公开(公告)号：US11534753B2

公开(公告)日：2022-12-27

申请号：US16352234

申请日：2019-03-13

Applicant: EMULATE, Inc.

Inventor： Ville Kujala ,  Hyoungshin Park ,  Sonalee Barthakur ,  Sauveur Jeanty ,  Brian Zuckerman ,  Josiah Sliz ,  Tanvi Shroff ,  Geraldine A Hamilton ,  Kyung-Jin Jang ,  Ananth Nookala ,  Gang Luo ,  Donald Mckenzie

IPC: B01L3/00 ,  C12M3/06 ,  C12Q1/6809 ,  G01N33/50 ,  C12M1/12

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.

公开(公告)号：US11371000B2

公开(公告)日：2022-06-28

申请号：US15474214

申请日：2017-03-30

Applicant: EMULATE, INC.

Inventor： Geraldine A Hamilton ,  Norman Wen ,  Catherine Karalis ,  Antonio Varone ,  Daniel Levner ,  Riccardo Barrile

IPC: G01N33/50 ,  C12M3/06 ,  C12M1/12 ,  C12N5/09

Abstract: The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.

公开(公告)号：US11725190B2

公开(公告)日：2023-08-15

申请号：US16454753

申请日：2019-06-27

Applicant: EMULATE, INC.

Inventor： Kyung-Jin Jang ,  Hyoungshin Park ,  Sauveur Jeanty ,  Janey Ronxhi ,  Sushma Jadalannagari ,  Geraldine A Hamilton ,  Catherine Karalis

IPC: C12N5/071 ,  B01L3/00 ,  C12M3/06 ,  C12M1/12 ,  G01N33/50 ,  C12Q1/32

CPC classification number: C12N5/0697 ,  B01L3/502715 ,  C12M23/16 ,  C12M25/02 ,  C12N5/0684 ,  C12N5/0691 ,  C12Q1/32 ,  G01N33/5005 ,  G01N33/5014 ,  G01N33/5082 ,  B01L2200/0652 ,  B01L2200/10

Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.