invention contemplates compositions, devices and methods of simulating biological fluids in a fluidic device, including but not limited to a microfluidic chip. In one embodiment, fluid comprising a colloid under flow in a microfluidic chip has a fluid density or viscosity similar to a bodily fluid, e.g. blood, lymph, lung fluid, or the like. In one embodiment, a fluid is provided as a rheologically biomimetic blood surrogate or substitute for simulating physiological shear stress and cell dynamics in fluidic device, including but not limited to immune cells.

公开(公告)号：US11697792B2

公开(公告)日：2023-07-11

申请号：US16712439

申请日：2019-12-12

Applicant: EMULATE, INC.

Inventor： Christopher David Hinojosa ,  Josiah Sliz ,  Iosif Pediaditakis ,  Sonalee Barthakur

IPC: C12M1/00 ,  B01L3/00 ,  C12M3/06 ,  G01N1/18 ,  C12M1/26

CPC classification number: C12M29/10 ,  B01L3/502738 ,  C12M23/16 ,  C12M29/14 ,  B01L2300/0861 ,  B01L2400/0605 ,  C12M33/00 ,  G01N1/18

Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.

公开(公告)号：US11534753B2

公开(公告)日：2022-12-27

申请号：US16352234

申请日：2019-03-13

Applicant: EMULATE, Inc.

Inventor： Ville Kujala ,  Hyoungshin Park ,  Sonalee Barthakur ,  Sauveur Jeanty ,  Brian Zuckerman ,  Josiah Sliz ,  Tanvi Shroff ,  Geraldine A Hamilton ,  Kyung-Jin Jang ,  Ananth Nookala ,  Gang Luo ,  Donald Mckenzie

IPC: B01L3/00 ,  C12M3/06 ,  C12Q1/6809 ,  G01N33/50 ,  C12M1/12

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.

公开(公告)号：US20200269234A1

公开(公告)日：2020-08-27

申请号：US16352234

申请日：2019-03-13

Applicant: EMULATE, Inc.

Inventor： Ville Kujala ,  Hyoungshin Park ,  Sonalee Barthakur ,  Sauveur Jeanty ,  Brian Zuckerman ,  Josiah Sliz ,  Tanvi Shroff ,  Geraldine A. Hamilton ,  Kyung-Jin Jang ,  Ananth Nookala ,  Gang Luo ,  Donald Mckenzie

IPC: B01L3/00 ,  C12M3/06

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.